Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Wang, Lu; Bi, Jianqiang; Sun, Kangning; Li, Aimin; Mao, Junjie; Yuan, Zhen; Yang, Fan

doi:10.1039/d2ce01078j

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Previous study confirmed that the polyethylene glycol during the preparation process possessed a dose-dependent effect on the thermally induced crystallization and phase evolution of ACP . Our previous study also proved that the introduction of inositol would postpone the crystallization of ACP and altered the thermodynamic equilibrium between α/β-TCP under higher temperature in a content-dependent manner . Element substitution provided a feasible path for the multifunctionalization of traditional biomaterials and related research studies were widely carried out.…”

Section: Introductionsupporting

confidence: 70%

“…Especially, the initial crystalline phase was α/β polymorphs rather than pure α polymorph. Such inconsistence came from the inherent amorphous nature of ACP and was related to the way ACP was synthesized . However, such difference was not the main subject, and the temperature-dependent XRD patterns of sample ACPs were provided for comparison.…”

Section: Resultsmentioning

confidence: 99%

“… 7 Our previous study also proved that the introduction of inositol would postpone the crystallization of ACP and altered the thermodynamic equilibrium between α/β-TCP under higher temperature in a content-dependent manner. 8 Element substitution provided a feasible path for the multifunctionalization of traditional biomaterials and related research studies were widely carried out. The perspective research based on the theoretical calculations also proved the thermodynamic stability of substitutional divalent cations in TCP.…”

Section: Introductionmentioning

confidence: 99%

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Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

Wang

Yang

et al. 2023

ACS Omega

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The presented study evaluated the effect of cosubstitution of larger and smaller divalent cations on the thermally induced crystallization of amorphous calcium phosphate (ACP). The predesigned combinations of larger (Sr 2+ and Ba 2+ ) and smaller (Mg 2+ , Cu 2+ , and Co 2+ ) divalent cations were carried out and their effects on the thermodynamic equilibrium between α/βtricalcium phosphate (TCP) were outlined. The coexistence of larger and smaller divalent cations shielded the formation of α-TCP and shifted the thermodynamic equilibrium toward the β-TCP, which implied that the smaller cations dominated the crystalline phase. However, the retarded crystallization induced by the larger cations still remained and allowed ACP to maintain its amorphous nature partly or completely until a higher temperature.

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Section: Introductionsupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%