Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech adult population

Vašků, Julie Bienertová; Bienert, Petr; Sablikova, Lenka; Slovackova, Lenka; Forejt, Martin; Piskáčková, Zlata; Kučerová, Lenka; Heczková, Kateřina; Brázdová, Zuzana Derflerová; Vašků, Anna

doi:10.1007/s12263-009-0130-9

Cited by 13 publications

(20 citation statements)

References 32 publications

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“…Associations between ACE I/D and obesity parameters show the same controversy regarding the risk allele. For instance, in the study of Bienertova-Vasku et al (2009), the II-genotype was found associated with the prevalence of obesity, whereas Settin et al (2009) reported a significantly higher BMI in D-allele carriers. It has also been shown that subjects with the D/D genotype lose less body fat with similar amounts of weight loss than I-allele carriers (Hamada et al 2011).…”

Section: Discussionmentioning

confidence: 97%

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

et al. 2014

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Weight gain, when it leads to overweight or obesity, is nowadays one of the major health problems. ACE, FTO, AKR1C2, TIMP4 and MMP2 genes have been implicated in previous studies on weight regulation. This study investigated the contribution of polymorphisms in these five candidate genes to the risk of weight gain over a 10-year time period. Two groups were selected from participants of the Doetinchem cohort study who were followed over a 10-year period: A stable weight group (±2 kg/10 year; n = 259) and a weight gainers group who increased their body weight by roughly 10 % ([8 kg/ 10 year; n = 237). Starting BMI was between 20 and 35 kg/m 2 and baseline age between 20 and 45 years. Selected SNPs and insert/deletion in candidate genes were measured in each group. In men, the allelic distribution of FTO rs9939609 (v 2 p = 0.005), ACE rs4340 (v 2 p = 0.006) and AKR1C2 rs12249281 (v 2 p = 0.019) differed between the weight stable and weight gainers group. Interaction between FTO rs9939609 and ACE rs4340 was observed. In women, the allelic distribution of MMP2 rs1132896 differed between the weight stable and weight gainers group (v 2 p = 0.00001). The A-allele of FTO was associated with a 1.999 higher risk of gaining weight in men (OR 1.99, p = 0.020), while in women, the C-allele of MMP2 was associated with a 2.509 higher risk of weight gain (OR 2.50, p = 0.001) over the 10-year period. We found that FTO in men and MMP2 in women are associated with weight gain over a 10-year follow-up period.

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Section: Discussionmentioning

confidence: 97%

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

et al. 2014

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“…It is well known that childhood overweight and obesity have increased in many developed countries [3][4][5] due to the imbalance between caloric intake and energy expenditure [6,7].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children

et al. 2014

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“…12 However, there is also a controversial study indicating that it is not the DD-but the II-genotype that is related to the prevalence of obesity. 13 The possible explanations for such contradictory findings include the interaction with other genes or environmental factors. 5 Recently, via targeted proteomic screening, we have found that the circulating level of ACE is an important predictor of weight loss maintenance after weight loss induced by low-caloric diet (LCD) in overweight/obese female participants of the Diogenes project, 14 a pan-European dietary intervention study in overweight/obese families.…”

Section: Introductionmentioning

confidence: 99%

Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men

et al. 2012

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, on behalf of Diogenes consortium 14 BACKGROUND: Circulating angiotensin-converting enzyme (ACE) was identified as a predictor of weight loss maintenance in overweight/obese women of the Diogenes project. OBJECTIVE: To investigate whether ACE acted also as a predictor in men of the Diogenes study and to compare it with that in women. DESIGN: Subjects, who lost X8% of body weight induced by low-caloric diet in an 8-week weight loss period, were assigned to weight loss maintenance with dietary intervention for 6 months. SUBJECTS: 125 overweight/obese healthy men from eight European countries who completed whole intervention. MEASUREMENTS: Concentrations and activity of serum ACE at baseline and after the 8-week weight loss, in addition to anthropometric and physiological parameters. RESULTS: Serum ACE concentration decreased by 11.3±10.6% during the weight loss period in men. A greater reduction is associated with less body weight regain during the maintenance period (r ¼ 0.227, P ¼ 0.012). ACE change was able to predict a weight regain p20% after 6 months, with an odds ratio of 1.59 (95% confidence interval (CI): 1.09 --2.33, P ¼ 0.016) for every 10% reduction, which was independent of body mass index and weight loss. The prediction power was weaker in men than in women, but without a significant sex difference (P ¼ 0.137). In pooled subjects (N ¼ 218), the odds ratio was 1.96 (95% CI: 1.46 --2.64, Po0.001). CONCLUSIONS: A greater reduction of ACE during weight loss is favorable for weight maintenance in both men and women. This can offer useful information for personalized advice to improve weight loss maintenance. It also confirms the role of ACE in the metabolic pathways of weight regulation.

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Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech adult population

Cited by 13 publications

References 32 publications

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

Angiotensin-converting enzyme gene insertion/deletion polymorphism in nutritional disorders in children

Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men

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