Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L.

Ma’arif, Burhan; Suryanto, Suryanto; Muslikh, Faisal Akhmal; Suryadinata, Arif; Fauziyah, Begum

doi:10.24071/jpsc.003166

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Penelitian terbaru yang dilakukan oleh Purwitasari dkk., (2023) menjelaskan bahwa senyawa flavonoid menunjukkan aktivitas penghambatan yang baik terhadap protein spike SARS-COV-2 [19]. Diantara senyawa flavonoid yang terkenal memiliki berbagai manfaat farmakologi seperti antiinflamasi, antiosteoporosis, neurodegeneratif adalah Genistein, Daidzein, Glycitein, Formonoetin, dan Biochanin A [20,21]. Sehingga, penelitian ini bertujuan untuk mengidentifikasi 5 senyawa golongan flavonoid yang sudah terkenal memiliki berbagai manfaat farmakologi dalam menghambat aktivitas RdRP SARS-CoV-2.…”

Section: Pendahuluanunclassified

Studi In Silico Senyawa Flavonoid dalam Mengambat RNA-dependent RNA polymerase (RdRp) sebagai Antivirus COVID-19

Muslikh¹,

Pratama

Ma’arif

et al. 2023

J. Islamic Pharm.

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Pada akhir tahun 2019, muncul coronavirus disease 2019 (COVID-19) yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yang menjadi ancaman serius bagi kesehatan masyarakat global sampai saat ini. Seiring berjalannya waktu, pengembangan drug repurposing telah menjadi metode yang efektif dalam penemuan obat baru. Flavonoid merupakan golongan senyawa yang telah dikenal memiliki aktivitas antivirus. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengidentifikasi lima senyawa flavonoid (Genistein, Daidzein, Glycitein, Formonoetin, dan Biochanin A) yang sudah dikenal memiliki berbagai manfaat farmakologi dalam menghambat aktivitas RdRp SARS-CoV-2. Untuk melakukan analisis, metode molecular docking digunakan dengan menggunakan software AutoDockTools 1.5.6. Prediksi sifat farmakokinetik dan farmakodinamik dilakukan dengan menggunakan SwissADME, sedangkan untuk mengevaluasi toksisitas, digunakan ProTox II. Hasil molecular docking menunjukkan bahwa kelima senyawa flavonoid memiliki hasil yang lebih baik dibandingkan dengan senyawa kontrol positif remdesivir. Selain itu, hasil prediksi sifat farmakokinetik, farmakodinamik, dan toksisitas menunjukkan bahwa Biochanin A, Glycitein, Genistein, dan Formonoetin memiliki potensi terbaik untuk dikembangkan sebagai obat antivirus COVID-19 dengan kemampuan mengikat reseptor RdRp dengan PDB id. 6M71.

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Section: Pendahuluanunclassified

Studi In Silico Senyawa Flavonoid dalam Mengambat RNA-dependent RNA polymerase (RdRp) sebagai Antivirus COVID-19

Muslikh¹,

Pratama

Ma’arif

et al. 2023

J. Islamic Pharm.

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Runt-Related Transcription Factor 2 (Runx2) Measurement in Phytoestrogen-Induced Bone: A Comparison of Western Blot and Immunohistochemistry Methods

Ma’arif

Sholihah

Mahardiani

et al. 2022

Biomed. Pharmacol. J.

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Estrogen deficiency can contribute to osteoporosis in postmenopausal women. Phytoestrogens are becoming more widely recognized as potential estrogen replacement therapy. The administration of phytoestrogens can cause bone formation, which is marked by an increase in Runx2 expression in osteoblast cells and can be seen using western blot and immunohistochemistry approaches. This review aimed to compare the detection methods of Runx2 in phytoestrogen-induced bone tissue using western blots and immunohistochemistry. Selectivity, sensitivity, processing time, and cost-effectiveness were the parameters that were compared. This review was done by identifying articles in several databases (Google Scholar, PubMed, and Science Direct). The process of selecting the articles used the PRISMA guidelines to create a flowchart with inclusion and exclusion study criteria. Meta-synthesis was done to analyze, identify, and interpret all of the data in the articles systematically. 70 articles in total were obtained from the selection process, with 21 articles being relevant to the topic. The result shows that the selectivity and sensitivity of western blot for detecting Runx2 on tissue were 93.5–100%, respectively, whereas immunohistochemistry selectivity and sensitivity were 45–99.5%, respectively. Compared to immunohistochemistry, western blot can save up to 57.26%. Immunohistochemistry takes 46 hours to process, while Western blot takes 25 hours and 20 minutes. In comparison to immunohistochemistry, the western blot is more selective, sensitive, rapid and affordable for detecting Runx2 in bone tissue.

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In Silico Molecular Docking and ADMET Analysis for Drug Development of Phytoestrogens Compound with Its Evaluation of Neurodegenerative Diseases

et al. 2022

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Neurodegenerative disease is one of the problems faced by postmenopausal women due to estrogen deficiency. Phytoestrogen compounds can be used as an alternative treatment for diseases caused by estrogen deficiency by binding to their receptors through the estrogen receptor (ER) dependent pathway. With in silico studies, this study aims to predict how phytoestrogen compounds will stop neurons from dying by using the dependent ER pathway. Genistein, daidzein, glycitein, formononetin, biochanin A, equol, pinoresinol, 4-methoxypinoresinol, eudesmin, α-amyrin, and β-amyrin compounds were prepared with ChemDraw Ultra 12.0. Then their pharmacokinetic and pharmacodynamic properties were examined using SwissADME. Geometry optimization of the compound was performed using Avogadro 1.0.1, and molecular docking of the compound to the ERα (1A52) and ERβ (5TOA) receptors was performed using AutoDock vina (PyRx 0.8). The interaction visualization stage was carried out with Biovia Discover Studio 2021, while the toxicity values of the compounds were analyzed using pkCSM and ProTox II. The results showed that the equol compound met the pharmacokinetic, pharmacodynamic, toxicity criteria, and had similarities with the native ligand 17β-estradiol. Equol compound inhibits neurodegeneration via an ER-dependent pathway by binding to ERα (1A52) and ERβ (5TOA) receptors.

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Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L.

Cited by 3 publications

References 16 publications

Studi In Silico Senyawa Flavonoid dalam Mengambat RNA-dependent RNA polymerase (RdRp) sebagai Antivirus COVID-19

Studi In Silico Senyawa Flavonoid dalam Mengambat RNA-dependent RNA polymerase (RdRp) sebagai Antivirus COVID-19

Runt-Related Transcription Factor 2 (Runx2) Measurement in Phytoestrogen-Induced Bone: A Comparison of Western Blot and Immunohistochemistry Methods

In Silico Molecular Docking and ADMET Analysis for Drug Development of Phytoestrogens Compound with Its Evaluation of Neurodegenerative Diseases

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