Effect of immunological enhancement of aloe polysaccharide on chickens immunized with Bordetella avium inactivated vaccine

Sun, Zhonghua; Wei, Kai; Yan, Zhiying; Zhu, Xiaocui; Wang, Xinjian; Wang, Hui; Tan, Yaohong; Sheng, Pengcheng; Zhu, Rui‐Liang

doi:10.1016/j.carbpol.2011.05.012

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…In one of the newest researches conducted by Sun, Wei et al . () polysaccharide compounds extracted from Aloe vera gel were used as an injectable adjuvant for inducing higher immunity against Bordetella avium in 1 day old broiler chicks (Sun, Wei et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Same amounts of Aloe vera solution and bacterin stock were totally mixed (i.e. 50:50 v:v ratio) (Habeeb, Stables, Bradbury & Nong 2007;Sun, Wei et al 2011).…”

Section: Vaccine Preparationmentioning

confidence: 99%

“…Aloe vera gel is the mucilaginous gel from the parenchymatous leaf pulp of Aloe barbadensis which has widespread application in medicine (Reynolds & Dweck 1999). It acts as a broad-spectrum immunoregulator which can activate immunocytes, regulate the release of cytokine, promote the generation of antibody and enhance the immunological function of leucocytes (Lee, Lee, Yun, Kim & Kim 2001;Sun, Wei, Yan, Zhu & Wang 2011). Acemannan, the main functional component of Aloe vera gel (Lee et al 2001), can bind to macrophages and exhibits strong tumour suppressor and adjuvant properties (Lee 1988;Peng, Norman, Curtin, Corrier, McDaniel & Busbee 1991).…”

Section: Introductionmentioning

confidence: 99%

“…Activation of macrophages by Aloe vera gel results in releasing various cytokines such as IL-1, IL-6 and TNF-a and enhancing T-cellmediated cytotoxicity and proliferation (Wonbel & Helderman 1988;Djeraba & Quere 2000). Adjuvant function of Aloe vera gel has been described in vaccination against avian viral and bacterial diseases such as Newcastle disease, Marek's disease and Bordetellosis (Chinnah, Baig, Tizard & Kemp 1992;Sun, Wei et al 2011). Although the immunomodulatory potentials of Aloe vera in different species particularly in human and mammals have been well confirmed (Tan & Vanitha 2004), few works were done on effects of Aloe vera in fish and there are no data about the efficacy of Aloe vere gel as vaccine adjuvant in fish (Kim, Hwang & Bai 1999;Alishahi, Ranjbar, Ghorbanpour, Peyghan, Mesbah & Razijalali 2010).The purpose of this study was to investigate the comparative effect of Freund's and Aloe vera gel as adjuvants on the expression of immune-related genes (IL-1b and TNF-a) in vaccinated common carp with A. hydrophila bacterin.…”

Section: Introductionmentioning

confidence: 99%

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Comparative effect of Freund's adjuvant andAloe veraL. gel on the expression of TNF-α and IL-1β in vaccinatedCyprinus carpioL. withAeromonas hydrophilaC. bacterin

et al. 2015

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The comparative effects of Freund's and Aloe vera gel as adjuvants on the expression of IL-1b and TNF-a genes were studied in vaccinated common carp (Cyprinus carpio) with Aeromonas hydrophila bacterin. Fishes were intraperitoneally immunized with A. hydrophila bacterin in combination with Aloe vera gel or Freund's and also without any adjuvant. At day 28 after immunization, all groups were challenged by lethal dose of A. hydrophila (10 7 cells/ fish). Changes in the expression of IL-1b and TNF-a genes were evaluated in anterior kidney before challenge and 12, 24, 72 and 7 days postchallenge using quantitative real-time PCR. Higher expression levels of both genes were observed in all vaccinated groups compared with non-immunized group. Fishes which received Aloe vera gel showed higher expression of IL-1b and TNF-a in relation to animals which vaccinated with or without Freund's adjuvant. We concluded that Aloe vera gel in compared with Freund's adjuvant had a more stimulatory effect on the expression of immune-related genes in vaccinated common carp and it can use as a novel adjuvant in aquaculture.

