Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study

Thakor, Nilesh; Bhagora, Samir; Asari, Unnati; Kharadi, Ashish; Pandor, Jyotsna; Prajapati, Dipak

doi:10.5455/ijmsph.2015.100920145

Cited by 8 publications

(13 citation statements)

References 4 publications

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“…11,13,16,20,[22][23][24][25]27,31,32,34,36,38,40,44,49 Across all studies, the median reported prevalence of ADRs was similar among prospective (4.5%) 11,16,19,20,22,23,27,29,31,32,34,36,38,40,44,49,53,[55][56][57] and retrospective (5%) 13,52,54 studies. Eighteen studies administered a test dose, 15,23,[25][26][27][28][29][30][31]34,37,…”

Section: Tolerabilitymentioning

confidence: 99%

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

Qassim

Mol

Grivell

et al. 2017

Aust NZ J Obst Gynaeco

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Background: Intravenous (IV) iron in pregnancy is useful where oral iron is not tolerated or a rapid replenishment of iron is required. Aims:To review the literature on the efficacy and safety of different IV iron preparations in the management of antenatal iron-deficiency anaemia (IDA). Materials and methods:We searched MEDLINE, Embase and Scopus from inception to June 2016. Eligible studies were randomised controlled trials (RCTs) and observational studies, involving administration of IV iron (ferric carboxymaltose (FCM), iron polymaltose (IPM) or iron sucrose (IS)), regardless of comparator, to manage antenatal IDA. Two independent reviewers selected studies, extracted data and assessed quality.

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Section: Tolerabilitymentioning

confidence: 99%

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

Qassim

Mol

Grivell

et al. 2017

Aust NZ J Obst Gynaeco

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“…percent in developing countries and 65-75 percent in India. 3 Prevalence of anemia in adolescent girls, pregnant women and in lactating mother is higher in India as compared to other developing countries. As per National Family Health Survey-4 (NFHS-4) prevalence of Iron deficiency anaemia (IDA) in pregnant women is 50.3% in India and 51.3% in Gujarat.…”

Section: Introductionmentioning

confidence: 99%

Impact of educational intervention regarding anaemia and its preventive measures among pregnant women: an interventional study

Nimbalkar

Patel

Thakor

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy and major contributory factor to maternal morbidity and mortality. Objective of present study was to assess knowledge of pregnant women regarding anaemia and its preventive measures before and after educational interventional training.Methods: The present study was an interventional study undertaken in purposively selected pregnant women attending the out patient Department of Obstetrics and Gynecology Department of GMERS Medical College, Gandhinagar During the month of October 2017. Total 100 pregnant women were included after written informed consent. Baseline knowledge of pregnant women regarding anaemia and its preventive measures was assessed by pre-designed, pre-tested and semi structured questionnaire. Single educational interventional training for 45 minutes was given to selected pregnant women. Post– intervention knowledge of pregnant women for the same was assessed after training. Thus, collected data was analyzed /using Epi info 7.Results: Baseline knowledge of the pregnant women regarding causes, signs and symptoms of anemia and dietary sources of iron was 21%, 23% and 40% respectively which was significantly increased to 64%, 66% and 72% respectively after the intervention. Baseline knowledge of the pregnant women regarding factors which inhibit and increase iron absorption was 25% and 4% respectively which was significantly increased to 55% and 41 % respectively after the intervention. Baseline knowledge of the pregnant women regarding treatment of anaemia was 30% which was significantly increased to 79 % after the intervention.Conclusions: There was significant improvement in the knowledge regarding anaemia and its preventive measures among pregnant women after our single educational session.

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“…p value of less than 0.5 was considered to be significant. 3 The data was compiled and standard tests of significance (p-value) were applied.…”

Section: Methodsmentioning

confidence: 99%

“…WHO has estimated prevalence of anemia in developed and developing countries in pregnant women are 14 percent in developed and 51 percent in developing countries and 65-75 percent in India. 3 Prevalence of anemia in all groups is higher in India as compared to other developing countries. As per National Family Health Survey-4 (NFHS-4) prevalence of Iron deficiency anaemia (IDA) in pregnant women is 50.3% in India and 51.3% in Gujarat.…”

Section: Introductionmentioning

confidence: 96%

“…Iron sucrose complex (ISC) is a relatively new drug, which is used intravenously for the correction of IDA. 3 The drug has been able to raise the Hb to satisfactory level when used in severely anemic iron deficient pregnant women. 6,7 Recent evidence suggests that iron sucrose can be detected in high levels in liver circulation and marrow within 5 min after intravenous administration.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of intravenous iron sucrose therapy for management of moderate to severe anaemia in pregnancy

Nimbalkar¹,

Patel²,

Thakor³

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy and major contributory factor to maternal morbidity and mortality. Objective of present study was to evaluate the response and effectof parenteral iron sucrose complex therapy in iron deficiency anemia in pregnancy.Methods: A prospective observational study was conducted at GMERS Medical College, Dharpur-Patan over a period extending from September 2014 to August 2017. A total of 150 Antenatal women, between 26-32 weeks of pregnancy with hemoglobin between 5-9 gm% were selected for study by purposive sampling. They were given intravenous iron sucrose complex in a dose of 200 mg (2 ampules of 5 ml each) in 100 ml normal saline over a period of 15-20 minutes, on alternate day. Repeat CBC was done after a period of 6 weeks.Results: Age range of the patients was 20 to 34 years. Out of total 150 women, 72 women (48%) were in age group of 20-24 years. 64.6% women had 27-29 weeks of pregnancy. 58 (38.6%) women had <8 gm% of Hb before treatment and 108 (72%) women achieved Hb of 10 gm% after treatment. The mean haemoglobin raised from 7.9±0.92 gm% to 10.3±0.83 gm% (P<0.001) after six weeks of therapy. There was significant rise in MCV levels (from 67.7±5.1 fl to 78.9±6.4fl) (P<0.001). Major side effects or anaphylactic reactions were occurred in none of the women during study period. 93.3% of patients, treated for anemia were delivered at full term, either vaginally (67.3%) or by LSCS (26%). Most of the delivered babies (80%), had birth weight of more than 2.5 kgs.Conclusions: Parentral iron therapy was effective in increasing haemoglobin and other haematological parameters in pregnant women with moderate to severe anaemia.

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Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study

Cited by 8 publications

References 4 publications

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

Impact of educational intervention regarding anaemia and its preventive measures among pregnant women: an interventional study

Evaluation of intravenous iron sucrose therapy for management of moderate to severe anaemia in pregnancy

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