Effect of KCA-098 on the function of osteoblast-like cells and the formation of TRAP-positive multinucleated cells in a mouse bone marrow cell population

Kawashima, Keisuke; Inoue, Takeshi; Tsutsumi, Naoyuki; Endo, Hiroyoshi

doi:10.1016/0006-2952(95)02126-4

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…This suggests that, depending on timing, duration of treatment and possible isoflavone concentration, there are bidirectional effects on anxiety. This is similar to the bidirectional effects of soya isflavones that have been reported for oestrogen-sensitive responses in mammary cells and bone marrow (Kawashima et al 1996;Cotroneo et al 2002). It has been suggested that aromatase inhibition could account for this pattern of effects, since low concentrations of phytoestrogens were found to be aromatase inhibitors, thus inhibiting conversion from testosterone to 17b-oestradiol; whereas at high concentrations they had oestrogenic actions (Almstrup et al 2002).…”

Section: Discussionsupporting

confidence: 75%

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat

et al. 2003

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Section: Discussionsupporting

confidence: 75%

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat

et al. 2003

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“…These agents include phytoestrogens, soy bean isoflavones (31-33) and a variety of synthetic compounds, such as the isofiavone derivative 7-iso propoxy-3-phenyl-4H-l-benzopyran-4-one (ipriflavone) (34). Chemically, many of the known phytoestrogens are flavonoids; others are coumestans (35) or resorcylic acid lactones, and an estrogenic hydroxystilbene was recently reported to occur naturally in wood (14). The phytoestrogen resveratrol has recently been revealed to exhibit variable degrees of estrogen receptor agonism (16).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates Ovariectomy-Induced Hypertension and Bone Loss in Stroke-Prone Spontaneously Hypertensive Rats.

Mizutani¹,

Ikeda

Kawai

et al. 2000

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

115

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SummaryWe examined the effect of resveratrol (3, 4', 5-trihydroxy stilbene), a phenolic compound found in the skins of most grapes, on blood pressure and bone loss in ovariec tomized (OVX), stroke-prone spontaneously hypertensive rats (SHRSP). Nineteen-week-old female SHRSP were divided into a sham-ovariectomized (sham) group fed a control diet and two OVX groups fed either a control diet (OVX-Cont) or a diet supplemented with resveratrol (5mg/kg per d; OVX-Resv). Ovariectomy induced significant increases in systolic blood pressure (SBP). Resveratrol lowered the SBP by 15% by the third week of administration, and this effect was maintained throughout the study. Resveratrol treatment also signifi cantly enhanced endothelium-dependent vascular relaxation in response to acetylcholine (ACh) in OVX rats. Finally, femur breaking energies measured for the resveratrol-treated (OVX-Resv) group were significantly higher than those of the resveratrol-untreated (OVX -Cont) group. While no significant differences in calcium, magnesium and phosphorus con tent were found between the femurs of OVX-Cont and OVX-Resv rats, the femur hydroxy proline content in the OVX-Resv group was significantly higher than of the OVX-Cont group. We conclude that, in OVX-SHRSP, resveratrol acts by a similar mechanism to mam malian estrogens, lowering blood pressure by increasing dilatory responses to ACh . The present study also demonstrated that resveratrol was able to prevent ovariectomy-induced decreases in femoral bone strength.

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“…Phytoestrogens are effective in preventing bone loss in ovariectomized rats and postmenopausal women (Draper et al, 1997;Morabito et al, 2002). It has been shown that genistein inhibited bone loss caused by estrogen deficiency in mice (Cotter and Cashman, 2003;Ishimi et al, 1999), and an analog of coumestrol increased alkaline phosphatase (ALP) activities, one of the osteoblastic phenotype markers, in osteoblast-like cells (Kawashima et al, 1996). These results suggest that phytoestrogens may prevent bone loss.…”

Section: Introductionmentioning

confidence: 99%

Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3‐E1 cells

Lee

Choi

2006

Phytotherapy Research

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The ethanol extract from the bark of Cinnamomum cassia Blume (CCE) was tested for estrogenic activity. CCE (4-60 microg/mL) significantly induced the growth of MCF-7 cells, an ER-positive human breast cancer cell line, over that of untreated control cells (p < 0.05). In the ER competitive binding assay, CCE showed higher affinity with ERbeta compared with ERalpha. To investigate the bioactivities of CCE, which act on bone metabolism, the effects of CCE on the function of osteoblastic MC3T3-E1 cells and the production of local factors in osteoblasts were studied. CCE (4-60 microg/mL) dose-dependently increased the survival of MC3T3-E1 cells. In addition, CCE (10 and 50 microg/mL) increased alkaline phosphatase (ALP) activity, collagen synthesis and osteocalcin secretion in MC3T3-E1 cells. Treatment with CCE (10 and 50 microg/mL) prevented apoptosis induced by TNF-alpha (10(-10) m) in osteoblastic cells. In the presence of TNF-alpha, culture with CCE (10-100 microg/mL) for 48 h inhibited the production of IL-6 and nitric oxide in osteoblastic MC3T3-E1 cells. These results suggest that Cinnamomum cassia has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention of osteoporosis and inflammatory bone diseases.

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Effect of KCA-098 on the function of osteoblast-like cells and the formation of TRAP-positive multinucleated cells in a mouse bone marrow cell population

Cited by 17 publications

References 27 publications

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat

Resveratrol Attenuates Ovariectomy-Induced Hypertension and Bone Loss in Stroke-Prone Spontaneously Hypertensive Rats.

Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3‐E1 cells

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