Effect of Intravesical Prostatic Protrusion on the Characteristics of Lower Urinary Tract Symptom Change after 12‐Week Drug Medication: A Prospective Analysis

Park, Hyoung Keun; Choo, Gwoan Youb; Chung, Hong; Paick, Sung Hyun; Kim, Hyeong Gon; Kim, Hong Sup; Lho, Yong Soo; Hong, Woo Sung; Yang, Seung Boo

doi:10.1111/j.1757-5672.2012.00154.x

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…Recent research analyzed patients treated with alpha blocker and revealed that an approximate forty percent of the grade 3 IPP patients were treatment non-responders and achieved more grim outcomes than grade 1 IPP patients at the end of treatment (3 months). More recently, it is unearthed that IPP correlates with poorer treatment response thus a markedly negative association between IPP-post treatment IPSS (Park et al, 2013;Park et al, 2012). The aforementioned evidence, generated from the research and yielded by literature reviews serve to highlight the fact that alpha blocker, to a large extent, is a viable treatment option for LUTS among patients with and without IPP likewise.…”

Section: Discussionmentioning

confidence: 99%

Association of Intravesical Prostatic Protrusion Grade and the Outcome of Alpha Blocker Treatment for Bladder Outflow Obstruction

BUMBIA,

SOOMRO,

JAVED

et al. 2023

Biol Clin Sci Res J

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Benign Prostatic Hyperplasia (B.P.H) affects up to 80% of men older than 45 years of age worldwide, half of whom will eventually require treatment for its clinical manifestations such as bladder outflow obstruction (BOO) and its associated symptoms. There are various treatment strategies for B.P.H; alpha blockers being the most commonly employed. However, the outcome of said pharmacologic agent in treatment of BOO, in the presence of intra-vesical prostatic protrusion (IPP) of varying grades is less researched. The aim of the current study was to study the association IPP grade and the outcome of BOO treatment among patients with BPH. This prospective cohort comprised of a sample of 100 B.P.H patients, aged ≥ 45 years (chosen via non-probability – consecutive sampling), presenting to Ziauddin University Hospital, Karachi from June 2019 to December 2019. After taking written informed consent, data was recorded onto a pre-structured questionnaire containing inquiries pertaining to basic biodata, sociodemographic details, disease particulars, treatment outcome (gauged using IPSS, UFM and PVR) assessed at first contact and again after 1 and 3 months. The data obtained was analyzed using SPSS v. 21.0. The mean age of the sample stood at 68 years (SD ± 10.3).The mean prostate size was recorded to be 58 cm3 (SD ± 32) . The commonest grade of IPP was II (45%), followed by grade I (29%) and grade III (24%). The cumulative treatment outcome was poor, with only a meagre improvement (9.1% in IPSS score, 4% in UFM value and 13% in PVR) was recorded. Stratification revealed that the treatment outcome became progressively worse with increasing grade of IPP. After careful consideration, it can be concluded that the outcome of alpha blocker treatment for BOO among patients with IPP is poor. IPP serves to seemingly dampen the effect of alpha blockers with increasing grades corresponding to progressively worse outcome. Thus, additional modalities may be employed to supplement alphab blocker treatment for better patient outcome among patients with IPP.

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Section: Discussionmentioning

confidence: 99%

Association of Intravesical Prostatic Protrusion Grade and the Outcome of Alpha Blocker Treatment for Bladder Outflow Obstruction

BUMBIA,

SOOMRO,

JAVED

et al. 2023

Biol Clin Sci Res J

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“…These studies highlight that moderate to severe degree of IPP significantly affects BOO and influences the effectiveness of alpha receptor inhibitors in managing lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) 18 . These patients may not respond with medical treatment either α-blocker/5 α-reductase 12,19,20 mono-therapy 21 or combination therapy, [22][23][24] comparing to the patients with mild degree of IPP which the odd ratio of success of medical therapy is 59 times higher than the patients with a high grade IPP. 13,22 Patients with IPP show less improvement of storage symptoms after 12 weeks of medical treatment.…”

