Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: A six-year prospective study

Gleich, Gerald J.; Zimmermann, Ellen M.; Henderson, Lowell L.; Yunginger, John W.

doi:10.1016/0091-6749(82)90062-8

Cited by 235 publications

(138 citation statements)

References 26 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…(12) who demonstrated that in vitro production of rye group 1 specific IgE antibodies by human PBL only occurred during the pollination period. This seasonal increase in specific IgE synthesis in vitro was proportionally greater than in plasma where, in contrast to data reported by others (18), no consistent seasonal changes were observed ( Table 1). Fractionation of B cells on Percoll gradients greatly increased the number of actively synthesizing cultures in certain density bands, particularly in the October cultures and noticeably in fraction B5 when five of six cultures were positive compared with two of six cultures of unfractionated B cells (Table 4).…”

Section: Discussioncontrasting

confidence: 56%

Festschrift In vitro synthesis of IgE by human peripheral blood leucocytes: VI Seasonal variations in synthesis of rye pollen (Lolium perenne) specific IgE

Turner

Siemensma²,

Krska³

et al. 1988

Immunol Cell Biol

View full text Add to dashboard Cite

Summary Fractionation by Percoll density cetrifugation of peripheral blood leucocyte cells, from atopic subjects with seasonal hay fever, unmasked IgE-B cell populations whose individual capacities to synthesize IgE in vitro were obscured in cultures of unfractionated B cells. B cell cultures from all six subjects in the study released rye pollen-specific IgE during the 6 days of culture, but actual synthesis was significant only in October, the pollen season. Synthesis in October occurred most frequently in cultures of mature, low density B cells, which generally responded to the addition of autologous T cells with enhanced synthesis (T-help). T-help was also found for high density B ceils in the mid-winter (July) cultures. Total IgE synthesis in vitro demonstrated a less seasonal relationship, although it tended to be maximal for low density B cell cultures in October and for high density B cells in May. All B cell cultures contained preformed total and rye-specific IgE antibody which persisted throughout the pre-and post-pollen seasons, particularly in the low density B cell fractions, even in the absence of de novo synthesis. Moreover, the intraceilular levels of rye pollen-specific IgE antibody were often higher in the winter than in the peak of the pollen season. The relevance of this preformed IgE remains to be established.

show abstract

Section: Discussioncontrasting

confidence: 56%

Festschrift In vitro synthesis of IgE by human peripheral blood leucocytes: VI Seasonal variations in synthesis of rye pollen (Lolium perenne) specific IgE

Turner

Siemensma²,

Krska³

et al. 1988

Immunol Cell Biol

View full text Add to dashboard Cite

show abstract

“…Desensitization frequently induces a transient increase in serum specific IgE, followed by gradual decrease over months or years of treatment (1,28,29). In pollen-sensitive patients, desensitization prevented elevation of the serum specific IgE titer during the pollen season (30,31). However, the changes in IgE levels can hardly explain the diminished responsiveness to specific allergen due to SIT, since the decrease in serum IgE is late, is relatively small, and is poorly correlated with clinical improvement after SIT (31).…”

Section: Efltect On Serum Immunoglobulinsmentioning

confidence: 97%

“…In pollen-sensitive patients, desensitization prevented elevation of the serum specific IgE titer during the pollen season (30,31). However, the changes in IgE levels can hardly explain the diminished responsiveness to specific allergen due to SIT, since the decrease in serum IgE is late, is relatively small, and is poorly correlated with clinical improvement after SIT (31). A certain reevaluation of the previous findings might be necessary, since the radioallergosorbent test (RAST) for the whole allergen may not always indicate the development of IgE against particular major allergens.…”

Section: Efltect On Serum Immunoglobulinsmentioning

confidence: 99%

Mechanisms of specific immunotherapy of allergic diseases

Kowalski

Jutel

1998

Allergy

View full text Add to dashboard Cite

“…In patients with seasonal allergies, IgE antibodies continue to be produced between one season and the next when re-exposure to the allergen boosts their IgE and IgG response. 35 …”

Section: When and Where Does Class Switching Occur?mentioning

confidence: 99%

The role of the T follicular helper cells in allergic disease

Kemeny

2012

Cell Mol Immunol

View full text Add to dashboard Cite

DM KemenyT follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells.

show abstract

Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: A six-year prospective study

Cited by 235 publications

References 26 publications

Festschrift In vitro synthesis of IgE by human peripheral blood leucocytes: VI Seasonal variations in synthesis of rye pollen (Lolium perenne) specific IgE

Festschrift In vitro synthesis of IgE by human peripheral blood leucocytes: VI Seasonal variations in synthesis of rye pollen (Lolium perenne) specific IgE

Mechanisms of specific immunotherapy of allergic diseases

The role of the T follicular helper cells in allergic disease

Contact Info

Product

Resources

About