Effect of ionic strength on the diffusion coefficient of chondroitin sulfate and heparin measured by quasielastic light scattering

Tivant, P.; Turq, Pierre; Drifford, M.; Magdelénat, H.; Menez, Raphael

doi:10.1002/bip.360220209

Cited by 79 publications

(64 citation statements)

References 38 publications

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“…As can be seen in the figure, D DLS is a decreasing function of J and approaches the value of D NSE at high J-values. The DLS results agree with the theoretical prediction based on the coupling between the polymer and the ion cloud 155,156 (see Fig. 14).…”

Section: Figure 12supporting

confidence: 87%

Recent progress on polymer dynamics by neutron scattering: From simple polymers to complex materials

Colmenero

Arbe

2012

J Polym Sci B Polym Phys

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ABSTRACT:The recent (from 2010 onward) contributions of quasielastic neutron scattering techniques (time of flight, backscattering, and neutron spin echo) to the characterization and understanding of dynamical processes in soft materials based on polymers are analyzed. The selectivity provided by the combination of neutron scattering and isotopic-in particular, proton/deuterium-labeling allows the isolated study of chosen molecular groups and/or components in a system. This opportunity, together with the capability of neutrons to provide space/time resolution at the relevant length scales in soft matter, allows unraveling the nature of the large variety of molecular motions taking place in materials of increasing complexity. As a result, recent relevant works can be found dealing with dynamical process which associated characteristic lengths and nature are as diverse as, for example, phenyl motions in a glassy linear homopolymer like polystyrene and the chain dynamics of a polymer adsorbed on dispersed clay platelets. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 51: 2013 KEYWORDS: molecular dynamics; neutron scattering; relaxation POLYMER DYNAMICS AT DIFFERENT LENGTH AND TIME SCALES: FROM SIMPLE POLYMERS TO COMPLEX MATERIALSPolymers are composed of macromolecules which are built up by a large number N of monomer units linked together by covalent bonds. Because of this macromolecular nature, the structural and dynamic properties of polymeric systems strongly depend on a hierarchy of length and time scales. From a structural point of view, the random coil shape of linear polymer chains in the melt and glassy state-proposed by Flory in the 50s 1 -is nowadays well established by small angle neutron diffraction (SANS). At smaller length scales than those characteristic for the chain dimensions, the local arrangements of the atoms give rise to broad maxima in the static structure factor S(Q) also accessible by neutron diffraction. Usually, a first main peak centered at Q-values ≈ 1 . . . 1.5 Å −1 is present. The T-dependence of this maximum, following the expansion coefficient, indicates an interchain origin, that is, it mainly relates to correlations between atoms belonging to different chains (or to the same chain but well separated segments).2 A second peak located at ∼3 Å −1can also be usually found in S(Q). The small value of the associated characteristic length and its weak T-dependence indicate the intrachain nature of the correlations giving rise to this maximum. We also note that the broadening of the Bragg peaks found in polymers reveals a clear amorphous character. In fact, the features shown in S(Q) in polymeric systems are universal for amorphous materials, not only for polymers, and in particular for glass forming systems. Thus, a universal behavior common for all glass forming materials can also be expected in the dynamics, including the observation of the glass transition phenomenon. 3As anticipated, the complexity of amorphous polymers shows up not only in the structural propertie...

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Section: Figure 12supporting

confidence: 87%

Recent progress on polymer dynamics by neutron scattering: From simple polymers to complex materials

Colmenero

Arbe

2012

J Polym Sci B Polym Phys

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“…This is also what is observed for the fast diffusion process of highly charged polyelectrolytes. The results of Figure 6 can be qualitatively explained by the NernstHartley formula which, however, is strictly valid only at dilutions large enough that the hydrodynamic interactions can be neglected [55,56],…”

Section: Scaling Behaviormentioning

confidence: 75%

Scattering properties of salt-free wormlike micellar solutions

Bellour

Knaebel

Munch

et al. 2000

The European Physical Journal E

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Static and dynamic light scattering and conductivity experiments were carried out on salt-free aqueous micellar solutions of cetyltrimethylammonium n-hexane sulfonate (CTAC6SO3) and cetyltrimethylammonium n-heptane sulfonate (CTAC7SO3) as a function of surfactant concentration. This study confirms the analogy between the behavior in the semi-dilute regime of elongated micellar systems and "classical" polyelectrolyte solutions. Time-resolved scattering experiments performed after a variation of concentration from about twice the overlap volume fraction Φ * to less than half of it revealed the existence of a structural relaxation with a characteristic time of several hours. PACS. 36.20.-r Macromolecules and polymer molecules -61.25.Hq Macromolecular and polymer solutions; polymer melts; swelling -82.70.-y Disperse systems

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“…However, it has been noted [137] that not all heparin-cation interactions may be described in terms of relatively simple charge-density considerations, as described by Manning [138], because diffusion rates of cations were shown to be sensitive to the concentration of Na þ ions [139] and heparin exhibited an apparently lower charge density than predicted [140]. Obvious questions concerning the observation of altered properties and activities of heparin/HS with cations include whether such effects arise from the consequences of changing the charge distribution and/or the resulting altered conformation and flexibility.…”

Section: Cation Binding To Heparan Sulfate/heparin and Its Effectsmentioning

confidence: 99%

Heparan sulfate and heparin interactions with proteins

Meneghetti

Hughes

Rudd

et al. 2015

J. R. Soc. Interface.

256

241

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Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is present within mast cells and can be viewed as a more sulfated, tissuespecific, HS variant. HS and heparin regulate biological processes through interactions with a large repertoire of proteins. Owing to these interactions and diverse effects observed during in vitro, ex vivo and in vivo experiments, manifold biological/pharmacological activities have been attributed to them. The properties that have been thought to bestow protein binding and biological activity upon HS and heparin vary from high levels of sequence specificity to a dependence on charge. In contrast to these opposing opinions, we will argue that the evidence supports both a level of redundancy and a degree of selectivity in the structure-activity relationship. The relationship between this apparent redundancy, the multi-dentate nature of heparin and HS polysaccharide chains, their involvement in protein networks and the multiple binding sites on proteins, each possessing different properties, will also be considered. Finally, the role of cations in modulating HS/heparin activity will be reviewed and some of the implications for structure-activity relationships and regulation will be discussed.

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Effect of ionic strength on the diffusion coefficient of chondroitin sulfate and heparin measured by quasielastic light scattering

Cited by 79 publications

References 38 publications

Recent progress on polymer dynamics by neutron scattering: From simple polymers to complex materials

Recent progress on polymer dynamics by neutron scattering: From simple polymers to complex materials

Scattering properties of salt-free wormlike micellar solutions

Heparan sulfate and heparin interactions with proteins

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