Effect of iontophoresis on in vitro transdermal absorption of almotriptan

Calatayud-Pascual, María Aracely; Balaguer-Fernández, C.; Serna-Jiménez, C.E.; Río‐Sancho, Sergio del; Femenía-Font, A.; Merino, Virginia; López-Castellano, Alicia

doi:10.1016/j.ijpharm.2011.06.039

Cited by 36 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…vertical) Franz cells or horizontal cells, which allow membrane permeation to be investigated, e.g. in porcine skin . In vivo evaluation of the pharmacokinetics of topically administered drugs is more complex.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Trials and tribulations of skin iontophoresis in therapeutics

Roustit

Blaise

Cracowski

2013

Brit J Clinical Pharma

100

View full text Add to dashboard Cite

Iontophoresis is a method of non-invasive transdermal drug delivery based on the transfer of charged molecules using a low-intensity electric current. Both local and systemic administration are possible; however, the skin pharmacokinetics of iontophoretically delivered drugs is complex and difficult to anticipate. The unquestionable theoretical advantages of the technique make it attractive in several potential applications. After a brief review of the factors influencing iontophoresis, we detail the current applications of iontophoresis in therapeutics and the main potential applications under investigation, including systemic and topical drugs and focusing on the treatment of scleroderma-related ulcerations. Finally, we address the issue of safety, which could be a limitation to the routine clinical use of iontophoresis.

show abstract

Section: Pharmacokineticsmentioning

confidence: 99%

Trials and tribulations of skin iontophoresis in therapeutics

Roustit

Blaise

Cracowski

2013

Brit J Clinical Pharma

100

View full text Add to dashboard Cite

show abstract

Section: Electromigrationmentioning

confidence: 99%

“…When electrical current is imposed, these polar aqueous pores are formed as a result of flip-flop movement of polypeptide helices in the stratum corneum. They confer an alternative pathway for drug transport [77][78][79].Nowdays, it has been confirmed that MN will result in creating of aqueous pathways of low electrical resistance. The synergistic effect of iontophoresis and MN technologies can lead to an increased rate of transdermal delivery for a range of drug molecules with the benefit of precise electronic control.…”

mentioning

confidence: 95%

See 1 more Smart Citation

Review on Transdermal Drug Delivery Systems

Pang¹,

Han²

2014

Journal of Pharmaceutics and Drug Development

View full text Add to dashboard Cite

ISSN: 2348-9782 During the past decades, intensive studies have focused on the technologies in drug delivery, and with the rapid developments and explorations in technologies, traditional drug delivery means are being replaced by the more effective and advanced ones. The creation of transdermal drug delivery system (TDDS) has been one of the most sophisticated and innovative approaches of drug deliveries. The transdermal drug delivery system has attracted considerale attention because of its many potential advantages, including better patient compliance, avoidance of gastrointestinal disturbances, hepatic first-pass metabolism and sustained delivery of drugs to provide steady plasma profiles, particularly for drugs with short half-lives, reduction in systemic side effects and enhanced therapeutic efficacy [1][2][3][4][5][6].Recently, transdermal drug delivery system (TDDS) has become a more and more important approach to administering drugs. Based on its advantages, which are not achievable by other modes of administration, many researchers are dedicated to the study of it, and have made great progress. Although the skin offers a painless interface for systemic drug delivery, it also presents limitations which are mainly caused by the stratum corneum. In this work, we state the increasingly impact of TDDS, discuss the limitations of it, and last but not least, we highlight the methods for overcoming these limitations by using permeation enhancers, microneedles, iontophoresis.Despite these advantages, most of the transdermal candidates have low permeability. The drugs administered across skin should have the three constraining characteristics: appropriate partition coefficient, low molecular mass (<500Da), and small required dose (upto milligrams) [3]. The limitations of transdermal drug delivery are caused by skin which protects against and is impermeable to foreign molecules. The human skin is consisted of two main layers: the layer of epidermis and the layer of dermis. Stratum corneum is the epidermis's outermost layer that composed of stratified keratinocytes, multiple lipid bilayers of ceramidas, fatty acids, cholesterol and cholesterol esters. Stratum corneum provides an extremely effective physical barrier for the control of drug penetration [2,[7][8][9][10]. Therefore, attempts to overcome this skin barrier is presently an important area of pharmaceutical and toxicological research. The techniques that weaken the barrier have included permeation enhancers , microneedles and iontophoresis [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84]. Chemical permeation enhancersIn the last 50 years, a large number of chemical permeation enhancers (CPEs) which are defined as substances that interact with the major constituents of skin barrier, stratum corneum, to promote penetration of drugs into skin.The ideal enhancer should have the following conditions: 1. Non-pharmacological activities. 2. Nontoxic,. Rapid-acting with predictable and reproducible activity. 4. When removed from the skin...

show abstract

“…On the other hand, parenteral route lacks both self-administration and acceptance by most individuals. Hence, alternative routes for almotriptan administration were investigated; such as nasal [10,11], transdermal [12], vaginal [13] and pulmonary [14] routes. However, these investigations are scarce [15].…”

Section: Introductionmentioning

confidence: 99%

Flash Dissolving Sublingual Almotriptan Malate Lyotabs for Management of Migraine

Kassem

Labib

2016

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Development of sublingual fast dissolving lyophilized almotriptan tablets, to enhance its pre-gastric absorption and so alleviating the gastrointestinal dysmotility that is commonly associated with migraineurs.Methods: Primary almotriptan lyophilized tablets (Alm-lyotab), were prepared using polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), gelatin, or sodium alginate, as a bulk forming agent and mannitol as a disintegrant, cryoprotectant and taste improver. Physical properties, wetting time, in vitro dissolution and disintegration behaviour, were investigated. A combination of PVP, gelatin and chitosan in different ratios with mannitol were developed and characterised for further improvement. Optimised formula was examined by scanning electron microscope (SEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR).Results: Both PVP and gelatin primary formulations showed elegant appearance with fast in vitro disintegration time of 5.67 and 5.64 sec, short wetting time of 4.06 and 4.05 sec, respectively, and high in vitro release rate of about 80% after 1 min, thus they were selected for further improvement. Optimised formula from polymer blend formulations (F8) which consisted of PVP: gelatin: chitosan in a ratio of its constituting solutions of 1:5:0.5, exhibited an elegant appearance, drug content of 98.75 %, in vivo disintegration time of 1.85 sec and complete drug release within 1 min. SEM micrographs revealed spongy, highly porous structure. DSC results indicated the presence of the drug in its crystalline form. FTIR studies revealed no interaction between the drug and excipients. Conclusion:Sublingual instantly dissolving Almo-lyotab was successfully developed and may constitute an advance in the management of acute migraine attacks.

show abstract

Effect of iontophoresis on in vitro transdermal absorption of almotriptan

Cited by 36 publications

References 36 publications

Trials and tribulations of skin iontophoresis in therapeutics

Trials and tribulations of skin iontophoresis in therapeutics

Review on Transdermal Drug Delivery Systems

Flash Dissolving Sublingual Almotriptan Malate Lyotabs for Management of Migraine

Contact Info

Product

Resources

About