Effect of <i>Medicago sativa</i> compared To 17β-oestradiol on osteoporosis in ovariectomized mice

Jdidi, Hajer; Koubaa, Fatma Ghorbel; Aoiadni, Nissaf; Elleuch, Aïda; Makni‐Ayadi, Fatma; Feki, Abdelfattah El

doi:10.1080/13813455.2020.1741644

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Based on a literature search, we excluded ingredients that had been reported as follows: bone loss treatment‐related drugs (Oroxylin A, 34 Nomilin, 35 Phenylalanine, 36 Prunetin, 37 Medicagol 38 ); flavonoid and isoflavone‐related substances (Cosmosiin, 39 7‐methoxy‐8‐hydroxy‐4‐phenylcoumarin, 40 Epimedoside A 41 ). Subsequently, traditional Chinese medicines that had been reported to be therapeutically effective or with larger toxic side effects were excluded.…”

Section: Resultsmentioning

confidence: 99%

Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β‐catenin signaling pathways

Lu,

Zeng,

et al. 2023

Anim Models and Exp Med

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BackgroundOsteoporosis is a chronic bone disease characterized by bone loss and decreased bone strength. However, current anti‐resorptive drugs carry a risk of various complications. The deep learning‐based efficacy prediction system (DLEPS) is a forecasting tool that can effectively compete in drug screening and prediction based on gene expression changes. This study aimed to explore the protective effect and potential mechanisms of cinobufotalin (CB), a traditional Chinese medicine (TCM), on bone loss.MethodsDLEPS was employed for screening anti‐osteoporotic agents according to gene profile changes in primary osteoporosis. Micro‐CT, histological and morphological analysis were applied for the bone protective detection of CB, and the osteogenic differentiation/function in human bone marrow mesenchymal stem cells (hBMMSCs) were also investigated. The underlying mechanism was verified using qRT‐PCR, Western blot (WB), immunofluorescence (IF), etc.ResultsA safe concentration (0.25 mg/kg in vivo, 0.05 μM in vitro) of CB could effectively preserve bone mass in estrogen deficiency‐induced bone loss and promote osteogenic differentiation/function of hBMMSCs. Both BMPs/SMAD and Wnt/β‐catenin signaling pathways participated in CB‐induced osteogenic differentiation, further regulating the expression of osteogenesis‐associated factors, and ultimately promoting osteogenesis.ConclusionOur study demonstrated that CB could significantly reverse estrogen deficiency‐induced bone loss, further promoting osteogenic differentiation/function of hBMMSCs, with BMPs/SMAD and Wnt/β‐catenin signaling pathways involved.

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Section: Resultsmentioning

confidence: 99%

Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β‐catenin signaling pathways

Lu,

Zeng,

et al. 2023

Anim Models and Exp Med

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“…For instance, in an ovariectomized rat model, phytoestrogens from Glycine max resulted in improved memory performance, which may be attributed to increased bdnf and synaptic protein gene expression [395]. In other ovariectomized rodent models Pueraria lobata extract promoted oestrogenic activity, by upregulating expression of oestrogen Tyler and Tyler Natural Products and Bioprospecting (2022) 12:34 receptor α (ER-α) [396] and Medicago sativa prevented bone loss induced by oestrogen deficiency [397]. Many of these plant species also demonstrate other bioactivities of AD therapeutic potential.…”

Section: The Oestrogen Hypothesismentioning

confidence: 99%

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Tyler

2022

Nat. Prod. Bioprospect.

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Alzheimer’s disease (AD) is progressive and ultimately fatal, with current drugs failing to reverse and cure it. This study aimed to find plant species which may provide therapeutic bioactivities targeted to causal agents proposed to be driving AD. A novel toolkit methodology was employed, whereby clinical symptoms were translated into categories recognized in ethnomedicine. These categories were applied to find plant species with therapeutic effects, mined from ethnomedical surveys. Survey locations were mapped to assess how this data is at risk. Bioactivities were found of therapeutic relevance to 15 hypothesised causal bases for AD. 107 species with an ethnological report of memory improvement demonstrated therapeutic activity for all these 15 causal bases. The majority of the surveys were found to reside within biodiversity hotspots (centres of high biodiversity under threat), with loss of traditional knowledge the most common threat. Our findings suggest that the documented plants provide a large resource of AD therapeutic potential. In demonstrating bioactivities targeted to these causal bases, such plants may have the capacity to reduce or reverse AD, with promise as drug leads to target multiple AD hallmarks. However, there is a need to preserve ethnomedical knowledge, and the habitats on which this knowledge depends. Graphical Abstract

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“…This article explained that increasing bone matrix density occurs because there is a growth of the inorganic matrix, which is an indicator of higher bone replacement. Accordingly, the phytoestrogen content from M. sativa leaves may lower oxidation lipid and protein biomarkers due to high levels of oxidant production that disturb the balance of normal redox and shift the cells into oxidative stress condition (Jdidi et al, 2020).…”

Section: Activities Of Bone Formation From Plants C Cainito E Guineen...mentioning

confidence: 99%

Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L.

Ma’arif

Suryanto

Muslikh

et al. 2022

J.Pharm.Sci.Community

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Phytoestrogens are compounds from plants that have a structure and function similar to estrogen (17β-estradiol). Phytoestrogens can be found in Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L. This systematic review aimed to prove that all of these five plants have phytoestrogens which were observed with several instruments, and to assess activities and bone forming mechanisms from these five plants in the female mice (Mus musculus) and female rats (Rattus norvegicus). This systematic review was done by identifying articles in several databases (Google Scholar, PubMed, and Science Direct). The process of selecting the articles used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to create a flowchart with inclusion and exclusion study criteria. Meta-synthesis was done to analyze, identify, and interpret all of the data in the articles systematically. 31 articles in total were obtained from the selection process, with 27 articles containing a discussion about chemical compound content and 4 articles describing research results for in vivo testing of the plants that were reviewed. The results showed that these five plants have phytoestrogens and by in vivo testing have the activity in increasing trabecular bone density in the experimental animals.

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Effect of Medicago sativa compared To 17β-oestradiol on osteoporosis in ovariectomized mice

Cited by 5 publications

References 39 publications

Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β‐catenin signaling pathways

Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β‐catenin signaling pathways

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L.

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