Effect of kolaviron, a biflavonoid complex from<i>Garcinia kola</i>seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats

Adaramoye, Oluwatosin A.; Lawal, S. O. A.

doi:10.1111/and.12160

Cited by 23 publications

(18 citation statements)

References 44 publications

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“…The study conducted by Adaramoye and Lawal (2014) on diabetic male rats showed that metformin is able to restore follicle-stimulating hormone, leutinizing hormone, and testosterone (Adaramoye, Lawal, 2014). Likewise, oral administration of metformin succeeded to restore testosterone level back to normal in diabetic rats (Ayuob, Murad, Ali, 2015).…”

Section: Positive Effectsmentioning

confidence: 98%

“…Later in vivo system study on diabetic rats clearly showed that oral treatment with metformin (50 mg/kg/day, for 4 weeks) in combination with pioglitazone, another antidiabetic drug, at 1 mg/kg increases the caudal sperm count and decreases sperm morphology defects 592 (Rabbani, Devi, Khanam, 2010). Moreover, epididymal sperm count, motility, and morphology were improved in diabetic rats upon treatment with metformin at 30 mg/kg/ day for 6 weeks (Adaramoye, Lawal, 2014). Furthermore, diet-induced obesity rats fed orally with metformin for 12 weeks had higher epididymal sperm count and motility (Fang et al, 2012).…”

Section: Positive Effectsmentioning

confidence: 99%

“…One obvious mechanism is that metformin reduces the level of oxidative stress (Banihani et al, 2014), an imbalance between oxidants and antioxidants to the favor of the former, and lipid peroxidation (Attia, Helal, Alhaider, 2009). It has been shown that metformin supplementation at 30 mg/kg restores the antioxidant function such as reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase in diabetic male rats (Adaramoye, Lawal, 2014). Similar findings of enhancing the antioxidant function were observed when using diet-induced obesity rats (i.e., higher superoxide dismutase and glutathione peroxidase, and lower malondialdehyde) (Fang et al, 2012).…”

Section: Positive Effectsmentioning

confidence: 99%

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Effect of metformin on semen quality

Banihani

2016

Braz. J. Pharm. Sci.

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Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.Uniterms: Metformin/effects. Metformin/review. Metformin/semen quality. Sperm/study. Testosterone. Oxidative stress. 5'-AMP activated protein kinase. INTRODUCTIONMetformin, a biguanide-derivative antidiabetic drug, is the most widely used oral agent in humans (Brinkmann, Brixius, 2015;Chhetri, Thapa, Van Schepdael, 2014). It is the first-line drug for the treatment of type 2 diabetes, particularly, in overweight and obese patients with normal kidney function (American Diabetes, 2009;George, Joseph, 2014;Hung et al., 2015). In addition, recent research has proposed that metformin alone or in combination with insulin may be safe to treat gestational diabetes and does not increase the risk of metabolic acidosis (Huang, Castelino, Peterson, 2015; Kitwitee et al., 2015). Metformin's mechanism of action involves suppression of hepatic gluconeogenesis (Ferrannini, 2014; Foretz et al., 2010;Todd, Florez, 2014). One concern that has been raised relevant to metformin usage is that the consensus panel of diabetes felt that metformin should be considered for diabetes prevention even in non-diabetic individuals (i.e., pre-diabetic or obese individuals). This concern increases the use of this drug by these groups (American Diabetes, 2009;Hostalek, Gwilt, Hildemann, 2015;Manu et al., 2015;McGavock, Dart, Wicklow, 2015).Over the last decade, various experimental and clinical studies have linked metformin with sperm function, and thus with male factor infertility Ferreira et al., 2015); however, such direct link has not been established. In this review, we provide fresh and comprehensive understanding of the effect of metformin, as a universally used oral agent, on semen quality (i.e., sperm quantity and quality). To do this, we searched the MEDLINE electronic database for English-language articles and abstracts reported using the key words 'metformin' and 'sperm'. The references from selected articles were reviewed and used if relevant. Effect of metformin on sperm parameters Positive effectsTo date, the majority of studies linking metformin to sperm parameters are nonclinical. In his study on streptozotocin-induced diabetic rats, Attia, Helal, Alhaider (2009) made the seminal observation that metformin decreases the diabe...

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Section: Positive Effectsmentioning

confidence: 98%

Section: Positive Effectsmentioning

confidence: 99%

Section: Positive Effectsmentioning

confidence: 99%

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Effect of metformin on semen quality

Banihani

2016

Braz. J. Pharm. Sci.

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“…Spermatozoa are particularly susceptible to lipid peroxidation (peroxidative damage) due to high concentration of PUFAs, which are related to arranging of spermatogenesis, sperm maturation, acrosome reaction, capacitation and poor antioxidant capacity and membrane fusion. The process of LPO in spermatozoon might demolish the lipid structure of spermatozoa membranes, also it may cause to fast loss of the intracellular ATP, decrease sperm viability, increase medium grade morphological defects and inhibit spermatogenesis in extreme situations (Adaramoye & Lawal, ; Farombi & Nwaokeafor, ; Vernet, Aitken, & Drevet, ). The excessive Cu in diet of rats might cause the membrane damage and LPO.…”

Section: Discussionmentioning

confidence: 99%

“…The levels of Cu in seminal plasma and serum of fertile male rats were significantly lower than those in subfertile male rats (Aydemir et al, 2006;Eidi et al, 2010). (Adaramoye & Lawal, 2014;Farombi & Nwaokeafor, 2005;Vernet, Aitken, & Drevet, 2004). The excessive Cu in diet of rats might cause the membrane damage and LPO.…”

Section: Discussionmentioning

confidence: 99%

Bee glue (propolis) improves reproductive organs, sperm quality and histological changes and antioxidant parameters of testis tissues in rats exposed to excess copper

Seven

Baykalır

et al. 2020

Andrologia

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This study was designed to determine the effects of propolis on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to excessive copper (Cu). In this aim, 24 rats were randomly divided into four groups as follows: the control, Cu, Propolis and Cu+Propolis. When compared to control group, Cu administration significantly decreased sperm motility and concentration, increased total abnormal sperm rate. It caused a significant induction the malondialdehyde (MDA), and reduction the superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in testicular tissues. Also, it caused loss, disorganisation and vacuolation of the germinal epithelium, oedema of the interstitial tissues, proliferation of the interstitial cells, spilled immature spermatogenic cells in the lumen of some seminiferous tubules. A large number of active caspase‐3‐positive stained apoptotic cells and a significant decrease in Johnsen's testicular score were determined. However, significant ameliorations were observed in all sperm characteristics, MDA, SOD, CAT, GSH, seminiferous tubules, number of apoptotic cells and Johnsen's testicular score in Cu+Propolis group. Our results showed that oral supplementation of propolis had curative effect on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to Cu.

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