Effect of Intravenous ω‐3 Fatty Acid Infusion and Hemodialysis on Fatty Acid Composition of Free Fatty Acids and Phospholipids in Patients With End‐Stage Renal Disease

Madsen, Trine; Christensen, Jeppe Hagstrup; Toft, Egon; Aardestrup, Inge Valbak; Lundbye‐Christensen, Søren; Schmidt, Erik Berg

doi:10.1177/0148607110371807

Cited by 11 publications

(12 citation statements)

References 42 publications

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“…FFAs have many biological functions in individuals. High levels of FFAs and the redundant SFAs are all strongly linked to higher risk of cardiovascular disease in patients with kidney disease. Many studies , have reported that the level of FFAs and SFAs obviously rises in plasma of kidney disease patients.…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography–Mass Spectrometry

Wang

Liu

et al. 2016

J. Proteome Res.

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Chronic kidney disease (CKD) has been a global health problem that has a great possibility of being developed into uremia in the end. Hemodialysis (HD) is the most commonly used strategy for treating uremic patients; however, the patients still have a high risk of suffering various complications. It is well recognized that lipid disorder usually occurs in maintenance HD patients. To systemically study the effects of HD on lipid metabolism associated with uremia, we employed an ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS)-based lipidomics method. A total of 87 human plasma samples from patients with prehemodialysis (pre-HD)/posthemodialysis (post-HD) treatment and the healthy controls were enrolled in the study. As compared with pre-HD patients, many plasma lipids showed significant changes (p < 0.05) in patients receiving HD therapy. Specifically, sum of free fatty acids (FFA) as well as saturated FFA and eicosanoids and sums of lyso-phosphatidylinositols and lyso-phosphatidylethanolamines, FFA 16:1/FFA 16:0, and FFA 18:1/FFA 18:0 were obviously higher in the pre-HD group than in the controls while they were significantly lower in patients after HD. These results indicated that UPLC-Q-TOF/MS-based lipidomics is a promising approach to investigate lipid alterations in relation to uremia and it is helpful to understand complex complications involved in HD patients.

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Section: Discussionmentioning

confidence: 99%

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography–Mass Spectrometry

Wang

Liu

et al. 2016

J. Proteome Res.

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“…After the exclusion of 437 duplications, 1051 references were reviewed for eligibility. Then, two systematic reviews and 25 randomized clinical trials without relevant outcomes were excluded [31,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69]. There were 21 references from 18 RCTs meeting the eligibility criteria (Figure 1) [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials

Yeh

et al. 2019

IJMS

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The effects of polyunsaturated fatty acids (PUFAs) on inflammatory markers among patients receiving dialysis have been discussed for a long time, but previous syntheses made controversial conclusion because of highly conceptual heterogeneity in their synthesis. Thus, to further understanding of this topic, we comprehensively gathered relevant randomized clinical trials (RCTs) before April 2019, and two authors independently extracted data of C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) for conducting network meta-analysis. Eighteen eligible RCTs with 962 patients undergoing dialysis were included in our study. The result showed that with placebo as the reference, PUFAs was the only treatment showing significantly lower CRP (weighted mean difference (WMD): −0.37, 95% confidence interval (CI): −0.07 to −0.68), but the CRP in PUFAs group was not significantly lower than vitamin E, PUFAs plus vitamin E, or medium-chain triglyceride. Although no significant changes were noted for hs-CRP and IL-6 levels, PUFAs showed the best ranking among treatments according to surface under the cumulative ranking. Therefore, PUFAs could be a protective option for patients receiving dialysis in clinical practice.

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“…This study showed the increased levels of several saturated free fatty acids (FFA), including behenic acid, in adenine-induced rats compared with control rats. The redundant of FFA and saturated FFA are linked to higher risk of cardiovascular disease in patients with CKD [40,41]. The earlier studies have demonstrated that the levels of FFA and saturated fatty acids obviously were increased in plasma of patients with end-stage renal disease [40,42].…”

Section: Discussionmentioning

confidence: 99%

“…The redundant of FFA and saturated FFA are linked to higher risk of cardiovascular disease in patients with CKD [40,41]. The earlier studies have demonstrated that the levels of FFA and saturated fatty acids obviously were increased in plasma of patients with end-stage renal disease [40,42]. Wang et al has reported that the levels of total FFA and saturated FFA and the values of FFA(16:1)/FFA(16:0) and FFA(18:1)/FFA(18:0) were significantly increased in patients with pre-hemodialysis than in healthy controls, whereas they were significantly decreased in patients after hemodialysis [43].…”

Section: Discussionmentioning

confidence: 99%

The Dysregulation of Eicosanoids and Bile Acids Correlates with Impaired Kidney Function and Renal Fibrosis in Chronic Renal Failure

Wang

Zhang

et al. 2021

Metabolites

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Chronic renal failure (CRF) is an irreversible deterioration of the renal functions that characterized by fluid electrolyte unbalance and metabolic-endocrine dysfunctions. Increasing evidence demonstrated that metabolic disturbances, especially dyslipidemia and profound changes in lipid and lipoprotein metabolism were involved in CRF. Identification of lipids associated with impaired kidney functions may play important roles in the understanding of biochemical mechanism and CRF treatment. Ultra-performance liquid chromatography coupled with high-definition mass spectrometry-based lipidomics was performed to identify important differential lipids in adenine-induced CRF rats and investigate the undergoing anti-fibrotic mechanism of Polyporus umbellatus (PPU) and ergone (ERG). Linear correlation analysis was performed between lipid species intensities and creatinine levels in serum. Adenine-induced rats exhibited declining kidney function and renal fibrosis. Compared with control rats, a panel of lipid species was identified in the serum of CRF rats. Our further study demonstrated that eight lipids, including leukotrienes and bile acids, presented a strong linear correlation with serum creatinine levels. In addition, receiver operating characteristics analysis showed that eight lipids exhibited excellent area under the curve for differentiating CRF from control rats, with high sensitivity and specificity. The aberrant changes of clinical biochemistry data and dysregulation of eight lipids could be significantly improved by the administration of PPU and ergone. In conclusion, CRF might be associated with the disturbance of leukotriene metabolism, bile acid metabolism and lysophospholipid metabolism. The levels of eicosanoids and bile acids could be used for indicating kidney function impairment in CRF. PPU could improve renal functions and either fully or partially reversed the levels of eicosanoids and bile acids.

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Effect of Intravenous ω‐3 Fatty Acid Infusion and Hemodialysis on Fatty Acid Composition of Free Fatty Acids and Phospholipids in Patients With End‐Stage Renal Disease

Abstract: Intravenous ω-3 PUFAs administered during HD caused a transient selective increase in ω-3 FFA concentration. Furthermore, ω-3 PUFAs were rapidly incorporated into platelets, and the content of ω-3 PUFAs in plasma phospholipids increased after 48 hours.

Cited by 11 publications

References 42 publications

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography–Mass Spectrometry

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography–Mass Spectrometry

Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials

The Dysregulation of Eicosanoids and Bile Acids Correlates with Impaired Kidney Function and Renal Fibrosis in Chronic Renal Failure

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