2012
DOI: 10.1089/jmf.2012.2162
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Effect ofRosemarinus officinalisL. on MMP-9, MCP-1 Levels, and Cell Migration in RAW 264.7 and Smooth Muscle Cells

Abstract: Atherosclerosis is a chronic and progressive inflammatory disease. Novel anti-inflammatory therapies may have promise as treatment strategies for cardiovascular risk reduction. Rosemary (Rosemarinus officinalis L.) has been used in folk medicine to treat headaches, epilepsy, poor circulation, and many other ailments. It was found that rosemary could act as a stimulant and mild analgesic and could reduce inflammation. However, the mechanisms underlying the anti-inflammatory and antiatherosclerotic effects of ro… Show more

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Cited by 36 publications
(24 citation statements)
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“…Macrophages are immune effector cells and play a very important role in body's immune system. They are also central cells that initiate the production of in ammatory mediators in body [26][27][28]. LPS is the main product of Gram-negative bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…Macrophages are immune effector cells and play a very important role in body's immune system. They are also central cells that initiate the production of in ammatory mediators in body [26][27][28]. LPS is the main product of Gram-negative bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…MMP-9 is controlled by the inflammatory mediator NO and PGE 2 [5, 39]. Also, MMP-9 activity and expression were related to the ability of cell migration.…”
Section: Discussionmentioning
confidence: 99%
“…Rosemary, especially the leaf extract, is one of the most popular herbs, traditionally consumed as a culinary spice to adjust food flavor, and is widely used in the food and cosmetic industries as a natural antioxidant agent due to its inherently high antioxidant activity. Moreover, this plant has been used for centuries in folk medicine, and a wide variety of pharmacological activities have been attributed, such as hepatoprotective [84], antibacterial [85], anti-atherogenic [86], antidiabetic [87], antinociceptive [88][89], anti-inflammatory [89][90][91], anti-tumor [92,93] and antioxidant [94,95] activities. In addition, rosemary extracts and their isolated components have been shown to exert an antiproliferative effect on breast, liver, prostate, lung and colon cancer cells [96][97][98][99][100].…”
Section: Biological Activitiesmentioning
confidence: 99%
“…On the other hand, the literature on the therapeutic implications of rosemary in metabolic syndrome is also extensive since this aromatic plant possesses antidiabetic [87], anti-atherogenic [86] and hypocholesterolemic [103] activities, among others. These effects are basically related to the modulation of enzymes, transcriptional factors and the expression of key genes involved in several key metabolic pathways [104].…”
Section: Biological Activitiesmentioning
confidence: 99%