Effect of irradiation on the plasminogen activator content in rat vessels

Åstedt, Birger; Bergentz, Sven‐Erik; Svanberg, L

doi:10.1007/bf01919698

Cited by 23 publications

(8 citation statements)

References 4 publications

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“…1). This is in agreement with observations in animal experiments by Astedt et al (12) and with the present finding of still low values in the patients examined 2) years after irradiation, which suggests a permanent inhibition of the synthesis of the activators. The results might help to explain such things as increased frequency of thrombosis, change in tissue repair and inhibition of tumour growth in irradiated patients.…”

Section: Discussionsupporting

confidence: 94%

On Radiation‐Decreased Fibrinolytic Activity of Vessel Walls

Svanberg

Åstedt

Kullander

1976

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 94%

On Radiation‐Decreased Fibrinolytic Activity of Vessel Walls

Svanberg

Åstedt

Kullander

1976

Acta Obstet Gynecol Scand

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“…In the acute phase, radiation increases endothelial cell permeability and expression of chemokines and adhesion molecules, and causes loss of vascular thromboresistance (3,4). Radiation-induced loss of vascular thromboresistance is a result of decreased fibrinolytic activity (24), increased expression of tissue factor (TF) (25,26) and von Willebrand factor (27), and decreased expression of prostacyclin (28) and TM (5,(29)(30)(31). TM is a transmembrane glycoprotein, located on the luminal surface of endothelial cells in most normal blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Simvastatin Ameliorates Radiation Enteropathy Development After Localized, Fractionated Irradiation by a Protein C-Independent Mechanism

Wang

Boerma

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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“…Drugs able to affect the suppression of fibrinolysis include actinomycin D, dextran sulfate (a fibrinolytic stimulator) and angiotensin converting enzyme (ACE) inhibitors, as reviewed by Ward (90). There is reduced PA activity, leading to depressed fibrinolysis, in blood vessels (99, 100), liver (101) and lung (102–104). There is radiographic evidence of the beneficial effects of dextran sulfate in the treatment of human pulmonary radiation injury (105).…”

Section: Introduction/background Informationmentioning

confidence: 99%

A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments

2016

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Results from our recent studies have led to the novel hypothesis that radiation-induced coagulopathy (RIC) and associated hemorrhage occurring as part of the acute radiation syndrome (ARS) is a major cause of death resulting from radiation exposure in large mammals, including humans. This article contains information related to RIC, as well as potential strategies for the prevention and treatment of RIC. In addition, new findings are reported here on the occurrence of RIC biomarkers in humans exposed to radiation. To determine whether irradiated humans have RIC biomarkers, blood samples were obtained from radiotherapy patients who received treatment for different types of malignancies. Blood samples from allogeneic hematopoietic cell transplantation (allo-HCT) patients obtained before, during and after irradiation indicated that exposure led to prolonged clot formation times, increased levels of thrombin-antithrombin III (TAT) complex and increased circulating nucleosome/ histone (cNH) levels, which suggest potential coagulopathies in the allo-HCT patients. Since these allo-HCT patients received chemotherapy prior to radiotherapy, it is possible that the chemical agents could have influenced the observed results. Frozen plasma samples from radiotherapy patients with prostate, lung and breast cancer were also obtained for analyses of cNH levels. The results indicated that some of these patients had very high cNH blood levels. Analysis of cNH levels in plasma samples from irradiated ferrets also indicated increased cNH levels compared to preirradiation baseline levels. The results from irradiated animals and some radiotherapy patients suggest the possibility that anti-histone antibodies, which block the toxic effects of elevated cNH levels in the blood, might be useful as therapeutic agents for adverse biological radiation-induced effects. The detection of increased levels of cNH in some radiotherapy patient blood samples demonstrates its potential as a biomarker for diagnosing and/or predicting the propensity for developing coagulopathies/hemorrhage, offering possible treatment options with personalized medicine therapies for cancer patients.

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Effect of irradiation on the plasminogen activator content in rat vessels

Cited by 23 publications

References 4 publications

On Radiation‐Decreased Fibrinolytic Activity of Vessel Walls

On Radiation‐Decreased Fibrinolytic Activity of Vessel Walls

Simvastatin Ameliorates Radiation Enteropathy Development After Localized, Fractionated Irradiation by a Protein C-Independent Mechanism

A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments

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