Effect of interpolymer complex formation between chondroitin sulfate and chitosan-gelatin hydrogel on physico-chemical and rheological properties

Ponsubha, S.; Jaiswal, Akhilesh

doi:10.1016/j.carbpol.2020.116179

Cited by 32 publications

(19 citation statements)

References 52 publications

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“…The gelatin-chitosan blends led to a slight modification of the spectrum, i.e., a shift of both carbonyls (from 1634 to 1642 cm −1 ) and amino bands (from 1561 to 1573 cm −1 ). The peak shifts in the spectrum of the CS-Gel mixture indicate the formation of a hydrogen bond between chitosan and gelatin, which is supported by other reported results [ 69 ].…”

Section: Resultssupporting

confidence: 89%

Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings

Węgrzynowska-Drzymalska

Mlynarczyk

Chełminiak-Dudkiewicz

et al. 2022

IJMS

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In this study, thin chitosan-gelatin biofilms cross-linked with dialdehyde cellulose nanocrystals for dressing materials were received. Two types of dialdehyde cellulose nanocrystals from fiber (DNCL) and microcrystalline cellulose (DAMC) were obtained by periodate oxidation. An ATR-FTIR analysis confirmed the selective oxidation of cellulose nanocrystals with the creation of a carbonyl group at 1724 cm−1. A higher degree of cross-linking was obtained in chitosan-gelatin biofilms with DNCL than with DAMC. An increasing amount of added cross-linkers resulted in a decrease in the apparent density value. The chitosan-gelatin biofilms cross-linked with DNCL exhibited a higher value of roughness parameters and antioxidant activity compared with materials cross-linked with DAMC. The cross-linking process improved the oxygen permeability and anti-inflammatory properties of both measurement series. Two samples cross-linked with DNCL achieved an ideal water vapor transition rate for wound dressings, CS-Gel with 10% and 15% addition of DNCL—8.60 and 9.60 mg/cm2/h, respectively. The swelling ability and interaction with human serum albumin (HSA) were improved for biofilms cross-linked with DAMC and DNCL. Significantly, the films cross-linked with DAMC were characterized by lower toxicity. These results confirmed that chitosan-gelatin biofilms cross-linked with DNCL and DAMC had improved properties for possible use in wound dressings.

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Section: Resultssupporting

confidence: 89%

Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings

Węgrzynowska-Drzymalska

Mlynarczyk

Chełminiak-Dudkiewicz

et al. 2022

IJMS

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“…Mechanical compression testing was performed on the hydrogel scaffolds on the basis of ASTM standard F2900-11 using a universal testing machine (Mark-10 ESM303). , Uniaxial compression force was applied on cylindrical shaped scaffolds (7 mm diameter × 5 mm height) at room temperature, through a 1.5 kN load cell at a cross head speed of 2 mm min –1 . Prior to measurement, the samples were submerged in PBS at 37 °C to reach equilibrium water uptake.…”

Section: Methodsmentioning

confidence: 99%

Nitric Oxide-Releasing Gelatin Methacryloyl/Silk Fibroin Interpenetrating Polymer Network Hydrogels for Tissue Engineering Applications

Ghalei

Douglass

Handa

2021

ACS Biomater. Sci. Eng.

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Bacterial infection is one of the principal reasons for the failure of tissue engineering scaffolds. Therefore, the development of multifunctional scaffolds that not only are able to guide tissue regeneration but also can inhibit bacterial colonization is of great importance for tissue engineering applications. In this study, a highly antibacterial, biocompatible, and biodegradable scaffold based on silk fibroin (SF) and gelatin methacryloyl (GelMA) was prepared. Sequential cross-linking of GelMA and SF under UV irradiation and methanol treatment, respectively, resulted in the formation of interpenetrating network (IPN) hydrogels with a porous structure. In addition, impregnation of the hydrogels with a nitric oxide (NO) donor molecule, S-nitroso-N-acetylpenicillamine (SNAP), led to the development of NO-releasing scaffolds with strong antibacterial properties. According to the obtained results, the addition of SF to GelMA hydrogels caused an enhancement in the mechanical properties and NO release kinetics and prevented their rapid enzymatic degradation in aqueous media. Furthermore, swelling the GelMA-SF scaffolds with SNAP resulted in a bacteria reduction efficiency of >99.9% against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The scaffolds also showed great cytocompatibility in vitro by increasing the proliferation and supporting the adhesion of 3T3 mouse fibroblast cells. Overall, GelMA-SF-SNAP showed great promise to be used as a scaffold for tissue engineering and wound healing applications.

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“…Its characteristics include good biocompatibility, appropriate mechanical properties, flexibility, non-reactiveness with host tissues, the ability to absorb more wound exudates, and high water retention capacity. The property of water retention capacity helps to reduce the temperature and soothing the wound vicinity which prevents the formation of scabs [87][88][89]. As well, hydrogel allows fast wound healing by involving all four stages of the wound curative process known as hemostasis, inflammation, cell migration/proliferation and maturation [90].…”

Section: Self-healing Hydrogels In Wound Healingmentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

Self Cite

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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Effect of interpolymer complex formation between chondroitin sulfate and chitosan-gelatin hydrogel on physico-chemical and rheological properties

Cited by 32 publications

References 52 publications

Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings

Chitosan-Gelatin Films Cross-Linked with Dialdehyde Cellulose Nanocrystals as Potential Materials for Wound Dressings

Nitric Oxide-Releasing Gelatin Methacryloyl/Silk Fibroin Interpenetrating Polymer Network Hydrogels for Tissue Engineering Applications

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

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