Effect of <i>Libidibia ferrea</i> bark and seed in maternal reproductive and biochemical outcomes and fetal anomaly in rats

Pickler, Thaisa B.; Lopes, Karina P.; Magalhães, Stefani Alves; Krueger, Clarissa M. A.; Martins, Maria; Filho, Valdir Cechinel; Jozala, Ângela Faustino; Grotto, Denise; Gerenutti, Marli

doi:10.1002/bdr2.1520

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…ex Tul.) L. P. Queiroz Bark Phenolic compounds [39,40], tannin, flavonoid, and coumarin [40], gallic acid (phenolic acid), quinic acid (phenolic acid), kaempferol (flavonoid) [41,42], ellagic acid (phenolic acid) [43], tannins [44], catequin (flavonoid) [41], and epicatechin (flavonoid) [45] Branch Phenolic compounds, flavonoids, triterpenes, and saponins [46] Fruits Phenolic compounds [42,[46][47][48][49][50][51], flavonoids, triterpenes, saponins [46], tannins, catechin (tannin), epicatechin (tannin) [42,44,45,52], galloylquinic acid (tannin), galloyl-HHDP-hex (tannin), brevifolin carboxylic acid (tannin), valoneic acid dilactone (tannin), ellagic acid derivative (ellagic acid hex-) (phenolic acid), and dihydroisovaltrate [49], ellagic acid (phenolic acid), gallic acid (phenolic acid) [47,49,[53][54][55][56] Leaves Phenolic compounds [46,57], flavonoids, terpenes, saponins [46,58], alkaloids, cinnamic derivatives, heptacosane (alkane) [58], tannins [57,58], quercetin (flavonoid) [59], ellagic acid (phenolic acid), gallic acid (phenolic acid) [51,60] Seeds Ellagic acid (phenolic acid) [43] Dioclea grandiflora Mart. ex Benth…”

Section: Main Chemical Classes/bioactive Compoundsmentioning

confidence: 99%

Culture matters: A systematic review of antioxidant potential of tree legumes in the semiarid region of Brazil and local processing techniques as a driver of bioaccessibility

et al. 2022

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Ethnobotanical studies report that human populations from the Brazilian Caatinga biome use tree legumes (Fabaceae) with medicinal and food purposes. Our study provides a systematic review of the available published information concerning the antioxidant potential of Hymenaea courbaril L. (jatobá), Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz (jucá), and Dioclea grandiflora Mart. Ex Benth. (mucunã). Furthermore, in this paper, we infer the possible effects of local processing techniques applied to these plants on their antioxidant potential. In order to achieve these goals, we reviewed 52 articles, including studies from ethnobiology (n = 17), chemistry (n = 32), and food studies testing antioxidant activity (n = 17), excluding 14 repetitions. We found that these legume species can inhibit the formation of free radicals and this potential action varies among different parts of the plant. Probably, the presence of phenolic compounds such as phenolic acids and flavonoids, which are not uniformly distributed in the plants, explain their antioxidant activity. Local processing techniques (i.e., roasting, milling) affect the bioaccessibility of antioxidant components of tree legumes, inducing both positive and negative effects. However, studies about the antioxidant potential did not consider local processing techniques in their analyses. Our study highlights that culture is a fundamental driver of nutritional and pharmacological outcomes related to edible resources since it determines which parts of the plant people consume and how they prepare them. Hence, ignoring cultural variables in the analysis of antioxidant activity will produce inaccurate or wrong scientific conclusions.

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Section: Main Chemical Classes/bioactive Compoundsmentioning

confidence: 99%

Culture matters: A systematic review of antioxidant potential of tree legumes in the semiarid region of Brazil and local processing techniques as a driver of bioaccessibility

et al. 2022

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“…Pickler et al [38] studied a hydroalcoholic extract of bark and seed of L. ferrea that had a phytochemical marker of ellagic acid, and at a dose of 1 g/kg orally, concluded that extracts of L. ferrea do not exhibit safety levels compatible with being used in the gestational period.…”

Section: Discussionmentioning

confidence: 99%

Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

et al. 2019

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The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart; however, it is perceived to be related to the concentrations used.

