Effect of intrauterine administration of ceftiofur on fertility and risk of culling in postparturient cows with retained fetal membranes, twins, or both

Scott, H. M.; Schouten, M.J.; Gaiser, Jeffrey C.; Belschner, A.P.; Jordan, Ellen R.

doi:10.2460/javma.2005.226.2044

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Routine systemic or intra-uterine administration of ceftiofur may be beneficial for the prevention of clinical metritis, however its effect on reproductive performance is not significantly different to that of no treatment therefore it cannot be recommended for the field [6,49,51,90]. Similarly controversial results were reported when a single-dose of ceftiofur crystalline free acid sterile suspension was used in dairy cows at high risk of uterine disease (twin, dystocia, or retained placenta) within 24 hr after calving [28,29].…”

Section: Prevention Of Uterine Diseasesmentioning

confidence: 99%

Recent Possibilities for Diagnosis and Treatment of Post Parturient Uterine Diseases in Dairy Cow

Szenci¹

2016

JFIV Reprod Med Genet

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Clinical metritis is an acute systemic illness due to infection of the uterus with bacteria, usually within 10 (21) days after parturition. According to Sheldon et al. [5], clinical metritis can be categorized into three grades: Grade 1 clinical metritis (CM1) can be characterized by an abnormally enlarged uterus and a purulent uterine discharge detectable in the vagina, within 21 days after calving. Grade 2 clinical metritis (CM2) or puerperal metritis can be characterized by a fetid red-brown watery uterine discharge, atonic enlarged uterus and, usually pyrexia (>39.5°C) [6,7]; in severe cases, reduced milk yield, dullness, inappetence or anorexia, elevated heart rate, and apparent dehydration may also be present. In some cases pyrexia even with daily monitoring of rectal temperature could not be detected [4,8] however an enlarged uterus with a thin wall and atonia used to be present with a fetid discharge. Puerperal metritis is often associated with retained placenta, dystocia, stillbirth or twins, and usually occurs toward the end of the first week after calving, being rare after the second week after calving [7,9,10]. It is important to emphasize

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Section: Prevention Of Uterine Diseasesmentioning

confidence: 99%

Recent Possibilities for Diagnosis and Treatment of Post Parturient Uterine Diseases in Dairy Cow

Szenci¹

2016

JFIV Reprod Med Genet

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“…Ceftiofur has been used solely to treat certain respiratory diseases in bovine beef animals as well as dairy cattle, interdigital dermatitis in bovine animals and other animals (Salmon et al, 1995).This antimicrobial is also used exclusively for the treatment of mastitis and septic circumstances in livestock (Erskine et al, 1995 andStanek andKofler 1998).Ceftiofur may also treat intrauterine infections that cause metritis, retained placenta (Scott et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Studies Of Ceftiofur (Ceftiprima In Calves)

Talaat

Attia

El-Hewaity

2019

Journal of Current Veterinary Research

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The kinetic profile of ceftiofur in calves was studied after single intramuscular and intravenous administrations at a dose of 2.2 mg ceftiofur/kg b.wt. Serum concentrations of ceftiofur were determined by using high performance liquid chromatography (HPLC). Following compartmental analysis, a two-compartment open model best described the concentration-time data of ceftiofur after i.m. and i.v. administration. After intramuscular administration, the drug reached its maximum serum concentrations (Cmax) of 6.51 ± 0.123 μg/ml at maximum time (Tmax) of 2.49 ± 0.073 h,absorption half-life (t1/2ab) was 0.57 ± 0.035 h and (AUC0-t) was 100. 8 ± 0.69 μg/ml.h.Following a single intravenous injection, the drug was detected till 24 hours, distribution half-life (t1/2α) was 0.11 ± 0.01 h, elimination half-life (t1/2β) was of 11.07 ± 0.12 h and clearance (CL) was 0.013 ± 0.005 (L/kg/h), volume of distribution at steady state (Vdss) was 0.16 ± 0.004 (L/kg) and bioavailability was 64.66±0.39%.

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Reproductive Diseases

Gilbert¹

2018

Rebhun's Diseases of Dairy Cattle

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Effect of intrauterine administration of ceftiofur on fertility and risk of culling in postparturient cows with retained fetal membranes, twins, or both

Cited by 6 publications

References 17 publications

Recent Possibilities for Diagnosis and Treatment of Post Parturient Uterine Diseases in Dairy Cow

Recent Possibilities for Diagnosis and Treatment of Post Parturient Uterine Diseases in Dairy Cow

Pharmacokinetic Studies Of Ceftiofur (Ceftiprima In Calves)

Reproductive Diseases

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