Effect of influenza vaccine on COVID-19 mortality: a retrospective study

Candelli, Marcello; Pignataro, Giulia; Torelli, Enrico; Gullì, Antonio; Nista, Enrico Celestino; Petrucci, Martina; Saviano, Angela; Marchesini, Debora; Covino, Marcello; Ojetti, Veronica; Antonelli, Massimo; Gasbarrini, Antonio; Franceschi, Francesco

doi:10.1007/s11739-021-02702-2

Cited by 73 publications

(77 citation statements)

References 26 publications

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“…Different studies have shown a significant inverse association between influenza vaccination and severity of COVID-19 in terms of hospitalized patients, ICU admissions, and deaths attributable to the virus [5][6][7], raising the possibility that the influenza vaccine may activate the immune system sufficiently to prevent infection (by any virus) in a window after vaccination [4]. It was suggested that this could occur if the vaccine is able to sufficiently stimulate innate immunity against respiratory viruses, including SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2021

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A single-center, randomized, double-blind, placebo-controlled study was conducted in 72 volunteers who received a synergistic combination of yeast-based ingredients with a unique β-1,3/1,6-glucan complex and a consortium of heat-treated probiotic Saccharomyces cerevisiae rich in selenium and zinc (ABB C1®) or placebo on the next day after getting vaccinated against influenza (Chiromas®) (n = 34) or the COVID-19 (Comirnaty®) (n = 38). The duration of treatment was 30 and 35 days for the influenza and COVID-19 vaccine groups, respectively. Mean levels of CD4+T cells increased from 910.7 at baseline to 1000.2 cells/µL after the second dose of the COVID-19 vaccine in the ABB C1® group, whereas there was a decrease from 1055.1 to 929.8 cells/µL in the placebo group. Changes of CD3+T and CD8+T lymphocytes showed a similar trend. In the COVID-19 cohort, the increases in both IgG and IgM were higher in the ABB C1® supplement than in the placebo group. Serum levels of selenium and zinc showed a higher increase in subjects treated with the active product than in those receiving placebo. No serious adverse events related to ABB C1® or tolerance issues were reported. The study findings validate the capacity of the ABB C1® product to stimulate trained immunity.

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Section: Introductionmentioning

confidence: 99%

Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2021

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“…Moreover, the induction of trained immunity and its effects in the pathogenesis of autoinflammatory diseases has been an important tool in the management of serious viral infections, such as COVID-19 [ 191 ]. Based on this evidence, other researchers have also evaluated the role of influenza vaccination as an indirect system useful to increase the body’s defenses against COVID-19 [ 192 , 193 ].…”

Section: Discussionmentioning

confidence: 99%

Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative Immunity

Marcuzzi

Melloni

Zauli

et al. 2021

IJMS

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Innate and adaptive immune responses have a well-known link and represent the distinctive origins of several diseases, many of which may be the consequence of the loss of balance between these two responses. Indeed, autoinflammation and autoimmunity represent the two extremes of a continuous spectrum of pathologic conditions with numerous overlaps in different pathologies. A common characteristic of these dysregulations is represented by hyperinflammation, which is an exaggerated response of the immune system, especially involving white blood cells, macrophages, and inflammasome activation with the hyperproduction of cytokines in response to various triggering stimuli. Moreover, hyperinflammation is of great interest, as it is one of the main manifestations of COVID-19 infection, and the cytokine storm and its most important components are the targets of the pharmacological treatments used to combat COVID-19 damage. In this context, the purpose of our review is to provide a focus on the pathogenesis of autoinflammation and, in particular, of hyperinflammation in order to generate insights for the identification of new therapeutic targets and strategies.

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“…There was no obvious understanding of the mechanism behind this relationship. 26 , 27 , 28 , 29 , 30 As a consequence of the similarity of the clinical presentation between the two diseases and the possible correlation between the reduction of COVID-19 disease mortality rate in influenza vaccinated patients, the rational of the importance of increasing the coverage rate of influenza vaccine has been emerged. [ 26 , 30 ] Increasing the rate of influenza vaccine uptake could decrease the burden on health care facilities associated with seasonal influenza infections, and could help to decrease COVID-19 mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Perception, knowledge and attitude towards influenza vaccine during COVID-19 pandemic in Jordanian population

Zalloum

Elayeh

Ali

et al. 2022

European Journal of Integrative Medicine

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Introduction Seasonal influenza is considered as one of the major causes of morbidity and mortality worldwide. This needs solutions to decrease burdens on the healthcare systems especially during the Coronavirus Disease (COVID-19) pandemic. Population knowledge, perception and attitude towards influenza vaccine during COVID-19 pandemic could have a positive impact to decrease mortality, morbidity and burdens on the healthcare system. This study focuses on investigating knowledge, attitude and practice (KAP) of Jordanian adults towards influenza vaccine during COVID-19 pandemic Methods This cross-sectional study recruited 1112 randomly selected Jordanian adults. A four-section questionnaire was designed and included questions about the demographic and clinical characteristics, perception about influenza, attitudes towards the role of influenza vaccine during COVID-19 pandemic and the factors that affect respondents’ practice towards influenza vaccine. Results 73.1% population were not vaccinated, and most of them were not willing to be vaccinated during COVID-19 pandemic. 55% of the population thought that influenza vaccine decreases the burdens on Jordanian healthcare system. Major refusal factor to be vaccinated was not considering influenza a threat (41.3%). People mostly got their information about influenza vaccine form the social media (64.3%) and there was neglected role of the pharmacist and physician. Conclusions The reinforcement of the role of pharmacists, physician and media to educate people about importance of influenza vaccine during COVID-19 is needed. Furthermore, campaigns should be conducted to increase the population awareness towards influenza vaccine uptake and its importance.

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Effect of influenza vaccine on COVID-19 mortality: a retrospective study

Cited by 73 publications

References 26 publications

Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study

Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized, Double-Blind, Placebo-Controlled Study

Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative Immunity

Perception, knowledge and attitude towards influenza vaccine during COVID-19 pandemic in Jordanian population

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