Effect of leave extract of Ocimum basilicum on deltamethrin induced nephrotoxicity and oxidative stress in albino rats

Abstract

Deltamethrin is a pyrethroid insecticide used extensively in pest control. On the other hand it showed different toxicity in mammalian animals. Basil or sweet basil (Ocimum basilicum) is a plant which showed many pharmacological effects. The present work studied the potential protective effect of Ocimum basilicum extract on deltamethrin-induced nephrotoxicity in albino rats. Treating animals with deltamethrin induced several histopathological alterations in the kidney. The renal tubules lost their characteristic appearance and their lining epithelial cells were degenerated. The glomeruli were atrophied and the renal blood vessels were dilated and congested. The intertubular spaces were infiltrated by inflammatory leucocytic cells. Marked elevation in serum creatinine and urea was recorded. Moreover, deltamethrin increased significantly the concentration of malondialdehyde (MDA) and decrease the activities of superoxide dismutase (SOD) and catalase (CAT) in renal tissue. Treating animals with deltamethrin and aqueous extract of basil led to an improvement in histological and biochemical alterations induced by deltamethrin. The biochemical results showed that creatinine and urea appeared within normal level. Reduction in the level of MDA (lipid peroxidation marker) and increase in the activities of SOD and CAT was recorded. It was concluded from this study that basil aqueous extract has a beneficial impact on deltamethrininduced nephrotoxicity in albino rats by its antioxidant effect.

Hepatoprotective Impact of Chlorella vulgaris Powder on Deltamethrin Intoxicated Rats

“…Antioxidant enzymes (SOD and CAT) are the first line of defense against free radical induced oxidative stress. Superoxide dismutase is used for catalytic dismutation of superoxide radicals to hydrogen peroxide, while catalase is responsible for the catalytic decomposition of hydrogen peroxide to oxygen and H 2 O [30]. Our results regarding the oxidative hepatic tissue damage in DLMinduced toxicity which manifested by a significant elevation in the liver tissue MDA concentration with reduction of tissue CAT and SOD when compared to the control group.…”

Protective Effects of Zinc as Antioxidant Against the Genotoxic Potential of Deltamethrin

“…This finding came in accordance with previous studies which reported that DM significantly decreased the antioxidant defense [9,15,28,29]. Also DM intoxication caused significant increase in NO concentration [ Table-2].…”

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

“…Ocimum basilicum, popular known as Basil or Sweet Basil, is a common herb that belongs to Lamiaceae family. Studies have shown many pharmacological effects in several diseases, with potent antioxidant, anti-aging, anticancer, antiviral, and antimicrobial properties (Sakr, Al-Amoudi, 2012). Studies have reported that rosmarinic acid (RA) is the most biologically active compound present in Basil related to this activities (Javanmardi et al, 2002;Lee, Scagel, 2009;Shiga et al, 2009).…”