Effect of Ketamine Spraying on the Postoperative Sore Throat and Hoarseness after Tracheal Intubation

Ayatollahi, Vida; Moslemin, Faride; Shekufeh, Behdad; Hatami, Maryam

doi:10.9734/bjmmr/2016/26873

Cited by 2 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all, 30 including 2278 participants provided data on the incidence of sore throat at 24 hours after surgery/extubation . Topical application of ketamine was associated with a reduced incidence of postoperative sore throat compared to non‐analgesic methods (159/1161 vs 384/1117; RR, 0.45; 95% CI, 0.37‐0.54; P < .001; I 2 = 23.0%; Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…In all, 15 studies reported that there were no systemic or local adverse events . One study reported that there were no differences in adverse events between topical ketamine and non‐analgesic methods . Another study reported that there were no psychomimetic effects related to ketamine…”

Section: Resultsmentioning

confidence: 99%

“…Ketamine was topically administered as a single dose prior to surgery in all studies. Ketamine was administered as nebulization and gargle in 13 40,49,56,58,60,61,63,65,67,68,70,72,74 and 26 trials, [36][37][38][39][41][42][43][44][45][46][47][48][50][51][52][53]55,57,59,62,64,66,69,71,73,75,76 respectively, and in the other one, the endotracheal tube was lubricated with ketamine. 54 The dose of ketamine was fixed in 36 studies (50 mg, 23 studies 37,39,44,[48][49][50][51][52][53]…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…A total of 14 studies examined both non-analgesic and active comparators. [42][43][44]46,53,57,60,63,65,68,69,73,75,76 In all, 22 studies were reported from India, six from Iran, 43,46,[54][55][56]76 three each from China 40,44,71 and Egypt, 42,57,68 two each from Indonesia 47,59 and Nepal, 39,77 and one each from Malaysia, 38 South Korea, 51 and Turkey. 36 All but six studies were reported in English: three in Chinese, 40,44,71 two in Indonesian, 47,59 and one in Persian.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…36 All but six studies were reported in English: three in Chinese, 40,44,71 two in Indonesian, 47,59 and one in Persian. 76 In total, 27 studies used a four-level classification system to rate the presence and severity of postoperative sore th roat [36][37][38][39][40][41][44][45][46][47][48]54,56,59,60,[62][63][64][65][66][67][68][69][70]72,74,75 and 10 reported its incidence. 42,49,50,52,55,57,58,61,71,73 Six studies and two used a visual analogue scale 44,51,55,57,71,76 and numerical rating scale, …”

Section: Overview Of Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Kuriyama

Nakanishi

Kamei

et al. 2020

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Background Postoperative sore throat is a leading undesirable postoperative outcome. Ketamine is an N‐methyl‐d‐aspartate receptor antagonist and its topical application is used for chronic pain and oral/throat indications. We conducted a systematic review to assess the efficacy of preoperative, topical ketamine application for preventing postoperative sore throat. Methods We searched MEDLINE, EMBASE, and CENTRAL through September 23, 2019 for randomized controlled trials in which at least one intervention was topical ketamine to prevent postoperative sore throat in adults undergoing endotracheal intubation. The primary outcome was the incidence of sore throat at 24 hours postoperatively. The comparators were non‐analgesic controls (placebo, no treatment, or usual care) or active agents. We pooled the data using a random‐effects model. Results We included 41 randomized controlled trials involving 3784 participants. Topical ketamine was associated with reduced incidence of sore throat at 24 hours postoperatively compared to non‐analgesic methods (risk ratio, 0.45; 95% CI, 0.37‐0.54; P < .001). We found significant publication bias, but the results remained unchanged with a trim‐and‐fill analysis. Trial sequential analysis (TSA) suggested that the efficacy of topical ketamine was adequate (TSA‐adjusted 95% CI, 0.33‐0.56). The GRADE quality for this evidence was moderate. Topical ketamine was inferior to a combination of nebulized ketamine and clonidine in preventing postoperative sore throat. Conclusions Preoperative, topical ketamine application may be more effective than non‐analgesic methods in preventing postoperative sore throat. The number of studies did not suffice to determine the place of topical ketamine among agents to prevent postoperative sore throat.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Kuriyama

Nakanishi

Kamei

et al. 2020

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

Ren

Min

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Postoperative sore throat is one of the most common complications following endotracheal intubation. Nebulization therapy, a preferable and safety method of drug delivery, has been shown to be effective in postoperative sore throat prevention in many studies. However, the relative efficacy of various nebulized agents remains unknown. In this review, we aimed to quantify and rank order the efficacy of available nebulized agents for various postoperative sore throat-related outcomes. A comprehensive literature search of PubMed, EMBASE, CENTRAL and Google Scholar was conducted to identify eligible studies from inception to 25 May 2020. Incidence of postoperative sore throat 1hour and 24hours postoperatively and severity of postoperative sore throat 24 hours postoperatively were the primary outcomes. We conducted a Bayesian network meta-analysis to combine direct and indirect evidence to estimate the relative effects between treatments as well as the probabilities of ranking for treatments based on their protective effects. We identified 32 trials assessing 6 interventions. Overall inconsistency and heterogeneity were acceptable. Nebulized corticosteroids, magnesium, and ketamine differed from non-analgesic methods on the three primary outcomes. Based on the surface under the cumulative ranking curve, nebulized corticosteroids ranked first in almost all outcomes among the nebulized drugs. Considering only high-quality and 2-arm design studies, nebulized corticosteroids still seemed best. In conclusion, prophylactic use of nebulized corticosteroids, magnesium, and ketamine can effectively prevent postoperative sore throat, and nebulized corticosteroids appears to be the overall best approach.

show abstract

Effect of Ketamine Spraying on the Postoperative Sore Throat and Hoarseness after Tracheal Intubation

Cited by 2 publications

References 18 publications

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

Contact Info

Product

Resources

About