Effect of intratracheal instillation of ultrafine carbon black on proinflammatory cytokine and chemokine release and mRNA expression in lung and lymph nodes of mice

Shwe, Tin Tin Win; Yamamoto, Shoji; Kakeyama, Masaki; Kobayashi, Takuro; Fujimaki, Hidekazu

doi:10.1016/j.taap.2005.03.014

Cited by 58 publications

(16 citation statements)

References 38 publications

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“…Intranasal instillation is not a realistic exposure route compared with inhalation exposure; however, it is a simple and appropriate way to study the effects of exposure to chemical substances through the airway. The total dose of carbon black nanoparticle in this study was 2 mg/kg, which was lower than the dose used in many earlier studies (Chen et al, 2009;Fedulov et al, 2008;Tin-Tin-Win-Shwe et al, 2005Takeda et al, 2009;Shimizu et al, 2009;Takahashi et al, 2010) but a little higher than that (1.6 mg/kg) used by Elderly et al, (2009). Further investigation using aerosol exposure and dose-response analysis is required to understand the effect of maternal exposure to nanoparticles.…”

Section: Discussioncontrasting

confidence: 59%

“…It is well known that the core of combustion-derived particles is composed of carbon nanoparticles (BéruBé et al, 2007), which represent relevant surrogates for exhaust particles from modern diesel engines . Earlier studies showed that exposure to ultrafine carbon black through the airway affects the respiratory system (Donaldson et al, 2005;Tin-Tin-Win-Shwe et al, 2005;Erdely et al, 2009), the cardiovascular system (Donaldson et al, 2005;Erdely et al, 2009), the central nervous system (Donaldson et al, 2005;Tin-Tin-Win-Shwe et al, 2006) and other organs (Donaldson et al, 2005). However, it is not known how carbon black nanoparticle affects the fetus in utero and future offspring.…”

Section: Introductionmentioning

confidence: 99%

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Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring

et al. 2011

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-The potential health risks of inhaling nanomaterials are of great concern because of their high specific activity and their unique property of translocation. Earlier studies showed that exposure to nanoparticles through the airway affects both respiratory and extrapulmonary organs. When pregnant mice were exposed to nanoparticles, the respiratory system, the central nervous system and the reproductive system of their offspring were affected. The aim of this study was to assess the effect of maternal exposure to nanoparticles on the offspring, particularly on the kidney. Pregnant ICR mice were exposed to a total of 100 μg of carbon black nanoparticle on the fifth and the ninth days of pregnancy. Samples of blood and kidney tissue were collected from 3-week-old and 12-week-old male offspring mice. Collagen expression was examined by quantitative RT-PCR and immunohistochemistry. Serum levels of creatinine and blood urea nitrogen were examined. Exposure of pregnant ICR mice to carbon black resulted in increased expression of Collagen, type VIII, a1 (Col8a1) in the tubular cells in the kidney of 12-week-old offspring mice but not in 3-week-old ones. The levels of serum creatinine and blood urea nitrogen, indices of renal function, were not different between the groups. These observations were similar to those of tubulointerstitial fibrosis in diabetic nephropathy. These results suggest that maternal exposure to carbon black nanoparticle induces renal abnormalities similar to tubulointerstitial fibrosis in diabetic nephropathy are induced in the kidney of offspring.

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring

et al. 2011

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“…We have speculated that the time lag and complex interplay among incoming C-fiber stimulation, reactive oxygen species (ROS) production (Adler et al 1999; Avshalumov et al 2000; Girouard and de Champlain 2005; Zanzinger and Czachurski 2000), and inflammation with proinflammatory cytokines release (Elder et al 2004; Hirano et al 1994; Kang et al 2002; Lei et al 2004a, 2004b, 2005; Shwe et al 2005; Tracey 2002; Yang et al 1997) might all contribute to the synthesis of the observed biphasic responses. However, this speculation warrants further testing and verification.…”

Section: Discussionmentioning

confidence: 99%

Interaction Effects of Ultrafine Carbon Black with Iron and Nickel on Heart Rate Variability in Spontaneously Hypertensive Rats