Section: Ipp and Bph Treatment Optionsmentioning

confidence: 99%

“…13,22 Patients with IPP show less improvement of storage symptoms after 12 weeks of medical treatment. 19 The study from Park et.al stated that men with IPP grade 3 (≥10mm) had poor response with alpha adrenoreceptor antagonists (tamsulosin) among patients with LUTS due to benign prostatic obstruction, prostatic volume <40 ml, and PSA <1.5 ng/ml. 25,26 Moreover, the study from Kalkanli et.al.…”

Section: Ipp and Bph Treatment Optionsmentioning

confidence: 99%

Evaluation of the Accuracy of the Use of Intravesical Prostatic Protrusion Degree as the Predictor of Benign Prostatic Hyperplasia Management

Putri,

Fariz

2024

JIK

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Managing symptoms of benign prostatic hyperplasia (BPH) is important but preventing the progression of the disease is also necessary. Medical therapy is commonly used to treat BPH as initial therapy. However, not every medical therapy is effective for treating BPH. Intravesical prostatic protrusion (IPP), a manifestation of BPH is used to evaluate BPH progression thus helping clinicians in choosing the effective treatment option. Patients with higher IPP degrees may experience more severe bladder outlet obstruction (BOO). They may not respond well to medical therapies, suggesting that IPP measurement can guide treatment decisions for BPH patients. This study evaluates the accuracy of using IPP degree as a predictor of BPH management by reviewing relevant literature. A comprehensive approach was undertaken, including the selection and filtering of articles from reputable databases and scholarly repositories using specific keywords related to the study's objectives. By measuring IPP degrees, the severity of clinical BPH can be categorized, allowing clinicians to choose effective treatment options and predict treatment outcomes.

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“…Significant IPP has been found to be a predictor of failure of α-blocker mono-therapy [10], [32], [41], 5 α-reductase mono-therapy [37] and even combination therapy [42]- [44]. Odd of success of α-blocker therapy is 59 times higher in patients with mild IPP than in those with significant IPP [45].…”

Section: Ipp and Treatment Optionsmentioning

confidence: 99%

A Review of Intravesical Prostatic Protrusion in the Evaluation and Treatment of Benign Prostatic Enlargement

Eze

Amu

Edeh

2021

EJMED

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The evaluation of severity of symptoms, tracking complications, choosing effective and efficient approach to treatment, and prognosis is important in benign prostatic enlargement (BPE) patients. Measurement of intravesical prostatic protrusion (IPP) is an easy, affordable and non-invasive marker for benign prostatic obstruction with a high diagnostic value. This study aims to undertake a descriptive review of current literature for the role of IPP in the evaluation and treatment of patients with BPE. Relevant articles written in English language were retrieved from PubMed and Google Scholar. Keywords used for searching articles included intravesical prostatic Protrusion and Benign Prostatic Enlargement/ hyperplasia/ Obstruction; evaluation; and treatment. Papers published between January 1990 and October 2020 were extracted and evaluated. The analyzed studies showed that IPP can be assessed by various modalities and is important in the evaluation of symptom severity, tracking progression and complications of disease, choosing treatment option and prognostication. It is important that IPP be always assessed at the point of initial evaluation of BPE patients.

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Effect of Intravesical Prostatic Protrusion on the Characteristics of Lower Urinary Tract Symptom Change after 12‐Week Drug Medication: A Prospective Analysis

Abstract: BPH patients with IPP showed less improvement of storage symptoms after 12 weeks of medication. This study suggests that IPP may be a possible cause of intractable storage symptoms in early treatment.

Cited by 8 publications

References 8 publications

Association of Intravesical Prostatic Protrusion Grade and the Outcome of Alpha Blocker Treatment for Bladder Outflow Obstruction

Association of Intravesical Prostatic Protrusion Grade and the Outcome of Alpha Blocker Treatment for Bladder Outflow Obstruction

Evaluation of the Accuracy of the Use of Intravesical Prostatic Protrusion Degree as the Predictor of Benign Prostatic Hyperplasia Management

A Review of Intravesical Prostatic Protrusion in the Evaluation and Treatment of Benign Prostatic Enlargement

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