Effect of IFN-γ, IL-12 and IL-10 cytokine production and mRNA expression in tuberculosis patients with diabetes mellitus and their household contacts

Ponnana, Meenakshi; Ramya, S; Lavanya, Joshi; Vijayalakshmi, V.; Gaddam, Sumanlatha

doi:10.1016/j.cyto.2016.03.009

Cited by 23 publications

(24 citation statements)

References 47 publications

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“…After the patient was stimulated by the tuberculosis antigen, the (Meenakshi, Ramya, Lavanya, Vijayalakshmi, & Sumanlatha, 2016). In addition, hyperglycemia could inhibit the There are some limitations in this study.…”

Section: Discussionmentioning

confidence: 91%

The correlation between CT features and insulin resistance levels in patients with T2DM complicated with primary pulmonary tuberculosis

Yang

Wang

Mao

et al. 2020

Journal Cellular Physiology

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The aim is to investigate the correlation between computed tomography (CT) features and insulin resistance levels in patients with type 2 diabetes mellitus (T2DM) complicated with primary pulmonary tuberculosis (PTB). Nearly, 268 untreated PTB patients complicated with T2DM were divided into two groups according to the optimal cutoff value of HOMA‐IR score for the Chinese population: HOMA‐IR ≤ 2.69 (Group I: 74 patients), >2.69 (Group II: 194 patients). The basic characteristics and changes of CT manifestations were analyzed. In the two groups, the detection rate of large segmented leafy shadow was 39.2% and 78.9%; the air bronchogram sign detection rate was 40.5% and 80.9%; the discovery rate of mouth‐eaten cavity was 33.8% and 73.7%; the thin‐walled cavity detection rate was 2.7% and 16.0%; the rate of multiple cavities was 35.1% and 69.6%; and bronchial tuberculosis was found in 4.1% and 35.6%, respectively. The detection rates of lesions in Group II were significantly higher than in Group I (p < .05). HOMA‐IR was found independently associated with large segmented leafy shadow, air bronchial sign, thin‐walled cavity, and bronchial tuberculosis. The level of insulin resistance can effectively reflect the severity of PTB patients with T2DM. CT scan can directly provide image information in clinics. These two examinations can guide clinicians to accurately formulate subsequent treatment plans.

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Section: Discussionmentioning

confidence: 91%

The correlation between CT features and insulin resistance levels in patients with T2DM complicated with primary pulmonary tuberculosis

Yang

Wang

Mao

et al. 2020

Journal Cellular Physiology

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“…M1 macrophages often increase production of inflammatory cytokines such as IL‐12 and IL‐1β, whereas M2 macrophages often produce the anti‐inflammatory cytokine IL‐10 and TGF‐β . It has been reported that IL‐1 and IL‐12 confer host resistance to Mtb , whereas IL‐10 and TGF‐β facilitate Mtb escape from immune attack . Nigou et al .…”

Section: Discussionmentioning

confidence: 99%

A single‐stranded DNA aptamer against mannose‐capped lipoarabinomannan enhances anti‐tuberculosis activity of macrophages through downregulation of lipid‐sensing nuclear receptor peroxisome proliferator‐activated receptor γ expression

Pan

Yan

Liu

et al. 2017

Microbiology and Immunology

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Mannose-capped lipoarabinomannan (ManLAM) is an immunomodulatory epitope of Mycobacterium tuberculosis (Mtb). An aptamer (ZXL1) that specifically binds to ManLAM from the virulent Mtb H37Rv strain was previously generated and it was found that ZXL1 functions as an antagonist, inhibiting the ManLAM-induced immunosuppression of DCs. In the present study, it was found that ZXL1 inhibits Mtb entry into murine macrophages and that ZXL1 enhances IL-1β and IL-12 mRNA expression and cytokine production in ManLAM-treated macrophages but decreases IL-10 production. Inducible nitric oxide synthase expression in macrophages was upregulated in the presence of ZXL1 after stimulation with ManLAM. ZXL1 was also found to inhibit expression of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ). These results suggest that ZXL1 promotes anti-tuberculosis activity through downregulation of PPAR-γ expression, which may contribute to M1 macrophage polarization and Mtb killing by macrophages.

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“…The CD4 + Th1 cells ware activated and produced cytokines classically such as IL-2, IFN-γ and TNF-α, which involved in the protection role in tuberculosis 33 . Among Th1 type cytokines, IFN-γ and TNF-α were identified as the most important agents of the antimycobacterial cytokine cascade 34 . In current study, the levels of IFN-γ and TNF-α in lungs were significantly increasing in BCG-infected mice treated with rAd-hMASP-2.…”

Section: Discussionmentioning

confidence: 99%

Effects of hMASP-2 on the formation of BCG infection-induced granuloma in the lungs of BALB/c mice

Lü

Dong

et al. 2017

Sci Rep

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Tuberculosis, caused by Mycobacterium tuberculosis, affects the functions of the lung and causes high morbidity and mortality rates worldwide. MASP-2 is an executioner enzyme, which plays an essential role in the activation of lectin pathway. In our previous studies, the MASP-2 played a dual role in promoting the progress of lesions in BCG-infected rabbit skin models. However, the really effects of MASP-2 on tuberculosis are unknown. The aim of this study was to investigate the effects of MASP-2 in granuloma formation with BCG-infected mice. Compared to the control group, rAd-hMASP-2 treated group showed increasing in survival rate of BCG-infected mice (P = 0.042), and decreasing of bacteria loads (P = 0.005) in the lung tissue. MASP-2 displayed a protective efficacy in BCG-infected mice, which promoted the activation and recruitment of macrophages and lymphocytes to the granuloma. Moreover, the data obtained from the ELISA and RT-PCR demonstrated that mRNA expression for IL-6, CCL12, CCL2 and cytokines of IFN-γ, TNF-α in lung were significantly elevated by treatment of rAd-hMASP-2. Those findings provided an evidence that MASP-2 may be as a newly immunomodulatory in targeting granuloma formation, which displayed a potential protective role in control of tuberculosis.

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Effect of IFN-γ, IL-12 and IL-10 cytokine production and mRNA expression in tuberculosis patients with diabetes mellitus and their household contacts

Cited by 23 publications

References 47 publications

The correlation between CT features and insulin resistance levels in patients with T2DM complicated with primary pulmonary tuberculosis

The correlation between CT features and insulin resistance levels in patients with T2DM complicated with primary pulmonary tuberculosis

A single‐stranded DNA aptamer against mannose‐capped lipoarabinomannan enhances anti‐tuberculosis activity of macrophages through downregulation of lipid‐sensing nuclear receptor peroxisome proliferator‐activated receptor γ expression

Effects of hMASP-2 on the formation of BCG infection-induced granuloma in the lungs of BALB/c mice

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