Effect of Levodopa + Carbidopa on the Laryngeal Electromyographic Pattern in Parkinson Disease

Noffs, Gustavo; Duprat, André de Campos; Zarzur, Ana Paula; Cury, Rubens Gisbert; Cataldo, B.; Fonoff, Erich Talamoni

doi:10.1016/j.jvoice.2016.09.001

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Furthermore, f 0 modulations were not affected by levodopa intake, which is in line with the previous literature [ 24 , 25 , 26 , 29 ]. Although the control over the glottal speech system does not improve, increased intensity values were measured in the med-ON condition, indicating an improved subglottal pressure, as already investigated by Ho and colleagues [ 31 ].…”

Section: Discussionsupporting

confidence: 92%

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Levodopa-Based Changes on Vocalic Speech Movements during Prosodic Prominence Marking

et al. 2021

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The present study investigates speech changes in Parkinson’s disease on the acoustic and articulatory level with respect to prosodic prominence marking. To display movements of the underlying articulators, speech data from 16 patients with Parkinson’s disease were recorded using electromagnetic articulography. Speech tasks focused on strategies of prominence marking. Patients’ ability to encode prominence in the laryngeal and supra-laryngeal domain is tested in two conditions to examine the influence of motor performance on speech production further: without dopaminergic medication and with dopaminergic medication. The data reveal that patients with Parkinson’s disease are able to highlight important information in both conditions. They maintain prominence relations across- and within-accentuation by adjusting prosodic markers, such as vowel duration and pitch modulation, while the acoustic vowel space remains the same. For differentiating across-accentuation, not only intensity but also all temporal and spatial parameters related to the articulatory tongue body movements during the production of vowels are modulated to signal prominence. In response to the levodopa intake, gross motor performance improved significantly by 42%. The improvement in gross motor performance was accompanied by an improvement in speech motor performance in terms of louder speech and shorter, larger and faster tongue body movements. The tongue body is more agile under levodopa increase, a fact that is not necessarily detectable on the acoustic level but important for speech therapy.

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Section: Discussionsupporting

confidence: 92%

“…Studies recording sustained vowel phonation found that glottal control increases [ 24 ] but most often stayed unchanged [ 25 , 26 , 27 , 28 , 29 , 30 ] when comparing medication-OFF and medication-ON conditions. Moreover, many studies describe changes in speech rate with levodopa intake [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Levodopa-Based Changes on Vocalic Speech Movements during Prosodic Prominence Marking

et al. 2021

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“…For all patients, we collected demographic data (sex and age), clinical data including motor symptoms, non-motor symptoms, age of onset of PD, disease duration, tremor location, tremor pattern, past medical history, family history, medication history, and anti-tremor drug responsiveness. The Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn & Yahr (H&Y) scale in an "off " phase (>12 h after the last dose of dopaminergic medication; >24 h after anticholinergics or β-blockers) were evaluated for the t-PD and ET-PD groups (14).…”

Section: Patientsmentioning

confidence: 99%

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

et al. 2020

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Background and Objective: Parkinson's disease developed from essential tremor (ET-PD) is a distinct clinical syndrome that is different from essential tremor (ET) and Parkinson's disease (PD). There is currently a lack of research on ET-PD. Tremor characteristics (amplitude and frequency) are primary quantitative indexes for diagnosing and monitoring of tremors. In this study, we aimed to explore specific clinical and electrophysiological biomarkers for the identification of ET-PD. Methods:The study included patients with ET-PD (n = 22), ET (n = 42), and tremor-dominant PD (t-PD, n = 47). We collected demographic data, clinical characteristics (including motor and non-motor symptoms), and tremor analysis. The frequency, amplitude, contracting patterns of resting tremor and postural tremor were collected. The analysis of ET-PD and ET/t-PD was compared. The receiver operating characteristic (ROC) curve was used to analyze the electrophysiological features in distinguishing ET-PD from ET or t-PD.Results: Compared with ET, hyposmia, bradykinesia, rigidity, postural abnormality, and resting tremor were more common in the ET-PD group (P = 0.01, 0.003, 0.001, 0.001, 0.019, respectively). The postural tremor frequencies of the head, upper limbs, and lower limbs were significantly lower in the ET-PD than in the ET (P = 0.007, 0.003, 0.035, respectively), which were the most appropriate variables for distinguishing ET-PD from ET (AUC: 0.775, 0.727, and 0.701, respectively). Compared with t-PD, bradykinesia, rigidity, postural abnormality (both P < 0.001), and resting tremor (P = 0.024) were less common in the ET-PD. The postural tremor amplitudes of the head and upper limbs were significantly higher in the ET-PD than in the t-PD (P = 0.022, 0.001, respectively), which were the most appropriate variables for distinguishing ET-PD from t-PD (AUC: 0.793 and 0.716). Conclusions:Hyposmia and electrophysiological biomarkers (postural tremor frequencies and amplitudes) help early recognition of ET-PD.

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Voice changes in Parkinson’s disease: What are they telling us?

Lau

Thyagarajan

2020

Journal of Clinical Neuroscience

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Effect of Levodopa + Carbidopa on the Laryngeal Electromyographic Pattern in Parkinson Disease

Cited by 4 publications

References 30 publications

Levodopa-Based Changes on Vocalic Speech Movements during Prosodic Prominence Marking

Levodopa-Based Changes on Vocalic Speech Movements during Prosodic Prominence Marking

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

Voice changes in Parkinson’s disease: What are they telling us?

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