Effect of in vivo T-cell depletion on the effector T-cell function of immunity to Eimeria falciformis

Stiff, Mary I.; Vasilakos, John P.

doi:10.1128/iai.58.6.1496-1499.1990

Cited by 22 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase of CD4 cells that we found after primary infection suggests that these cells together with macrophages are involved in the induction of the immune response, whereas the increase of CD8 cells after challenge infection suggests that these cells act as effector cells. The correlation between our findings concerning the changes in LPL subsets and the results found after depletion and transfer studies in mice (Rose et al 1988a, 1988b, Stiff & Vasilakos 1990) suggest comparable immune responses to different Eimeria spp. However, immunity to reinfection is species specific since cross-protection between spp.…”

supporting

confidence: 85%

In situ characterization of leucocyte subpopulations after infection with Eimeria tenella in chickens

Vervelde¹,

Vermeulen²,

Jeurissen³

1996

Parasite Immunology

View full text Add to dashboard Cite

We characterized the leucocyte subpopulations after infection with Eimeria tenella in both naive and immune chickens. Immunocytochemical staining was used to characterize the cells in situ, so that the interaction between host and parasite could be studied. More leucocytes were detected in the lamina propria of immune chickens, and leucocytes infiltrated the ceca more rapidly than in naive chickens, but the infiltration was less pronounced than in naive chickens. In naive chickens, most infiltrated leucocytes were macrophages and T cells. Two days after inoculation the number of CD4+ cells had increased greatly. In immune chickens, mainly T cells (CD4+ and CD8+) infiltrated the lamina propria, and in contrast to naive chickens, the number of CD8+ cells exceeded the number of CD4+ cells. Furthermore, we characterized which cells contained a parasite and which cells were detected next to the parasites, because these cells are probably involved in the arrested development of the parasites. In naive chickens, sporozoites were significantly more often located within or next to macrophages than in immune chickens. In immune chickens, sporozoites were significantly more often located within or next to CD3+, CD8+, and TCR2+ cells. In conclusion, the marked increase of CD4+ cells after primary infection suggests that these cells are involved in the induction of the immune response, whereas the increase of CD8+ cells after challenge infection suggests that these cells act as effector cells.

show abstract

supporting

confidence: 85%

In situ characterization of leucocyte subpopulations after infection with Eimeria tenella in chickens

Vervelde¹,

Vermeulen²,

Jeurissen³

1996

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…Athymic mice and rats experience more severe primary infections and have no resistance to reinfection (83). Furthermore, a partial in vivo depletion of mouse T cells with antibody to Thy 1.2 antigen resulted in an abrogation of protective immunity to E. falciformis and extended the patent period (105). Similarly, depletion of CD4 ϩ cells by in vivo treatment with anti-CD4 MAb increased the severity of primary E. vermiformis infection but had no effect in animals with established immunity (88).…”

Section: Host Immune Responsesmentioning

confidence: 99%

Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Lillehoj¹,

Trout²

1996

Clin Microbiol Rev

294

144

View full text Add to dashboard Cite

Coccidiosis, an intestinal infection caused by intracellular protozoan parasites belonging to several different species of Eimeria, seriously impairs the growth and feed utilization of livestock and poultry. Host immune responses to coccidial infection are complex. Animals infected with Eimeria spp. produce parasite-specific antibodies in both the circulation and mucosal secretions. However, it appears that antibody-mediated responses play a minor role in protection against coccidiosis. Furthermore, there is increasing evidence that cell-mediated immunity plays a major role in resistance to infection. T lymphocytes appear to respond to coccidial infection through both cytokine production and a direct cytotoxic attack on infected cells. The exact mechanisms by which T cells eliminate the parasites, however, remain unclear. Although limited information is available on the intestinal immune system of chickens, gut lymphoid tissues have evolved specialized features that reflect their role as the first line of defense at mucosal surfaces, including both immunoregulatory cells and effector cells. This review summarizes our current understanding of the avian intestinal immune system and mucosal immune responses to Eimeria spp., providing an overview of the complex cellular and molecular events involved in intestinal immune responses to enteric pathogens.

show abstract

“…T cells have been shown to play a major role in the defense against E . falciformis infection (Mesfin & Bellamy, 1979; Stiff & Vasilakos, 1990). Following infection, interferon γ (IFNγ) is upregulated (Schmid et al, 2013) and experimental infections showed higher weight loss and pathology but lower oocysts shedding in IFNγ‐deficient mice than in wild type (Stange et al, 2012).…”

Section: Eimeria Spp As New Model Parasites To Assess Resistance Heal...mentioning

confidence: 99%

“…Host defense mechanisms against this parasite are well studied (Mesfin & Bellamy, 1979;Pogonka et al, 2010;Schmid et al, 2013) and its whole genome is sequenced and annotated (Heitlinger et al, 2014). T cells have been shown to play a major role in the defense against E. falciformis infection (Mesfin & Bellamy, 1979;Stiff & Vasilakos, 1990). Following infection, interferon γ (IFNγ) is upregulated (Schmid et al, 2013) and experimental infections showed higher weight loss and pathology but lower oocysts shedding in IFNγ-deficient mice than in wild type (Stange et al, 2012).…”

Section: Ei M Eria S Pp a S Ne W Model Par A S Ite S To A Ss E Ss Re ...mentioning

confidence: 99%

Shifting focus from resistance to disease tolerance: A review on hybrid house mice

Balard

Heitlinger

2022

Ecology and Evolution

View full text Add to dashboard Cite

show abstract

Effect of in vivo T-cell depletion on the effector T-cell function of immunity to Eimeria falciformis

Cited by 22 publications

References 21 publications

In situ characterization of leucocyte subpopulations after infection with Eimeria tenella in chickens

In situ characterization of leucocyte subpopulations after infection with Eimeria tenella in chickens

Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Shifting focus from resistance to disease tolerance: A review on hybrid house mice

Contact Info

Product

Resources

About