Chang

Hwang

Chan

et al. 2007

Environ Health Perspect

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BackgroundParticulate matter (PM) has been reported to be associated with alterations in heart rate variability (HRV); however, the results are inconsistent. We propose that different components of PM cause the discrepancy.ObjectiveIn this study, our goal was to determine whether different types of exposure would cause different HRV effects, and to verify the interactions between co-exposing components.MethodsUltrafine carbon black (ufCB; 14 nm; 415 μg and 830 μg), ferric sulfate [Fe2(SO4)3; 105 μg and 210 μg], nickel sulfate (NiSO4; 263 μg and 526 μg), and a combination of high-dose ufCB and low-dose Fe2(SO4)3 or NiSO4 were intratracheally instilled into spontaneously hypertensive rats. Radiotelemetry data were collected in rats for 72 hr at baseline and for 72 hr the following week to determine the response to exposure. Effects of exposure on 5-min average of normal-to-normal intervals (ANN), natural logarithm-transformed standard deviation of the normal-to-normal intervals (LnSDNN), and root mean square of successive differences of adjacent normal-to-normal intervals (LnRMSSD) were analyzed using self-control experimental designs.ResultsBoth high- and low-dose ufCB decreased ANN marginally around hour 30, with concurrent increases of LnSDNN. LnRMSSD returned to baseline levels after small initial increases. We observed minor effects after low-dose Fe and Ni instillation, whereas biphasic changes were noted after high-dose instillations. Combined exposures of ufCB and either Fe or Ni resulted in HRV trends different from values estimated from individual-component effects.ConclusionsComponents in PM may induce different cardioregulatory responses, and a single component may induce different responses during different phases. Concurrent exposure to ufCB and Fe or Ni might introduce interactions on cardioregulatory effects. Also, the effect of PM may be mediated through complex interaction between different components of PM.

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“…The data are in concordance with results from previous studies on repeated i.t. instillation of Printex 90 to Balb/c mice [45]. It has also been shown that multiple i.t.…”

Section: Discussionmentioning

confidence: 99%

Inflammation and Vascular Effects after Repeated Intratracheal Instillations of Carbon Black and Lipopolysaccharide

et al. 2016

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Inflammation and oxidative stress are considered the main drivers of vasomotor dysfunction and progression of atherosclerosis after inhalation of particulate matter. In addition, new studies have shown that particle exposure can induce the level of bioactive mediators in serum, driving vascular- and systemic toxicity. We aimed to investigate if pulmonary inflammation would accelerate nanoparticle-induced atherosclerotic plaque progression in Apolipoprotein E knockout (ApoE-/-) mice. ApoE -/- mice were exposed to vehicle, 8.53 or 25.6 μg nanosized carbon black (CB) alone or spiked with LPS (0.2 μg/mouse/exposure; once a week for 10 weeks). Inflammation was determined by counting cells in bronchoalveolar lavage fluid. Serum Amyloid A3 (Saa3) expression and glutathione status were determined in lung tissue. Plaque progression was assessed in the aorta and the brachiocephalic artery. The effect of vasoactive mediators in plasma of exposed ApoE-/- mice was assessed in aorta rings isolated from naïve C57BL/6 mice. Pulmonary exposure to CB and/or LPS resulted in pulmonary inflammation with a robust influx of neutrophils. The CB exposure did not promote plaque progression in aorta or BCA. Incubation with 0.5% plasma extracted from CB-exposed ApoE-/- mice caused vasoconstriction in aorta rings isolated from naïve mice; this effect was abolished by the treatment with the serotonin receptor antagonist Ketanserin. In conclusion, repeated pulmonary exposure to nanosized CB and LPS caused lung inflammation without progression of atherosclerosis in ApoE-/- mice. Nevertheless, plasma extracted from mice exposed to nanosized CB induced vasoconstriction in aortas of naïve wild-type mice, an effect possibly related to increased plasma serotonin.

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Effect of intratracheal instillation of ultrafine carbon black on proinflammatory cytokine and chemokine release and mRNA expression in lung and lymph nodes of mice

Cited by 58 publications

References 38 publications

Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring

Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring

Interaction Effects of Ultrafine Carbon Black with Iron and Nickel on Heart Rate Variability in Spontaneously Hypertensive Rats

Inflammation and Vascular Effects after Repeated Intratracheal Instillations of Carbon Black and Lipopolysaccharide

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