Effect of lactic acid bacteria isolated from some fermented dairy products on carbon tetrachloride-induced hepatotoxicity and nephrotoxicity of albino rats

Bikheet, Maha; Mahmoud, Magda E.; Yassien, Eman; Hassan, Hanaa M.

doi:10.1007/s11356-021-16524-4

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…Incidence of NEP by CCL 4 leads to a higher level of both TBARS and NO in the renal tissue, and that was linked to the acidic media of CCL 4 that destruct the renal vascular endothelium and enhance the process of lipid peroxidation and biosynthesis of NO with huge amount [35]. The current information was concurred with [36,37].…”

Section: Discussionsupporting

confidence: 54%

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Madany,

El-Zeftawy,

Sanosi

et al. 2023

New Valley Veterinary Journal

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The kidney is an essential part of the urinary system responsible for hormone secretion and blood filtration from waste products. Nephrotoxicity (NEP) is one of the most popular kidney diseases and originates from environmental toxic agents and a wide spectrum of therapeutic drugs. Olive oil (OO) is among the natural oils extracted from olives. It offers many health benefits against chronic diseases and has an immunostimulant role. The study was designed to predict the reno-protective impact of OO opposing NEP. The research model was performed using three groups of adult male albino rats (n=30); the control group, NEP induced group by carbon tetrachloride, and the third group protected against NEP by OO. Kidney function was evaluated by measuring serum urea, creatinine, uric acid, and electrolytes. Further, the oxidative stress parameters, thiobarbituric acid reactive substances, nitric oxide, and reduced glutathione were analyzed in renal tissue homogenate. In addition, the ELISA technique assessed both tumor necrosis factor-alpha and interleukin-6. The histopathological study of renal tissue was also inspected. The results demonstrated that OO has an excellent protective effect, such as greatly restoring the higher level of kidney parameters and oxidative stress injury. Further, OO declined the induced inflammation and fibrosis in the protective group compared to NEP. Therefore, due to OO promising nephroprotective potentiality, it could be used to avoid disorders linked to oxidative stress. It is strongly recommended to conduct further research on its application.

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Section: Discussionsupporting

confidence: 54%

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Madany,

El-Zeftawy,

Sanosi

et al. 2023

New Valley Veterinary Journal

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“…This CCl 3 ∗ radical interacts with reactive oxygen species (ROS), leading to the generation of another radical known as trichloromethyl peroxyl radical (OOCCl 3 ∗). The presence of the two radicals CCl 3 ∗ and OOCCl 3 ∗ contributes to an increase in oxidative stress, triggering various pathways including lipid peroxidation ( Erdaş et al, 2021 ), disruption of the glutathione pathway ( Bikheet et al, 2022 ) and the production of pro-inflammatory cytokines, specifically TNF-α ( Devi et al, 2021 ) and IL-6 ( Wali et al, 2021 ). These cumulative effects ultimately contribute to liver damage.…”

Section: Discussionmentioning

confidence: 99%

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Bedoui,

Mufti,

Feriani

et al. 2024

Front. Pharmacol.

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In this current study, we explored the preventive capacity of the aqueous extract of Orobanche foetida (OF), a root holoparasite, against CCl4 prompt hepatotoxicity in rats. LC-MS/MS profiling revealed the existence of 32 compounds belonging to organic acids, benzoic acid derivatives, and hydroxycinnamic acids along with their glycosides and derivatives as well as several flavonoids. In vitro, OF demonstrated substantial antioxidant potential at DPPH and ABTS assays. Results showed that the pretreatment with OF for 6 weeks at the doses (25 mg/kg bw) and (50 mg/kg bw) countered the CCl4-induced liver injury by restoring liver injuries indicators (ALT, AST, LDH, ALP, GGT and bilirubin), normalizing lipid profile (TC, TG, LDL-C, and HDL-C), as well as, impeding DNA fragmentation. Furthermore, OF blocked the hepatic oxidative stress spurred by CCl4 administration through boosting antioxidant enzymes (GSH, CAT, and SOD) responsible of diminishing lipid peroxidation. exhibited an anti-inflammatory effect by downregulating TNF-α and IL-6 levels. OF suppressive effect on proinflammatory cytokines is further exerted by its capacity to modulate the expression of the NF-κB gene. In silico investigation revealed that among the 32 identified compounds, vanillic acid glucoside and dihydroxybenzoic acid glucoside have strong and stable bindings with the active sites of three key inflammatory proteins (PARP-1, TNF-α, IL-6), which could highlight the antioxidant and anti-inflammatory capacity of. Overall, this research provides a preliminary pharmacological support for the medicinal applications of Orobanche foetida for addressing inflammatory and hepato-pathological conditions.

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“…It has been studied that P. acidilactici can survive through the gastrointestinal tract, can survive drying, can be stored at 4 °C for 60 days [ 40 , 41 ], and is active against Helicobacter pylori in vitro [ 42 ]. It has been shown that P. acidilactici ameliorates liver fibrosis induced by carbon tetrachloride (CCl 4 ) [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Renoprotective Effect of Pediococcus acidilactici GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways

et al. 2022

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Acute kidney injury (AKI) describes a sudden loss of kidney function and is associated with a high mortality. Pediococcus acidilactici is a potent producer of bacteriocin and inhibits the growth of pathogens during fermentation and food storage; it has been used in the food industry for many years. In this study, the potential of P. acidilactici GKA4 (GKA4) to ameliorate AKI was investigated using a cisplatin-induced animal model. First, mice were given oral GKA4 for ten days and intraperitoneally injected with cisplatin on the seventh day to create an AKI mode. GKA4 attenuated renal histopathological alterations, serum biomarkers, the levels of inflammatory mediators, and lipid oxidation in cisplatin-induced nephrotoxicity. Moreover, GKA4 significantly decreased the expression of inflammation-related proteins and mitogen-activated protein kinase (MAPK) in kidney tissues. Eventually, GKA4 also increased the levels of related antioxidant enzymes and pathways. Consistently, sirtuin 1 (SIRT1) upregulated the level of autophagy-related proteins (LC3B, p62, and Beclin1). Further studies are needed to check our results and advance our knowledge of the mechanism whereby PI3K inhibition (wortmannin) reverses the effect of GKA4 on cisplatin-treated AKI. Taken together, GKA4 provides a therapeutic target with promising clinical potential after cisplatin treatment by reducing oxidative stress and inflammation via the MAPK, AMP-activated protein kinase (AMPK)/SIRT1/nuclear factor kappa B (NF-κB), and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) axes.

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Effect of lactic acid bacteria isolated from some fermented dairy products on carbon tetrachloride-induced hepatotoxicity and nephrotoxicity of albino rats

Cited by 7 publications

References 45 publications

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

Renoprotective Effect of Pediococcus acidilactici GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways

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