Effect of Iron on the Biosynthesis of Hepatic Apoferritin 1

Korey, Saul R.; Levine, Bennett

doi:10.1172/jci103130

Cited by 7 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since its discovery in 1937 [64] the intriguing properties of ferritin have stimulated many insightful studies that have helped elucidate the major mechanisms for sensing and controlling cellular and organismal iron homeostasis in vertebrates. Initial studies by Granick and others demonstrated that ferritin abundance and synthesis were iron-responsive [65][66][67]. Munro and colleagues, as well as others, made the critical observation that mammalian cells contained a cytosolic iron sensor that controlled ferritin synthesis [68][69][70].…”

Section: Irps Are Key Iron Sensors In Vertebratesmentioning

confidence: 99%

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Wallander

Leibold

Eisenstein

2006

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

255

248

View full text Add to dashboard Cite

Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins post-transcriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.

show abstract

Section: Irps Are Key Iron Sensors In Vertebratesmentioning

confidence: 99%

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Wallander

Leibold

Eisenstein

2006

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

255

248

View full text Add to dashboard Cite

show abstract

“…Initial studies demonstrated that ferritin abundance and synthesis were ironresponsive [176][177][178] and that mammalian cells contained a cytosolic iron sensor that controlled ferritin synthesis. [179][180][181] In 1976, Munro and coworkers 182 demonstrated that iron stimulated ferritin synthesis by activating the translation of ferritin mRNAs.…”

Section: A Iron-responsive Elementsmentioning

confidence: 99%