Effect of l-asparaginase therapy upon serum pseudocholinesterase and ceruloplasmin levels in patients with acute leukemia

Cucuianu, M; Bornuz, F; Macavei, I

doi:10.1016/0009-8981(72)90213-6

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Effect Of Drugs and Chemicals1

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1975

2023

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“…In general, the decrease in serum cholinesterase levels is nonspecific and can occur with nutritional deficiencies and liver dysfunction. Furthermore, it is a known side effect of L-Asp [ 5 ]. In our case, these changes were associated with serum albumin levels and were observed after repeated administration of L-Asp (Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

A Case of L-Asparaginase-Induced Severe Hepatic Steatosis With Decreased Serum Cholinesterase Levels

Takata,

Nakashima,

Shakado

et al. 2023

Cureus

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L-asparaginase (L-Asp) is a useful antileukemic agent for acute lymphoblastic leukemia (ALL); however, it often causes severe liver injury with marked fatty liver. Here, we present a case of L-Asp-induced fatty liver disease in a 21-year-old female patient with ALL. Serum cholinesterase levels, which are usually elevated in fatty liver, decrease at the onset of liver injury. After treatment with L-carnitine and vitamin B complex, the liver injury rapidly improved, resulting in the patient being able to continue subsequent chemotherapy.

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Section: Discussionmentioning

confidence: 99%

A Case of L-Asparaginase-Induced Severe Hepatic Steatosis With Decreased Serum Cholinesterase Levels

Takata,

Nakashima,

Shakado

et al. 2023

Cureus

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“…Asparaginase (Cucuianu et al, 1972), danazol (Laurell and Rannevik, 1979) and glucocorticoids decrease BuChE probably by inhibiting hepatic synthesis (Verjee et al, 1977). Iodipamide, a radio contrast media is a powerful inhibitor of BuChE (Lasser and Lang, 1966).…”

Section: Effect Of Drugs and Chemicalsmentioning

confidence: 99%