Effect of light/dark regimen on N-nitrosoethylurea-induced transplacental carcinogenesis in rats

Бениашвили, Д Ш; Benjamin, Shalva; Baturin, Dmitri A.; Anisimov, Vladimir N.

doi:10.1016/s0304-3835(00)00673-x

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…In addition, studies in animal models have supported the inference that melatonin has physiological antitumor activity (14,15). Blask et al (54,55) provided experimental evidence that light exposure during darkness increases the risk of cancer progression via elimination of the nocturnal melatonin signal and its suppression of tumor fatty acid metabolism.…”

Section: Discussionmentioning

confidence: 98%

“…Animal studies have shown compelling evidence that constant exposure to light significantly promotes transplacental carcinogenesis (14). Furthermore, melatonin has been shown to be a free-radical scavenger and antioxidant, and conditions that involve free-radical damage may be aggravated by light-mediated suppression of melatonin levels (15).…”

Section: Elatonin N-acetyl-5-methoxytryptaminementioning

confidence: 99%

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Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work

Kayumov

Casper

Hawa

et al. 2005

The Journal of Clinical Endocrinology & Metabolism

129

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Decreases in melatonin production in human and animals are known to be caused by environmental lighting, especially short-wavelength lighting (between 470 and 525 nm). We investigated the novel hypothesis that the use of goggles with selective exclusion of all wavelengths less than 530 nm could prevent the suppression of melatonin in bright-light conditions during a simulated shift-work experiment. Salivary melatonin levels were measured under dim (<5 lux), bright (800 lux), and filtered (800 lux) light at hourly intervals between 2000 and 0800 h in 11 healthy young males and eight females (mean age, 24.7 +/- 4.6 yr). The measurements were performed during three nonconsecutive nights over a 2-wk period. Subjective sleepiness was measured by self-report scales, whereas objective performance was assessed with the Continuous Performance Test. All subjects demonstrated preserved melatonin levels in filtered light similar to their dim-light secretion profile. Unfiltered bright light drastically suppressed melatonin production. Normalization of endogenous melatonin production while wearing goggles did not impair measures of performance, subjective sleepiness, or alertness.

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Section: Discussionmentioning

confidence: 98%

Section: Elatonin N-acetyl-5-methoxytryptaminementioning

confidence: 99%

Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work

Kayumov

Casper

Hawa

et al. 2005

The Journal of Clinical Endocrinology & Metabolism

129

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“…Investigation of light effects on mammary tumorigenesis in rodents began in the 1960s . For both chemically induced and spontaneous tumors, most of these studies showed an increase in tumor incidence and number by exposure to a constantly lighted environment compared with a 24‐hour alternating schedule of light and dark (eg, 24 hours of light vs 12 hours of light:12 hours of dark).…”

Section: Animal Models Of Light and Cancermentioning

confidence: 99%

Breast cancer and circadian disruption from electric lighting in the modern world

Stevens

Brainard²,

Blask

et al. 2013

CA A Cancer J Clinicians

275

201

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Breast cancer is the leading cause of cancer death among women worldwide and there is only limited explanation of why. Risk is highest in the most industrialized countries but also rising rapidly in the developing world. Known risk factors account for only a portion of the incidence in the high risk populations, and there has been considerable speculation, and many false leads, on other possibly major determinants of risk such as dietary fat. A hallmark of industrialization is the increasing use of electricity to light the night, both within the home and without. It has only recently become clear that this evolutionarily new, and thereby unnatural exposure can disrupt human circadian rhythmicity, of which three salient features are melatonin production, sleep, and the circadian clock. A convergence of research in cells, rodents, and humans suggests that the health consequences of circadian disruption may be substantial. An innovative experimental model has shown that light at night markedly increases growth of human breast cancer xenografts in rats. In humans, the theory that light exposure at night increases breast cancer risk leads to specific predictions that are being tested epidemiologically: evidence has accumulated on risk in shift workers, risk in blind women, and impact of sleep duration on risk. If electric light at night does explain a portion of the breast cancer burden then there are practical interventions that can be implemented, including more selective use of light, and adoption of recent advances in lighting technology and application.

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“…Observational studies have associated night-shift work with an increased risk of breast and colorectal cancers (Davis et al, 2001;Hansen, 2001;Schernhammer et al, 2003). Animal studies have shown that constant exposure to light significantly promotes transplacental carcinogenesis (Beniashvili et al, 2001). Furthermore, melatonin has been shown to be a freeradical scavenger and antioxidant, and conditions that involve free-radical damage may be aggravated by light suppression of melatonin levels (Reiter, 2002).…”

Section: Introductionmentioning

confidence: 99%

Prevention of melatonin suppression by nocturnal lighting: relevance to cancer

Kayumov

Lowe²,

Rahman³

et al. 2007

European Journal of Cancer Prevention

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The decreased melatonin production in humans and animals caused by environmental lighting, especially short wavelength lighting (between 470 and 525 nm) has been shown to be associated with an increased risk of cancer. The purpose of this study was to investigate whether blocking light in this wavelength range under bright light may prevent the suppression of melatonin, which could help to prevent cancer. Optical filter lenses were designed, allowing selective exclusion of all wavelengths below 530 nm. Salivary melatonin levels were measured under dim light (<5 lux), bright light (800 lux) and filtered light (800 lux) at hourly intervals between 2000 and 0800 h in 11 healthy young male participants (mean age 23.5+/-1.5 years). The measurements were taken during three nonconsecutive nights over a 2-week period. The Dim Light Melatonin Onset test was used as a marker of circadian phase. Nine of the 11 participants demonstrated preserved melatonin levels in filtered light similar to their dim light secretion profile. With filtered light, the participants had a mean relative amount of melatonin of 91.2 (P>0.05 between dim light and experimental condition). Unfiltered bright light drastically suppressed melatonin production with a mean relative amount of melatonin of 25.4 (P<0.05 between dim light and experimental condition). Preventing melatonin deficiencies using lenses that block light of low wavelength from reaching the retina presents a cost-effective, practical solution to the problem of increased malignancy rates in shift workers.

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Effect of light/dark regimen on N-nitrosoethylurea-induced transplacental carcinogenesis in rats

Cited by 11 publications

References 26 publications

Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work

Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work

Breast cancer and circadian disruption from electric lighting in the modern world

Prevention of melatonin suppression by nocturnal lighting: relevance to cancer

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