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Section: Discussionmentioning

confidence: 99%

“…Same amounts of Aloe vera solution and bacterin stock were totally mixed (i.e. 50:50 v:v ratio) (Habeeb, Stables, Bradbury & Nong 2007;Sun, Wei et al 2011).…”

Section: Vaccine Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative effect of Freund's adjuvant andAloe veraL. gel on the expression of TNF-α and IL-1β in vaccinatedCyprinus carpioL. withAeromonas hydrophilaC. bacterin

et al. 2015

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“…Further, the immunological efficacy of aloe was reported by a number of investigators, as evidenced by (1) enhancement of the vaccine effects, (2) amelioration of oral ulcers in an animal model, (3) antiinflammatory action on colitis in rats, and (4) reduction of the severity of mucositis associated with cancer therapy (Sun et al, 2011;Park et al, 2011;Worthington et al, 2011). Aloe vera suppressed the growth of Candida albicans significantly, probably due to its active ingredients (Bernardes et al, 2012;Im et al, 2010;Msoffe and Mbilu, 2009).…”

mentioning

confidence: 89%

The No-Observed-Adverse-Effect Level (NOAEL) of Baby Aloe Powder (BAP) for Nutraceutical Application Based Upon Toxicological Evaluation

Kwack

Gil

Kim

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Aloe has been used in versatile herbal medications and nutraceuticals throughout history. Aloe is widely considered to be generally safe for humans and used globally. The effectiveness and pharmacological properties of aloe are dependent upon when the plant is collected. However, little is known about the toxicology of whole-body aloe collected within less than 1 yr. Based upon widespread exposure to aloe, it is important to determine a daily intake level of this chemical to ensure its safety for humans. To determine the no-observed-adverse-effect level (NOAEL) of baby aloe powder (BAP) for clinical application, Sprague-Dawley (SD) rats were treated orally for 4 wk with 4 different concentrations: 0, 0.125, 0.5, and 2 g/kg body weight (bw). In this study, no significant or dose-dependent toxicological effects of BAP were observed in biochemical or hematological parameters, urinalysis, clinical signs, body weight, and food and water consumption. There were changes in some biomarkers in certain treated groups compared to controls; however, all values were within their reference ranges and not dose-dependent. Based on these results, the NOAEL of BAP was estimated to be greater than 2 g/kg bw in male and 2 g/kg bw in female SD rats. Collectively, these data suggest that BAP used in this study did not produce any marked subacute toxic effects up to a maximum concentration of 2 g/kg bw, and thus use in nutraceuticals and in pharmaceutical and cosmetic applications at a concentration of >2 g/kg is warranted.

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Comparative effects of Aloe vera gel and Freund’s adjuvant in vaccination of common carp (Cyprinus carpio L.) against Aeromonas hydrophila

et al. 2016

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Effect of immunological enhancement of aloe polysaccharide on chickens immunized with Bordetella avium inactivated vaccine

Cited by 21 publications

References 16 publications

Comparative effect of Freund's adjuvant andAloe veraL. gel on the expression of TNF-α and IL-1β in vaccinatedCyprinus carpioL. withAeromonas hydrophilaC. bacterin

Comparative effect of Freund's adjuvant andAloe veraL. gel on the expression of TNF-α and IL-1β in vaccinatedCyprinus carpioL. withAeromonas hydrophilaC. bacterin

The No-Observed-Adverse-Effect Level (NOAEL) of Baby Aloe Powder (BAP) for Nutraceutical Application Based Upon Toxicological Evaluation

Comparative effects of Aloe vera gel and Freund’s adjuvant in vaccination of common carp (Cyprinus carpio L.) against Aeromonas hydrophila

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