We have read with interest the recent article by Werneck et al. (1) regarding the prospective associations of leisure-time physical activity (LTPA) with psychological distress and well-being. The authors reported that there is an association of higher LTPA intensity and frequency with low psychological distress and increased psychological well-being and that the body mass index (BMI) partially mediates this association. The results of this study offer some novel insights; however, we would like to draw attention to some additional points worth consideration.Although the authors have adjusted for several covariates at baseline (34 years), the effect of other variables like family activities, social participation, and social support, Self-esteem, life skills, friends and social behavior, self-perceived skills, and emotional support is not examined. Many of these variables were recorded during earlier follow-ups of the cohort (2). Studies have reported the associations of these confounding variables with LTPA and psychological distress and well-being (3,4). Thereby, not adjusting them can influence the outcome. In addition, the reverse causation of psychological well-being and distress remains a concern, given that the psychological correlates may discourage people from engaging in physical activities, which cannot be ruled out in the present analysis.The authors analyzed mediators as a secondary aim, but the selection of cognition, BMI, disability, and pain is not substantiated theoretically. Existing literature suggests that these variables can influence the level of physical activity and psychological wellbeing. Therefore, the possibility of these variables as confounders cannot be ruled out, especially in the absence of baseline data for these variables. There is a possibility that BMI and cognition can influence the level of physical activities, and having their baseline assessment could have provided clarity regarding change over time. The basic assumption for the mediation model is a casual chain of effect, where one variable affects the later occurring variable (no reverse causality) (5). In addition, while using longitudinal mediation analysis, the reason for choosing the three specific time points in the cohort is not explained. Consistency of LTPA over different time points is also not reported, which could have substantiated the findings (6). Moreover, for cognition, the only verbal recall was measured and the reason for the same is unexplained. It is unlikely that verbal recall can represent global cognition.Examining the mediators for the effect of physical activity on psychological well-being is an important domain for future research, and a robust mediation model can address these issues for clear interpretation of findings.