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“…Alguns autores verificaram a toxicidade da planta por meio do uso de extratos alcoólicos em suas pesquisas. Nesses estudos, utilizaram as vagens, casca do caule e sementes (Ferreira et al, 2019;Pickler et al, 2019). Não foram encontrados na literatura, estudos que verificaram toxicidade desta planta por meio do emprego do chá da LF.…”

Section: Composição Químicaunclassified

“…Dentre os compostos fenólicos da LF foram elucidados por Venâncio et al (2021) a presença de ácido gálico, ácido ferúlico, ácido seríngico e ácido clorogênico. A LF apresenta em sua composição fitoquímica os flavónoides, saponinas, taninos, cumarinas, esteróis e compostos fenólicos (Lima et al, 2012) conforme evidenciado também por Pickler et al (2019) no qual foi demonstrado que as sementes dessa planta possuem quantidade de ácido elágico em até 3 vezes mais do que em suas cascas.…”

Section: Determinação De Compostos Fenólicos Flavonóides E Antioxidantesunclassified

Caracterização química do chá e extrato metanólico de vagens com sementes de Libidibia ferrea (Jucá)

Fagiani

Estopa

Silva

et al. 2022

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O Brasil possui abundância em plantas que podem ser utilizadas para fins terapêuticos, dentre elas, o Jucá que possui propriedades antiinflamatórias, antidiarreicas e cicatrizante. Objetivou-se avaliar as características químicas de vagens e sementes do Jucá. Foram preparados o chá e extrato metanólico para determinar o teor de nutrientes do fruto bem como verificou-se a presença de antioxidantes, compostos fenólicos e flavonoides. O Jucá possui Boro (2,57 ± 0,15), Cobre (0,57 ± 0,16), Ferro (11,87 ± 2,14), Manganês (4,93 ± 0,45), Zinco (2,03 ± 0,07), Nitrogênio Total (1,03 ± 0,00), Fósforo (0,12 ± 0,01), Potássio (1,10 ± 0,14), Cálcio (0,22 ± 0,03), Magnésio (0,07 ± 0,01) e Enxofre (0,09 ± 0,01). Na avaliação da composição centesimal verificou-se também a matéria seca (88,57 ± 0,69), extrato etéreo (0,24 ± 0,01), matéria mineral (3,17 ± 0,06), proteína bruta (7,31 ± 0,21), fibra bruta (15,25 ± 0,4), cinzas (24,6 ± 3,18) e composição energética total (92,38 ± 0,87 Kcal/g). O Jucá contém compostos fenólicos no chá (12,22 ± 1,04) e no extrato (142,74 ± 16,59), flavonoides no chá (4,63 ± 0,76) e no extrato (33,89 ± 4,63) e antioxidantes no chá (48,29 ± 5,5) e no extrato (520,87 ± 57,52). O Jucá possui elevado teor de proteina, minerais e de fibras. Houve maior concentração de compostos fenólicos, flavonoides e antioxidantes no extrato metanólico, porém, é por meio do consumo do chá das partes da planta que a população faz o uso do Jucá.

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Effect of Libidibia ferrea bark and seed in maternal reproductive and biochemical outcomes and fetal anomaly in rats

Cited by 6 publications

References 26 publications

Culture matters: A systematic review of antioxidant potential of tree legumes in the semiarid region of Brazil and local processing techniques as a driver of bioaccessibility

Culture matters: A systematic review of antioxidant potential of tree legumes in the semiarid region of Brazil and local processing techniques as a driver of bioaccessibility

Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

Caracterização química do chá e extrato metanólico de vagens com sementes de Libidibia ferrea (Jucá)

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