Effect of Iron Therapy on the Whole Blood Platelet Aggregation in Infants with Iron Deficiency Anemia*

Kürekçi, Ahmet Emin; Atay, Avni; Sarıcı, S. Ümit; Zeybek, Cengiz; Köseoğlu, Vedat; Özcan, Okan

doi:10.1016/s0049-3848(99)00150-4

Cited by 21 publications

(22 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a few studies investigating platelet aggregation in children with IDA with conflicting results [1,2,11,12]. Tekin et al [12] reported that platelet aggregation responses to collagen and ADP are significantly higher in iron-deficient children than in controls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet function alterations and their relation to P-selectin (CD62P) expression in children with iron deficiency anemia

Yıldırım¹,

Orhan²,

Büyükavcı³

2011

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Iron deficiency anemia (IDA) may cause platelet aggregation dysfunction and this can be reversed by iron therapy. On the other hand, it has been reported that the platelet fractions carrying the platelet activation markers, CD62P and CD63, are increased in thalassemic patients and there is a significant correlation between the increased levels of soluble P-selectin and free iron in sickle cell disease. This study was performed to investigate the alterations of platelet functions and whether iron deficiency results in diminished expression of activation marker (P-selectin; CD62P) leading to platelet aggregation dysfunction in children with IDA. Hemoglobin, erythrocyte indices (mean erythrocyte volume and red blood cell distribution width), serum levels of iron, transferrin and ferritin, platelet aggregation tests (with ADP, collagen, and ristocetin), PFA-100 closure time, and CD62P expression were evaluated in fasting blood samples of 22 children with IDA and 20 children without anemia. CD62P expression was detected by flow cytometry in normal and 5 μmol/l ADP-activated platelets. Mean closure times were longer in the patient group than control. In platelet aggregation tests, mean values of maximum aggregation times by ristocetin, ADP, and collagen were also more prolonged in patient group. Ristocetin-induced maximum aggregation rates (amplitude) were significantly higher in patients. However, ADP and collagen induction did not produce the same effect. CD62P expressions were significantly higher on activated platelets of the patient group, although they were similar in both groups before activation by ADP. These findings suggest that platelet aggregation and adhesion have been delayed in children with IDA; however, platelet function abnormalities are not associated with CD62P expression on platelet surface.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It has been reported that iron deficiency anemia (IDA) may cause platelet aggregation dysfunction and this can be reversed by iron therapy [1][2][3]. Although it is thought that iron-containing enzymes of the platelets might have a role, the main cause of this abnormality is not clear.…”

Section: Introductionmentioning

confidence: 99%

Platelet function alterations and their relation to P-selectin (CD62P) expression in children with iron deficiency anemia

Yıldırım¹,

Orhan²,

Büyükavcı³

2011

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

show abstract

“…However, this view is an oversimplification because systematic studies show a decreased maximum aggregation and a prolongation of aggregation time in thrombelastography in patients with iron deficiency anemia compared to controls [9,18], while isovolemic hemodilution leads to a shortening of reaction and coagulation times in a hematocrit dependent manner [16,21]. In this study only severe anemia was independently associated with CVT, which might be interpreted as a higher dependence of hypercoagulability on the hemoglobin and hematocrit levels rather than on the extent of thrombocytosis.…”

Section: Discussionmentioning

confidence: 99%

Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Kürekçi et al [10] studied platelet aggregation induced by various concentrations of ADP and collagen with impedance aggregometry in 25 iron-deficient children before and after therapy. The posttreatment mean maximum aggregation values were significantly higher in their study.…”

Section: Discussionmentioning

confidence: 99%

“…Qualitative and quantitative changes in the platelets of patients with IDA have been described to be shown by increased platelet counts [5,6] and a tendency to thrombosis [5,7,8] as well as thrombocytopenia [9] and platelet dysfunction [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron Therapy on Platelet Function among Iron-Deficient Women with Unexplained Menorrhagia

Akay

Akin²,

Mutlu³

et al. 2007

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

This study was performed to evaluate the effect of iron therapy on platelet function among women with unexplained menorrhagia in order to better understand possible interactions between iron deficiency anemia and platelet behavior and menorrhagia. Platelet aggregation and adenosine triphosphate (ATP) release induced by 5.0 mM adenosine diphosphate (ADP), 0.5 mM arachidonic acid (AA), 1.0 mg/ml ristocetin and 2 μg/ml collagen were studied by whole-blood platelet lumi-aggregometer in 50 menorrhagic women before and after oral iron therapy and in 22 women of the control group. There was a significant increase in AA- induced platelet aggregation (p < 0.05) and a decrease in ristocetin-induced platelet aggregation (p < 0.01) after treatment. Pre- and posttreatment platelet aggregation responses to ADP and collagen were not significantly different (p > 0.05). Pre- and posttreatment platelet secretion responses to all agonists disclosed no significant difference (p > 0.05). There was no significant difference between the study group after treatment and the control group in respect to platelet aggregation and ATP secretion values induced by all agonists (p > 0.05). We conclude that iron deficiency anemia in women causes AA-induced platelet dysfunction, which may give rise to increased menstrual blood loss and can be reversed by iron repletion.

show abstract

Effect of Iron Therapy on the Whole Blood Platelet Aggregation in Infants with Iron Deficiency Anemia*

Cited by 21 publications

References 5 publications

Platelet function alterations and their relation to P-selectin (CD62P) expression in children with iron deficiency anemia

Platelet function alterations and their relation to P-selectin (CD62P) expression in children with iron deficiency anemia

Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited

Effect of Iron Therapy on Platelet Function among Iron-Deficient Women with Unexplained Menorrhagia

Contact Info

Product

Resources

About