Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

Civitelli, Roberto; Fedde, Kenton N.; Harter, Jim; Halstead, Linda R.; Gennari, C; Avioli, Louis V.

doi:10.1007/bf02556063

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…It is well known that lysine is crucial in protein synthesis for growth of tissues. Lysine is also involved in the cross linking process of bone collagen and in the biosynthesis of carnitine and elastin (Civitelli et al, 1992;Flodin, 1997). Similarly, tryptophan is an essential amino acid and the biological precursor of niacin.…”

Section: Discussionmentioning

confidence: 99%

Replacement of Normal Maize with Quality Protein Maize on Performance, Immune Response and Carcass Characteristics of Broiler Chickens

Panda¹,

Raju²,

Rao³

et al. 2010

Asian Australas. J. Anim. Sci

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An experiment was conducted to evaluate the effect of dietary replacement of normal maize (NM) with quality protein maize (QPM) on performance, immune response and carcass characteristics of broiler (Krishibro) chickens. Six experimental diets were prepared separately for starter and finisher phases. Diet 1 was a control diet formulated with NM and soybean meal. In diets 2-5, the NM was replaced with QPM at 25, 50, 75 and 100%, respectively. Diet 6 was the same as the control diet, but supplemented with synthetic lysine similar to the industry standard. Each test diet was fed to 8 replicates, each of 5 chicks, reared in stainless steel battery brooders. The AME content of QPM (3382 kcal/kg) was similar to that of NM (3,352 kcal/kg), but protein (9.91 vs. 8.94%), lysine (0.40 vs. 0.26%) and tryptophan (0.09 vs. 0.07%) contents of QPM were higher than NM. Dietary replacement of NM with 50% QPM significantly (p<0.05) improved body weight gain, feed conversion ratio, humoral immune response, relative bursa weight, and breast muscle yield and lowered abdominal fat content. No further improvement in these parameters was recorded by increasing the level of replacement of NM with QPM to either 75% or 100%. Further, the improvement noticed in the 50% QPM group was similar to the group fed the NM diet with lysine supplementation, and thus dietary replacement of NM with QPM at 50% did not need extra synthetic lysine supplementation. It is concluded that dietary replacement of NM with QPM at the 50% level resulted in optimum performance, higher breast muscle yield and higher immune response in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Replacement of Normal Maize with Quality Protein Maize on Performance, Immune Response and Carcass Characteristics of Broiler Chickens

Panda¹,

Raju²,

Rao³

et al. 2010

Asian Australas. J. Anim. Sci

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“…Although the total EAA of T. emetica and T. dregeana were above those of chia, flax, and sunflower protein (Bautista et al ., 1996; Coelho & Salas‐Mellado, 2018; Nwachukwu & Aluko, 2018), like soy, they are below the FAO/WHO dietary recommendation for children (Table 3). Essential amino acids help in calcium absorption, boost muscle growth, and play an important role in collagen formation (Civitelli et al ., 1992; Bifari & Nisoli, 2017). Like soybean, Trichilia species protein concentrate had lower amino acids score for the EAA (Thr, Lys, Met, Val, Ile, Leu, Trp and Phe + Tyr) than the recommended FAO score for children (FAO/WHO, 2007) (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Influence of amino acid profile and secondary structure on nutritional and functional properties of Trichilia emetica and Trichilia dregeana protein concentrates

Tsomele

Plessis

Anyasi

et al. 2023

Int J of Food Sci Tech

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SummaryThe high prevalence of protein energy malnutrition (PEM) is a major concern in Africa. This problem could be resolved through the nutritional use of locally available underutilized tree seeds such as those from Trichilia species. This study determined and compared the amino acid profile, functional properties, and secondary structure of the proteins from Trichilia emetica and Trichilia dregeana oilseeds. The results showed that the essential amino acid levels of the two Trichilia seed proteins were above the recommended Food and Agricultural Organisation standard for adults, with essential‐to‐total (E/T) amino acid ratios (T. dregeana 52.8%; T. emetica 53.4%) and chemical scores of 100% for both species, which were not significantly different (P > 0.05) from those of soy proteins (53.0% and 100%, respectively). The amino acid profile results indicated that Trichilia oilseeds can serve as candidates for addressing protein malnutrition in economically disadvantaged communities of sub‐Saharan Africa. The secondary structure showed that the Trichilia oilseed proteins had significantly (P < 0.05) more β‐conformations compared to soybean proteins. Further, the functional properties suggested that Trichilia oilseed proteins can be used as ingredients in food and feed formulations due to their versatile functional properties.

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“…Supplements of arginine increase the synthesis of nitric oxide, which could increase vascularity and angiogenesis ( 32 ). Lastly, l-lysine could stimulate intestinal absorption and renal conservation of calcium, which is significantly associated with increased BMD ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Association between amino acids and recent osteoporotic fracture: a matched incident case-control study

Liang,

Shi,

Wang

et al. 2024

Front. Nutr.

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ContextOsteoporotic fracture is a major public health issue globally. Human research on the association between amino acids (AAs) and fracture is still lacking.ObjectiveTo examine the association between AAs and recent osteoporotic fractures.MethodsThis age and sex matched incident case-control study identified 44 recent x-ray confirmed fracture cases in the Second Hospital of Jilin University and 88 community-based healthy controls aged 50+ years. Plasma AAs were measured by high performance liquid chromatography coupled with mass spectrometry. After adjusting for covariates (i.e., body mass index, milk intake >1 time/week, falls and physical activity), we conducted conditional logistical regression models to test the association between AAs and fracture.ResultsAmong cases there were 23 (52.3%) hip fractures and 21 (47.7%) non-hip fractures. Total, essential, and non-essential AAs were significantly lower in cases than in controls. In the multivariable conditional logistic regression models, after adjusting for covariates, each standard deviation increase in the total (odds ratio [OR]: 0.304; 95% confidence interval [CI]: 0.117–0.794), essential (OR: 0.408; 95% CI: 0.181–0.923) and non-essential AAs (OR: 0.290; 95%CI: 0.107–0.782) was negatively associated with recent fracture. These inverse associations were mainly found for hip fracture, rather than non-hip fractures. Among these AAs, lysine, alanine, arginine, glutamine, histidine and piperamide showed the significantly negative associations with fracture.ConclusionThere was a negative relationship between AAs and recent osteoporotic fracture; such relationship appeared to be more obvious for hip fracture.

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Effect of L-lysine on cytosolic calcium homeostasis in cultured human normal fibroblasts

Cited by 8 publications

References 19 publications

Replacement of Normal Maize with Quality Protein Maize on Performance, Immune Response and Carcass Characteristics of Broiler Chickens

Replacement of Normal Maize with Quality Protein Maize on Performance, Immune Response and Carcass Characteristics of Broiler Chickens

Influence of amino acid profile and secondary structure on nutritional and functional properties of Trichilia emetica and Trichilia dregeana protein concentrates

Association between amino acids and recent osteoporotic fracture: a matched incident case-control study

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