Effect of <i>Pistacia palaestina</i> Boiss. Essential Oil on Colorectal Cancer Cells: Inhibition of Proliferation and Migration

Awwad, Oriana; Alabbassi, Reem; Abaza, Ismail F.; Coperchini, Francesca; Rotondi, Mario; Chiovato, Luca; Afifi, Fatma U.

doi:10.1080/0972060x.2020.1729244

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…The indirect antiangiogenic activity was verified by assessing the effect on VEGF (Vascular endothelial growth factor) and HIF-1α (Hypoxia-inducible factor 1-alpha) mRNA (messenger RNA) and VEGF protein expression under normoxic and hypoxic conditions [ 34 , 35 ]. An anti-migratory effect by reducing CXCL8 (C-X-C Motif Chemokine Ligand 8) levels, a chemokine that contributes to CRC (colorectal cancer) cell proliferation and metastasis [ 36 ]. Lastly, several plants have decreased DNA oxidative damage and own radical scavenging properties [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants of Jordan: Scoping review

Abu-Odeh

Fino

Al-Absi

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Medicinal plants of Jordan: Scoping review

Abu-Odeh

Fino

Al-Absi

et al. 2023

Heliyon

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“…A significant anti-proliferation potential of P. atlantica against COLO205 has been noticed along with good antioxidant effect [25]. Colorectal cancer is one of the major malignant forms of cancer, which has been blocked by the essential oil from the P. palaestina [26]. The ethanol extract of P. atlantica demonstrated a significant effect against the gastric and cervical carcinoma along with antioxidant effect, which is attributed to the presence of phenolic compounds in the extract [27].…”

Section: Anticancer Effectmentioning

confidence: 99%

Pharmacological Investigation of Genus Pistacia

Rauf¹,

Al-Awthan²,

Muhammad³

et al. 2022

Natural Medicinal Plants

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Several plants in the genus Pistacia are used in the treatment of various pathogenic and non-pathogenic disorders. Especially important are the major species belonging to this genus such as Pistacia lentiscus, Pistacia atlantica, Pistacia vera, Pistacia terebinthus, and Pistacia khinjuk, among others; these have been reported for their potential benefits both in medical and commercial purposes. In addition, members of this genus exhibit numerous ethnomedicinal uses, such as analgesic, anti-inflammatory, anticancer, antimicrobial, antihypertension, antihyperlipidemic, antiviral, and antiasthma. In light of these potential uses, the present chapter aimed to collect and summarize the literature about all of this medicinal information. Accordingly, this chapter focuses on the pharmacological uses and benefits of the genus Pistacia, especially those related to health issues.

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“…Previous phytochemical studies on Pistacia have shown the presence of many secondary metabolites such as terpenoids (volatile oil, monoterpenoids, and sesquiterpenoids), phenolic compounds (gallic acid, flavonoids, anthocyanins), and sterols (𝛽-sitosterol, stigmasterol) 2 . Additionally, the importance of this genus comes from being a good source of vitamins, minerals, essential oils (EO), tannins, and resins [6][7][8] . These components display an important role in the pharmacological activity of P. palaestina, including anti-inflammatory, antifungal, antioxidant, and antimicrobial activities 9 .…”

Section: Introductionmentioning

confidence: 99%

“…However, there is only a few number of reports available in the literature. For instance, the composition of volatile oil of P. palaestina has been carried out by Awwad et al, 2004, using GC/MS, where the oil from the leaves with hydro-distillation consisted of 29.8% sabinene, 19.8% α-pinene, 13.1% β-pinene, and 10.3% α-terpineol 7 . In another study conducted by Flamini et al, 2020, in the same field, it was reported that the main compounds were myrcene (13,3%) and αpinene (63.1%) in the leaves and (Z)-ocimene (3.8-13.0%), sabinene (20.3-24.1%), and (E)-Ocimene (33.8-41.3%) in both ripe and unripe fruits 10 .…”

Section: Introductionmentioning

confidence: 99%

Qualitative Phytochemical Screening, Antioxidant and Wound Healing Activities of Pistacia Palaestina Boiss. Extracts

Alshlash¹,

Kitaz²,

Abdelwahed³

2023

Bulletin of Pharmaceutical Sciences. Assiut

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The current work was designed to undertake a qualitative phytochemical screening of various plant parts of Pistacia palaestina, and estimate antioxidant and wound healing activities for therapeutic applications. The qualitative phytochemical screening of the leaf and the fruit of P. palaestina was performed using different chemical tests. The total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were determined by using Folin-Ciocalteu, aluminum chloride, and DPPH (2,2-Diphenyl-1-picryl hydrazyl) methods, respectively. The extracts with the highest TPC and TFC were examined for their wound healing activity using an incision wound model on rats. The qualitative phytochemical screening revealed the presence of phenols, tannins, flavonoids, carbohydrates, saponins, phytosterols, terpenoids, mucilages, and resins, whereas no coumarins, alkaloids, cardiac glycosides, or anthraquinones were found. TPC and TFC were observed between (144.80 ± 8.81 to 489.79 ± 15.09 mg gallic acid equivalent (GAE)/g extract) and (18.34 ± 1.16 to 36.16 ± 1.05 mg rutin equivalent (RUE)/g extract), respectively. Methanolic extracts of leaves and fruits showed high antioxidant activity with IC50 about 5.16 ± 1.22 and 8.21 ± 1.87 μg/mL, respectively, which are slightly higher than ascorbic acid (IC50 = 3.52 ± 0.14 μg/mL). The prepared ointments from methanolic extracts significantly accelerated wound healing compared to a negative control group, as the final time of healing was 8.2 ± 1.30 (fruits), 9.6 ± 1.14 (leaves), 12 ± 1.22 (gentamicin ointment 0.1%) and more than 21 (negative control) days. In conclusion, P. palaestina could be used for the treatment of skin wounds.

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Effect of Pistacia palaestina Boiss. Essential Oil on Colorectal Cancer Cells: Inhibition of Proliferation and Migration

Cited by 6 publications

References 30 publications

Medicinal plants of Jordan: Scoping review

Medicinal plants of Jordan: Scoping review

Pharmacological Investigation of Genus Pistacia

Qualitative Phytochemical Screening, Antioxidant and Wound Healing Activities of Pistacia Palaestina Boiss. Extracts

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