When performing the injection molding process, the influence of the set parameters such as injection time, injection pressure, and other parameters used will affect the mold result. The problem that arises when doing injection molding using multi-cavity molds is the appearance of product defects. The purpose of this study focuses on finding the parameters of the injection temperature, injection pressure, injection time and optimal interactions, and the position of the cavity orientation so that the product produced from multi-cavity molds is minimally flawed. The method used is to conduct experiments on the plastic molding process and compare the results of the different cavity positions in the vertical and horizontal positions. Experimental design chosen is DOE Factorial. The results obtained that there is an influence of injection temperature, injection pressure, injection time and cavity position on the number of defects. The recommended cavity position is to adjust the horizontal position right -left, because it produces minimal product defects. The smallest chance of defects occurs when the interaction of injection temperature is 210 C, injection pressure is 42 Bar, and injection time is 4.5 seconds.