Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

El‐Bouhy, Zeinab M.; El-Nobi, Gamal; Reda, Rasha M.; Ibrahim, Rowida E.

doi:10.21608/zvjz.2016.7872

Cited by 17 publications

(6 citation statements)

References 16 publications

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“…The elevation of mortality rate may be due to toxic effect of chlorpyrifos. Similar results were recorded by El-Bouhy et al [25] who reported that Nile tilapia showed fin rot, rapid movement of operculum with opened mouth and collection of fish near water surface when exposed to chlorpyrifos insecticide.…”

Section: Chronic Exposure Assay and Clinical Observationssupporting

confidence: 89%

Chronic Effect of Chlorpyrifos on Biochemical, Immunological Changes and DNA Damage in Juvenile Nile Tilapia (Oreochromis niloticus)

El‐Bouhy

Elhakim

Mohamed

2018

Zagazig Veterinary Journal

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Tremendous use of organophosphate insecticides especially chlorpyrifos have led to elevation of the residual levels of these insecticides in aquatic system via contaminated runoff and atmospheric deposition. Our study was done to detect the effect of different chronic concentrations of chlorpyrifos (/ 10 and 1 / 20 of 96 h LC 50) on fingerlings Nile tilapia, Oreochromis niloticus, after 8 weeks of exposure through determine the oxidative potential indices, immunological parameters and hepatic and renal markers in serum. DNA damage was determined by single-cell gel electrophoresis (Comet assay). The marked change in clinical signs and postmortem findings were recorded in chlorpyrifos exposed groups. The results showed significant increase in malondialdehyde (MDA) levels, decline in antioxidant parameters which represented by decreasing in Glutathione (GSH) activity, inhibition in immunological parameters which represented by decrease in lysozyme and nitric oxide levels in the groups that were exposed to 1 / 10 and 1 / 20 of 96 h LC 50 of chlorpyrifos. The significant elevation in hepatic and renal markers which represented by increasing in Alanine transaminase (ALT) and creatinine activities and a marked elevation DNA damage were recorded in the groups that were exposed to 1 / 10 and 1 / 20 of 96 h LC 50 of chlorpyrifos. We conclude from our study that chronic exposure of juvenile O. niloticus to chlorpyrifos has the potential to cause harmful effect.

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Section: Chronic Exposure Assay and Clinical Observationssupporting

confidence: 89%

Chronic Effect of Chlorpyrifos on Biochemical, Immunological Changes and DNA Damage in Juvenile Nile Tilapia (Oreochromis niloticus)

El‐Bouhy

Elhakim

Mohamed

2018

Zagazig Veterinary Journal

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“…In the present study, significant elevations in relative expression of interleukin 1 beta (IL-1β) gene were recorded in liver, muscle and brain of treated group compared to control. Up-regulation of interleukin-1β was previously reported in Nile tilapia intoxicated with chlorpyrifos (El-Bouhy, El-Nobi, Reda, & Ibrahim, 2016) and in zebrafish by cisbifenthrin (Jin, Pan, Cao, Ma, & Fu, 2013). Cyclooxygenase 2 (COX-2), induced by proinflammatory stimuli, cytokines, hormones and growth factors, is an important source of prostaglandin formation in inflammation (Cryer & Feldman, 1998).…”

Section: Expression Findings Of Il-1β and Cox-2 Genesmentioning

confidence: 92%

Buprofezin toxication implicates health hazards in Nile tilapia ( Oreochromis niloticus )

et al. 2020

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Insecticides are used to destroy insect pests in the agro fields to increase crop productivity. Despite the regulatory restrictions, their use gradually increases because of their broad spectrum and low cost. The high levels of insecticides present in the runoff from agricultural and industrial sources flow into the water leading to the pollution of aquatic life and health hazards in non-target organisms including fish (Prusty et al., 2015). As many traditional insecticides have been banned due to environmental and health risks, compounds with low toxicity are introduced into market. The use of insect growth regulators (IGR) as insecticides is increasing as they have a selective mode of action that differs from that of broad-spectrum neurotoxic traditional insecticides. Many insect growth regulators have superior efficiency against several insect species (Zhang, Zhao, Wang, Mu, & Liu, 2017). Insecticides affecting insect chitin growth are a promising type of IGR because of their selective mechanism of action on insects and their lower toxicity to other species. However, these insecticides have harmful effects at sublethal concentrations on non-target species. Triflumuron induced oxidative stress in the liver and kidney of Balb/C mice (Timoumi et al., 2018) while diflubenzuron and flucycloxuron affected both glutathione S-transferase activity and glutathione in adult Gambusia affinis fish (Zaidi & Soltani, 2011). Buprofezin (2-tert-butylimino-3-isopropyl-5-phenyl-1,3,5-thiadiazinan-4-one) is a thiadiazine insect growth regulator affecting chitin

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“…In line with this, malathion has a negative effect on the innate immune response (WBC, ROS production, and phagocytic activity) in C. carpio carpio [ 75 ]. Additionally, acute and chronic exposure to chlorpyrifos effects leukocyte phagocytic capacity [ 76 , 77 , 78 ]. Furthermore, malathion reduces the phagocytic capacity of Murray codfish ( Maccullochella peelii T. L. Mitchell) [ 79 ].…”

Section: Op-mediated Modulation Of the Immune Responsementioning

confidence: 99%

Organophosphate-Pesticide-Mediated Immune Response Modulation in Invertebrates and Vertebrates

Bernal-González

Covantes-Rosales

Camacho-Pérez

et al. 2023

IJMS

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Organophosphate pesticides (OPs) have greatly facilitated food production worldwide, and their use is not limited to agriculture and the control of pests and disease vectors. However, these substances can directly affect the immune response of non-target organisms. In this sense, exposure to OPs can have negative effects on innate and adaptive immunity, promoting deregulation in humoral and cellular processes such as phagocytosis, cytokine expression, antibody production, cell proliferation, and differentiation, which are crucial mechanisms for host defense against external agents. This review focuses on the scientific evidence of exposure to OPs and their toxic effects on the immune system of non-target organisms (invertebrates and vertebrates) from a descriptive perspective of the immuno-toxic mechanisms associated with susceptibility to the development of bacterial, viral, and fungal infectious diseases. During the exhaustive review, we found that there is an important gap in the study of non-target organisms, examples of which are echinoderms and chondrichthyans. It is therefore important to increase the number of studies on other species directly or indirectly affected by Ops, to assess the degree of impact at the individual level and how this affects higher levels, such as populations and ecosystems.

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Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

Cited by 17 publications

References 16 publications

Chronic Effect of Chlorpyrifos on Biochemical, Immunological Changes and DNA Damage in Juvenile Nile Tilapia (Oreochromis niloticus)

Chronic Effect of Chlorpyrifos on Biochemical, Immunological Changes and DNA Damage in Juvenile Nile Tilapia (Oreochromis niloticus)

Buprofezin toxication implicates health hazards in Nile tilapia ( Oreochromis niloticus )

Organophosphate-Pesticide-Mediated Immune Response Modulation in Invertebrates and Vertebrates

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