Effect of left ventricular diastolic dysfunction on development of primary graft dysfunction after lung transplant

Abstract

Purpose of reviewPrimary graft dysfunction (PGD) is one of the most common complications after lung transplant and is associated with significant early and late morbidity and mortality. The cause of primary graft dysfunction is often multifactorial involving patient, donor, and operational factors. Diastolic dysfunction is increasingly recognized as an important risk factor for development of PGD after lung transplant and here we examine recent evidence on the topic.Recent findingsPatients with end-stage lung disease are more likely to suffer from cardiovascular disease including diastolic dysfunction. PGD as result of ischemia–reperfusion injury after lung transplant is exacerbated by increased left atrial pressure and pulmonary venous congestion impacted by diastolic dysfunction. Recent studies on relationship between diastolic dysfunction and PGD after lung transplant show that patients with diastolic dysfunction are more likely to develop PGD with worse survival outcome and complicated hospital course.SummaryPatients with diastolic dysfunction is more likely to suffer from PGD after lung transplant. From the lung transplant candidate selection to perioperative and posttransplant care, thorough evaluation and documentation diastolic dysfunction to guide patient care are imperative.

Association between preoperative diastolic dysfunction and early allograft dysfunction after orthotopic liver transplantation: An observational study

“…observed a stepwise increase in major adverse cardiac events (MACE) risk with worsening DD grade on a cohort of 234 patients undergoing kidney transplantation and assessed for the clinical risk of complications using the AHA/ACCF consensus statement on the assessment of kidney transplant candidates 17 . Yoon and Salamanca‐Padilla published a review analyzing the effects of the left ventricular DD in lung transplant patients 22 . The authors highlighted how patients affected by DD are at a higher risk to develop primary graft dysfunction after lung transplantation 22 .…”

“…22 The authors emphasize that the assessment of DD might be mandatory in the preoperative assessment of lung transplant patients. 22 In the specific area of liver transplantation, Carvalheiro et al analyzed the data relative to 106 patients undergoing liver transplantation. 23 They found a statistically significant correlation between the presence of DD according to the ASE/EACVI guidelines from 2009 and 90-day mortality.…”

“…22 The authors highlighted how patients affected by DD are at a higher risk to develop primary graft dysfunction after lung transplantation. 22 The authors emphasize that the assessment of DD might be mandatory in the preoperative assessment of lung transplant patients. 22 In the specific area of liver transplantation, Carvalheiro et al analyzed the data relative to 106 patients undergoing liver transplantation.…”

“…Yoon and Salamanca‐Padilla published a review analyzing the effects of the left ventricular DD in lung transplant patients 22 . The authors highlighted how patients affected by DD are at a higher risk to develop primary graft dysfunction after lung transplantation 22 . The authors emphasize that the assessment of DD might be mandatory in the preoperative assessment of lung transplant patients 22 .…”

Assessing the nitric oxide efficacy in bilateral lung transplantation

“…1 представлена общая характеристика пациентов, включенных в исследование. чаев приводит к смертельному исходу в первый месяц после оперативного вмешательства [1][2][3][4].…”