Effect of <i>Zingiber officinale</i> on lipid profile of sprague-dawley rats induced with streptozotocin

Hassan, Ndanusa Abdullahi; Karunakaran, Rohini; A, Uma Sankar; Aye, Khin Mar

doi:10.5958/0974-360x.2020.00632.0

Cited by 8 publications

(1 citation statement)

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“…It has been shown that body weight of diabetic rats reduced due to improper glucose metabolism, leading to break down of fats and proteins. 23,18 It is reported that 4-HIL regulates body weight effectively 12 which is in agreement with our results showing decrease in body weight of diabetic rats, while 4-HIL-treated rats have body weight close to that of non-diabetic rats.…”

Section: Discussionsupporting

confidence: 92%

Assessment of antidiabetic effect of 4-HIL in type 2 diabetic and healthy Sprague Dawley rats

et al. 2022

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Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia and insulin resistance. 4-hydroxyisoleucine (4-HIL) is a non-proteinogenic amino acid isolated from the fenugreek seeds and has enormous pharmacological activities. The present study was undertaken to investigate the antihyperglycemic effect of 4-HIL in streptozotocin (STZ)-induced diabetic rats. Moreover, its toxicity was evaluated in vitro and in vivo employing human embryonic kidney cells (HEK-293) and healthy rats, respectively. In experiment 1, STZ-induced diabetic male rats were subjected to an oral treatment of 4-HIL (100 mg/kg), while experiment 2 deals with the effects of 4-HIL on healthy male and female rats following oral administration. The treatment (experiment 1) declined the elevated blood glucose level, feed intake, and increased body weight(s). Additionally, blood glucose impairment was improved as observed by OGTT and IPGT tests. Pancreatic histopathology revealed mild changes in the 4-HIL group. Moreover, experiment 2 showed increased body weight, normal blood glucose levels (male—106.06 ± 7.49 mg/dl and female—100.06 ± 14.69 mg/dL), hematological parameters, and histopathological profiles in the treatment group. 4-HIL did not affect the viability of HEK-293 cells, and no signs of toxicity were observed in healthy rats. Therefore, the study concludes that 4-HIL has potential antihyperglycemic activity without any toxic effects.

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Section: Discussionsupporting

confidence: 92%

Assessment of antidiabetic effect of 4-HIL in type 2 diabetic and healthy Sprague Dawley rats

et al. 2022

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In-vitro and in vivo studies of traditionally prepared Zingiber officinale juice for Antimitotic and Lethality activity

Sowmya

Singh

Patel

et al. 2021

RJPT

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According to the literature survey most of the studies done on Adarak (Zingiber officinale rhizome) were performed on alcoholic extracts or isolated entities of ginger but no profound work has been done on the traditionally prepared or commonly consumed way of ginger. So, in this current study, fresh ginger rhizomes were traditionally pounded to make Adarak juice. The different concentration (0.05%, 0.5%, 1%, 2.5%, 5%, 10%) were taken as sample to perform onion root tip inhibition assay and brine shrimp lethality bioassay. It showed antimitotic inhibition in the range of 0.05-10% concentration with an IC50 value of 0.37 % on number of rootlets was 0.08 % on length of rootlets. The traditionally prepared Adarak juice showed cytotoxicity in the range of 0.05-2.5% concentration with LC50 value of 1.59%. The traditionally prepared Adarak juice possesses cytotoxic and antimitotic activity.

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Hypolipidemic Effect of The Fruit Juice of Hippophae rhamnoides L. (Seabuckthorn) in Hypercholesteremic New Zealand Rabbits Model

Praharaj

Kalaichelvan

Murugan

et al. 2022

RJPT

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Hypolipidemic effect of fruit juice of Hippophae rhamnoides L was evaluated in 1% cholesterol and 10% ground nut oil diet induced hyper cholesteremic models of New Zealand rabbits. The fruit juice at 0.46ml/kg body weight reduced the elevated serum total cholesterol (TC), triglyceride, low density cholesterol (LDL-C), atherogenic index, and C - reactive protein levels on diet induced rabbits. The juice at the same dose significantly enhanced the high density lipoprotein (HDL) in high fat diet (HFD) induced hyperlipidemic rabbits. The reference compound atorvastatin showed significant (p<0.05) effects.

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Effect of Zingiber officinale on lipid profile of sprague-dawley rats induced with streptozotocin

Cited by 8 publications

References 0 publications

Assessment of antidiabetic effect of 4-HIL in type 2 diabetic and healthy Sprague Dawley rats

Assessment of antidiabetic effect of 4-HIL in type 2 diabetic and healthy Sprague Dawley rats

In-vitro and in vivo studies of traditionally prepared Zingiber officinale juice for Antimitotic and Lethality activity

Hypolipidemic Effect of The Fruit Juice of Hippophae rhamnoides L. (Seabuckthorn) in Hypercholesteremic New Zealand Rabbits Model

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