Effect of Lactobacillus plantarum KFY02 isolated from naturally fermented yogurt on the weight loss in mice with high-fat diet-induced obesity via PPAR-α/γ signaling pathway

Mu, Jianfei; Zhang, Jing; Zhou, Xianrong; Zalán, Zsolt; Hegyi, Ferenc; Takács, Krisztina; Ibrahim, Amel; Awad, Sameh; Du, Muying

doi:10.1016/j.jff.2020.104264

Cited by 24 publications

(20 citation statements)

References 61 publications

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“…Lactobacillus plantarum KFY02 could significantly reduce the level of serum cytokines IL-10 and IL-4, increase the levels of anti-inflammatory factors in obese mice induced by HFD, reduce inflammation and alleviate fat accumulation. 10 Jang et al 47 found that Lactobacillus brevis G-101 could markedly decrease the levels of pro-inflammatory factors in the intestine of mice with colitis and potentiate the immunocyte function of intestinal mucosa. The results of this study were consistent with the aforementioned findings.…”

Section: Food and Function Papermentioning

confidence: 99%

“…6 Recently, dietary supplementation of probiotics has gradually become a new therapy to alleviate obesity and lipid accumulation. For example, Mu et al 10 showed that Lactobacillus plantarum KFY02 markedly reduced adipose tissue lesions and liver damage in HFD-fed mice and regulated the level of serum pro-inflammatory factors, and the peroxisome proliferator-activated receptor gamma (PPAR-γ) signaling pathway improved obesity. Lv et al 11 found that the intervention of Lactobacillus paracasei FZU103 for 8 weeks markedly reduced the body weight and hypertrophy of epididymal adipose tissue cells in HFD-fed mice, alleviated the excessive accumulation of lipid droplets in the liver, and improved the blood lipid level and liver biochemical indexes, so as to alleviate the disorder of lipid metabolism in mice.…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

et al. 2022

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Section: Food and Function Papermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

et al. 2022

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“…Therefore, their levels in serum are important indicators that reflect the extent of an abnormal liver function. Studies have detected high levels of ALT, AST, and AKP in the serum of obese mice (Mu et al, 2020). The present study also obtained similar results.…”

Section: Discussionmentioning

confidence: 99%

“…The experiment lasted for 9 weeks. In 1-4 weeks, all groups except for the normal received a 45% HFD for obesity induction (Table 1 lists the chemical composition of the regular chow diet and high-fat diet) (Mu et al, 2020). From the fifth week, the positive control (L-Carnitine) and samples (LPFS and LPUFS) of the corresponding concentration were taken based on obesity induction.…”

Section: High-fat Diet-induced Obese Micementioning

confidence: 99%

“…Therefore, healthy functional fermented products can be developed using the lemon peel for fermentation. Studies have shown that lactic acid bacteria (LAB) administration has a fat‐reducing effect in mice (Mu et al, 2020). In addition, studies have shown that pear extract fermented by LAB has a fat lowering effect in rats (Chu & Kim, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Anti‐obesity effect of fermented lemon peel on high‐fat diet‐induced obese mice by modulating the inflammatory response

Pan

Tan

Long

et al. 2022

Journal of Food Biochemistry

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Inflammation is a characteristic of obesity. The rich compounds in lemon peel have anti‐inflammatory effects. This study examined whether fermented lemon peel can have an anti‐obesity effect on obese mice induced by a high‐fat diet (HFD) by regulating inflammation. The lemon peel fermentation supernatant (LPFS) could inhibit the weight gain of mice and improve the lesions of the liver and epididymal adipose tissue. In addition, LPFS regulates blood lipids, liver function, and inflammation‐related indicators in the serum of obese mice. LPFS plays a positive role in regulating the inflammation and obesity‐related genes in liver tissue and adipose tissue of obese mice. High‐performance liquid chromatography showed an increase in the contents of compounds with antioxidant or/and anti‐inflammatory effects and compounds with anti‐obesity effects. These results suggest that the LPFS could help reduce obesity in obese mice induced by an HFD by adjusting the balance of the inflammatory response. Practical applications Obesity often increases the risk of chronic diseases, and mild inflammation is a feature of obesity. Therefore, timely suppression of inflammation in the body can help control the occurrence of obesity. This study clarified the anti‐obesity effect of fermented lemon peel on a high‐fat diet (HFD)‐induced obese mice by regulating the body's inflammatory response and confirmed that fermentation improves the anti‐inflammatory activity of lemon peel. This study provides important references for future investigation, prophylaxis, and treatment of inflammation and obesity‐related diseases, as well as the advances in functional foods and fermented foods with anti‐inflammatory and anti‐obesity activities.

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Advances in the role and mechanism of lactic acid bacteria in treating obesity

Shen

Zhang

Yang

et al. 2022

Food Bioengineering

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Obesity and its related complications have become increasingly serious social problems that threaten people's lives. Lactic acid bacteria (LAB) have shown an effective influence on preventing obesity in animal experiments and human clinical trials, but its exact mechanism remains unclear. In this review, LAB and several of its metabolites are taken as the point of penetration. It is aimed to summarize the relationship between obesity and gut microbiota, the efficacy of LAB, and its potential mechanisms of preventing obesity and lipid metabolism. LAB intervention can regulate gut microbiota and improve intestinal permeability which is damaged by a high-fat diet or lipopolysaccharide. Besides this, some metabolites produced by LAB can be involved in regulating host lipid metabolism-related pathways. Short-chain fatty acids, linoleic acid, and gammaaminobutyric acid, taken as representatives here, can participate in the regulation through AMP-activated protein kinase or peroxisome proliferator-activated receptor pathway and bowel-brain axis. Therefore, the ingestion of LAB may become a potential adjunctive treatment for obesity in future.

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Effect of Lactobacillus plantarum KFY02 isolated from naturally fermented yogurt on the weight loss in mice with high-fat diet-induced obesity via PPAR-α/γ signaling pathway

Cited by 24 publications

References 61 publications

Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

Anti‐obesity effect of fermented lemon peel on high‐fat diet‐induced obese mice by modulating the inflammatory response

Advances in the role and mechanism of lactic acid bacteria in treating obesity

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