Effect of levosimendan, an inodilator, on streptozotocin-induced diabetic nephropathy in rats

Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

“…Other compounds with antioxidant potential have demonstrated nephroprotective effects in experimental models of diabetes, both of natural [ 33 ] and pharmacological [ 34 ] origin. This antioxidant potential is of fundamental importance in explaining the nephroprotection of hydroxytyrosol at a morphological and functional level.…”

Levosimendan ameliorates the scopolamine induced cognitive impairment via modulating pCREB/BDNF expression, cholinergic neurotransmission and neuroinflammation

“…Levosimendan, a positive inotropic drug approved to increase cardiac contractility and management of decompensated heart failure. Indeed, earlier research has reported the ability of levosimendan against Parkinson's disease [12], mild septic encephalopathy [13], ototoxicity [14], nephrotoxicity [15], tauoligomerisation inhibition in brain cells of Tau P301L -BiFC mice [16] and other attributes include anti-oxidant and anti-in ammatory effects [17][18][19]. The cardioprotective effects and vasodilatory actions Levosimendan are mediated by calcium sensitization of contractile proteins and opening of ATPdependent K + channels in vascular smooth muscle cells and cardiac mitochondria [20][21][22][23][24].…”