Effect of kolaviron on islet dynamics in diabetic rats

Oyenihi, Omolola R.; Cerf, M; Matsabisa, Motlalepula G.; Brooks, Nicole L; Oguntibeju, Oluwafemi Omoniyi

doi:10.1016/j.sjbs.2021.08.095

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…Though there is no generally accepted mechanism of action yet, KV was suggested to produce its antidiabetic effect via inhibition of α-glucosidase and α-amylase activities (Iwu et al 1990b ; Salau et al 2020 ). Recent study has also suggested that KV may play a regenerative role in pancreatic islets in streptozotocin-induced diabetic rats (Oyenihi et al 2021 ). Other studies focused on the KV ability to reduce secondary pathology complications associated with diabetes, including hepatoxicity, nephrotoxicity, and cardiotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from G. kola, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of G. kola. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in G. kola may be used as a lead in the drug development.

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Section: Resultsmentioning

confidence: 99%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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“…The pharmacological properties of GK seeds are attributed to their complex mixture of biflavonoids, polyphenolic compounds, and prenylated benzophenones. Kolaviron is one of the biflavonoids that are extracted from GK seeds and is known as the most active phytochemical in these seeds [ 208 ]. Normal consumption levels of GK seeds are considered safe for human [ 207 ].…”

Section: Natural Products and Compounds As Possible Agents To Counter...mentioning

confidence: 99%

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Das,

Sakr,

Al-Huseini

et al. 2023

Plants

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There are various herbicides which were used in the agriculture industry. Atrazine (ATZ) is a chlorinated triazine herbicide that consists of a ring structure, known as the triazine ring, along with a chlorine atom and five nitrogen atoms. ATZ is a water-soluble herbicide, which makes it capable of easily infiltrating into majority of the aquatic ecosystems. There are reports of toxic effects of ATZ on different systems of the body but, unfortunately, majority of these scientific reports were documented in animals. The herbicide was reported to enter the body through various routes. The toxicity of the herbicide can cause deleterious effects on the respiratory, reproductive, endocrine, central nervous system, gastrointestinal, and urinary systems of the human body. Alarmingly, few studies in industrial workers showed ATZ exposure leading to cancer. We embarked on the present review to discuss the mechanism of action of ATZ toxicity for which there is no specific antidote or drug. Evidence-based published literature on the effective use of natural products such as lycopene, curcumin, Panax ginseng, Spirulina platensis, Fucoidans, vitamin C, soyabeans, quercetin, L-carnitine, Telfairia occidentalis, vitamin E, Garcinia kola, melatonin, selenium, Isatis indigotica, polyphenols, Acacia nilotica, and Zingiber officinale were discussed in detail. In the absence of any particular allopathic drug, the present review may open the doors for future drug design involving the natural products and their active compounds.

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Molecules and targets of antidiabetic interest

Gawli,

Bojja

2024

Phytomedicine Plus

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Effect of kolaviron on islet dynamics in diabetic rats

Cited by 4 publications

References 53 publications

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Molecules and targets of antidiabetic interest

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