Flash Dissolving Sublingual Almotriptan Malate Lyotabs for Management of Migraine

Kassem, Abeer Ahmed; Labib, Gihan S

doi:10.22159/ijpps.2017v9i1.15489

Cited by 10 publications

(12 citation statements)

References 23 publications

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“…This unidirectional release mechanism of the drug is important because this avoid the clearance of the drug through saliva released by the salivary glands. The most appropriate site of administration for the tablets, which avoids the chances of drug clearance from the buccal cavity, is by administrating the tablets or any other dosage form under the upper lip of the buccal cavity [78]. The marketed Buccastem®, is an adhesive tablet used for anti-emetic action.…”

Section: Tabletsmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.

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Section: Tabletsmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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“…A strip of the formulated OF was placed in a Petri plate containing 25 ml of distilled water at 37°C. After placing the strip in Petri plate, it was swirled at every 10 s. After certain time, the film tends to disintegrate and that time was noted as disintegration time [13,17].…”

Section: In Vitro Disintegration Studiesmentioning

confidence: 99%

Formulation and Evaluation of Oral Disintegrating Film of Atenolol

Sanjay

et al. 2018

Asian J Pharm Clin Res

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Objective: The main objective of the study was to formulate the oral disintegrating films loaded with atenolol by solvent-casting method and to carry out its evaluation studies.Methods: The films were prepared using the film-forming hydrophilic polymer like hydroxypropyl methylcellulose (E-5) and super disintegrant like pectin in various proportions.The formulated oral films were characterized for Fourier transform infrared (FTIR) and morphological evaluations. Various physicochemical parameters such as weight variation, folding endurance, surface pH, in vitro disintegration, and in vitro dissolution studies were carried out.Results: FTIR studies revealed that there was no drug-polymer interaction. The morphological evaluation of films showed that all the films were homogenous and transparent. The folding endurance test ensured that the films had sufficient brittleness and by weight variation test, it was inferred that all the films were within the deviation. The surface pH study showed the pH of the films was around neutral pH. The drug was well distributed in all the films. The films disintegrated within 120 s and the fastest being disintegrated in 30 s. Based on all the evaluation parameters, F6 had shown optimal performance and remarkable increase in drug release of 94.38% in 2 min.Conclusion: Thus, formulated oral disintegrating films can be termed as an alternative approach to deliver atenolol.

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“…Several invasive and non-invasive methods exist for treating the CGH [19,20,22,26]. In spite of being a musculoskeletal disorder, very little focus is given on the muscle system.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of C1-C2 Sustained Natural Apophyseal Glide Combined With Dry Needling on Pressure Point Threshold and Headache Disability in Cervicogenic Headache.

Patra

Mohanty

Gautam

2018

Asian J Pharm Clin Res

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Objective: The main objective of this study was to evaluate the effectiveness of dry needling and mulligan C1-C2 sustained natural apophyseal glides (SNAGs) in increasing pressure point threshold and reducing headache disability in patients with CGH.Methods: This study was conducted on 150 patients. They were divided into three groups for the purpose of the study. Group A was referred to as the dry needling group. They were subjected to dry needling for treating the pain. Group B was the manual therapy group. The patients in this group were subjected to C1-C2 SNAGs. Group C was the combined group. Patients belonging to this group were given C1-C2 SNAGs along with dry needling.Results: Statistical analysis paired t-test was used for comparison of the mean within every group where it showed significant improvement in all the parameter (p<0.05). Conclusion:There was a consistent reduction in tenderness and improvement in disability of the patients belonging to all groups. However, Group C, where the patients were subjected to combined treatment, showed better results. Results of this study indicate that dry needling along with mulligan C1-C2 SNAGs is more beneficial in patients suffering from cervicogenic headaches.

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Flash Dissolving Sublingual Almotriptan Malate Lyotabs for Management of Migraine

Cited by 10 publications

References 23 publications

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

Formulation and Evaluation of Oral Disintegrating Film of Atenolol

Effectiveness of C1-C2 Sustained Natural Apophyseal Glide Combined With Dry Needling on Pressure Point Threshold and Headache Disability in Cervicogenic Headache.

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