Effect of indomethacin on the pregnant rat

Abstract

ABSTRACT

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats

“…In this study, SD rats received 4.33, 4.66 and 5.00 mg/kg bwt of IMC on Pd3 and Pd4, demonstrating maternal toxicity. These data are consistent with the findings of a previous study ( Damasceno et al, 2008 ) which demonstrated a decrease in feed intake and body weight from Pd6 to Pd11 in SD rats administered an IMC dose of 8.50 mg/kg bwt. In addition, IMC treatment has an adverse effect on the smooth muscles of the small intestine and a reduced number of embryos were observed.…”

“…In another study, Both pre-and post-implantation losses increased significantly at a dose of 10 mg/kg/day ( Shafiq et al, 2004 ). The reproductive health of Wister rats was not affected at lower doses of 0.32, 1, and 1.68 mg/kg bwt twice daily from Pd3 to Pd5 ( Damasceno et al, 2008 , Kennedy, 1977 ). EIS was significantly reduced in all rat groups treated with IMC in the current study.…”

“…In the current study a significant drop in EIS was observed in IMC doses 4.66 and 5.00 mg/kg bwt were observed when compared to control group. Furthermore, the toxic dam-age to uterine tissues caused by IMC may contribute to the loss of implantations in the treated groups by impairing the ability of endometrial cells to produce PG ( Damasceno et al, 2008 ). The effect of IMC has been attributed to its ability to inhibit PG synthesis in the uterus ( Bergström, 2014 ).…”

“…The number of EIS was reduced in studies with IMC doses of 3 and 5 mg/kg bwt administered twice daily from Pd3 to Pd5 ( Phillips & Poyser, 1981 ). Toxic gastrointestinal hemorrhage and fatalities have been reported at 8.40 mg/kg/day and 10 mg/kg/day ( Damasceno et al, 2008 , Salleh, 2014 , Shafiq et al, 2004 ). In another study, Both pre-and post-implantation losses increased significantly at a dose of 10 mg/kg/day ( Shafiq et al, 2004 ).…”

Sex hormones and sperm parameters of male white rats treated with amlodipine

“…Abnormal Sperm Percent: The sperm was examined and the normal appearance was distinguished from the distorted by the head or tail or both to calculate the abnormal sperm. The same slide was used that was used to calculate the dead and live sperm, and to determine the abnormal appearance of the sperm, the following equation is calculated: (Deformation% = Abnormal number of sperms / Total number of sperms X 100), (Dale and Edler, 1997), (Damascono et al, 2008).…”