2022
DOI: 10.3389/fphar.2022.958204
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Effect of iodoacetic acid on the reproductive system of male mice

Abstract: Iodoacetic acid (IAA) is one of the most common water disinfection byproducts (DBPs). Humans and animals are widely and continuously exposed to it. Many species of water DBPs are harmful to the reproductive system of organisms. Nevertheless, the potential effects of IAA exposure on testosterone and spermatogenesis in vivo remain ambiguous. Spermatogenous cells are the site of spermatogenesis, Leydig cells are the site of testosterone synthesis, and Sertoli cells build the blood–testis barrier (BTB), providing … Show more

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Cited by 6 publications
(2 citation statements)
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“…58 In addition, a decrease was detected also in epididymis along with a corresponding reduction in sperm motility. 301 IAA caused Leydig's cell degeneration, reduction in seminiferous tubule, necrotic symptoms, and sperm degeneration. 58 The production of ROS caused by IAA may be the main role in reproductive system damage.…”
Section: Methyl Jasmonate and Anti-inflammatory Effectmentioning
confidence: 97%
See 1 more Smart Citation
“…58 In addition, a decrease was detected also in epididymis along with a corresponding reduction in sperm motility. 301 IAA caused Leydig's cell degeneration, reduction in seminiferous tubule, necrotic symptoms, and sperm degeneration. 58 The production of ROS caused by IAA may be the main role in reproductive system damage.…”
Section: Methyl Jasmonate and Anti-inflammatory Effectmentioning
confidence: 97%
“…Hassan and colleagues showed IAA (5 mg/kg) caused a significant increase in total lipids, cholesterol, concomitant and simultaneously with a significant decrease in total protein and testosterone levels . In addition, a decrease was detected also in epididymis along with a corresponding reduction in sperm motility . IAA caused Leydig’s cell degeneration, reduction in seminiferous tubule, necrotic symptoms, and sperm degeneration .…”
Section: Effects Of Phytohormones On Animalsmentioning
confidence: 99%