Effect of intrathecal and intravenous administration of oxytocin on amplitude of the reflex-evoked muscle action potential after electrical stimulation of the tooth pulp in anesthetized dogs

Abstract

Although IV administration of oxytocin did not have an effect on REMP amplitude, compared with IV administration of saline solution, IT administration of oxytocin had the opposite effect of morphine and increased REMP amplitude of the digastricus muscle. These data do not support the use of oxytocin as an analgesic agent in dogs.

Quantitative assessment of nociceptive processes in conscious dogs by use of the nociceptive withdrawal reflex

“…Unlike cats (for which there is extensive literature), dogs are seldom used as experimental animals in nociception studies. There are some experimental and clinical studies in dogs in which mechanical, [3][4][5] thermal, 4,6,7 and electrical 5,[8][9][10][11] stimulations have been applied to evoke nocifensive reactions and evaluate their pharmacologic modulation. The end point of these models of acute nociception in dogs is determined by monitoring the evoked gross behavioral reaction 1,12,13 or the thresholds [3][4][5]8 at which the behavioral aversive response is elicited.…”

Use of noninvasive dental dolorimetry to evaluate analgesic effects of intravenous and intrathecal administration of morphine in anesthetized dogs

“…39 Mean (± SD) end-tidal concentration of isoflurane needed to maintain all dogs at a light plane of anesthesia was 1.3 ± 0.09%. 39 Mean (± SD) end-tidal concentration of isoflurane needed to maintain all dogs at a light plane of anesthesia was 1.3 ± 0.09%.…”

Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

“…Analgesic effects of OXY have been demonstrated in multiple non-human species including rodents, dogs [108,109], cats [110], and rabbits [111]. OXY administered systemically or at CNS sites such as the spinal intrathecal space [112], PAG [53,54], caudate nucleus [113], nucleus accumbens [114] and amygdala [115] produces analgesia in rodents.…”

“…OXY administered systemically or at CNS sites such as the spinal intrathecal space [112], PAG [53,54], caudate nucleus [113], nucleus accumbens [114] and amygdala [115] produces analgesia in rodents. Specifically, studies examining the effects of OXY administration have shown rats to be less sensitive to electrical, thermal, chemical and mechanical pain stimuli [49, 116–125], and to also have less pain following acute stress [75], acute inflammation [50,112,126–129], tooth pulp stimulation [108, 109, 130] and neuropathic injury [131,132]. In most cases, this analgesia was reversed with OXTR antagonists.…”