Effect of intravenous dexmedetomidine (1 and micro;g/kg) in obtunding the pressor response to laryngoscopy and tracheal intubation compared to intravenous preservative free 2% lignocaine (1.5mg/kg)

Abstract

Background: Haemodynamic variation during layngoscopy/intubation is always a matter of concern for Anesthesiologists. A stable circulatory system is the wish of all performing general anaesthesia. Hence an acceptable and easy method needs to be established to prevent the haemodynamic variations. Our aim was to evaluate the effect of intravenous Dexmedetomidine (1µg/kg) infusion in obtunding the pressor response to laryngoscopy and tracheal intubation compared to intravenous preservative free 2% Lignocaine (1.5mg/kg). Methods: In this study, 60 patients, aged between 18-60 years belonging to ASA I and II are included. They were randomly divided into 2 groups, each comprising of 30. In group D, patients were given Dexmedetomidine 1µg/kg IV infusion over 10min and in group L, patient were given Lignocaine 1.5mg/kg IV. Results: In group D, the systolic, diastolic, mean arterial pressure and heart rate decreased significantly, from baseline, at first, second, third, fourth and fifth minute post intubation. In group L, the systolic, diastolic, mean arterial pressure and heart rate increased from baseline at first and second minute and then decreased at third, fourth and fifth minute post intubation. Conclusions: When compared between the two groups all the hemodynamic parameters showed statistical significance. There are no significant side effects and severe haemodynamic variability like hypotension and bradycardia. Therefore we concluded that Dexmedetomidine is superior to lignocaine in blunting the hemodynamic response to laryngoscopy and endotracheal intubation without any significant side effects.

Efficacy of Different Doses of Dexmedetomidine in Blood Pressure to Laryngoscopy in Controlled Hypertensive Patient: A Randomized Control Trial

“…e intergroup comparison revealed a statistically signi cant (p<0.05). Similar observations regarding the SBP and DBP were also Samala et al 8 , Pramanick et al 9 and Sebastian et al 6 .…”

Comparison of the Efficacy of Intravenous Lignocaine and Intravenous Dexmedetomidine in Attenuation of Hemodynamic Stress Response to Laryngoscopy and Endotracheal Intubation

“…4 Hemodynamic findings are not severe in normal patients but might be dangerous in patients with cardiovascular and central nervous system disorders. 5 Rashmi HD reported the cardiovascular response of intubation during anaesthesia. 6 Much study is being processed to avoid or at least blunt these reactions.…”

Different doses of Dexmedetomidine in attenuating the pressor response to laryngoscopy in controlled hypertensive patient under general anesthesia

“…However both laryngoscopy and intubation are noxious stimuli and are associated with stress responses and haemodynamic responses in the form of laryngo-sympathetic stimulation which is manifested as hypertension, tachycardia and arrhythmias 15 . These haemodynamic responses are well tolerated in otherwise healthy individuals, but in patients with hypertension, coronary heart these transient changes can result in potentially deleterious effects like left ventricular failure, pulmonary edema, myocardial ischemia, ventricular dysrhythmias and cerebral hemorrhage 8 .…”