Effect of lignin-derived lignophenols on vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats

Mukai, Yuuka; Norikura, Toshio; Fujita, Shuzo; Mikame, Keigo; Funaoka, Masamitsu; Sato, Shin

doi:10.1007/s11010-010-0645-9

Cited by 19 publications

(8 citation statements)

References 32 publications

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“…11 Lignophenol (LP), which is a derivative of lignin, reduced plasma cholesterol and triglycerides in streptozotocin-induced diabetic rats. 12 In addition, LP supplementation in HFD-fed rats showed reduced plasma triglycerides and epididymal fat tissue weights. 13 The phenolic fragments of Kraft lignin, obtained as a byproduct during cellulose (CEL) extraction in the paper manufacturing process, are potential antioxidants, comparable to vitamin E in humans.…”

Section: ■ Introductionmentioning

confidence: 98%

“…Several studies reported that plant polyphenols reduce plasma triglycerides and total cholesterol in high-fat diet (HFD)-induced obese animals . Lignophenol (LP), which is a derivative of lignin, reduced plasma cholesterol and triglycerides in streptozotocin-induced diabetic rats . In addition, LP supplementation in HFD-fed rats showed reduced plasma triglycerides and epididymal fat tissue weights .…”

Section: Introductionmentioning

confidence: 99%

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Hypocholesterolemic Effect of the Lignin-Rich Insoluble Residue of Brewer’s Spent Grain in Mice Fed a High-Fat Diet

Raza

Maukonen

Mäkinen

et al. 2018

J. Agric. Food Chem.

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Insoluble residue (INS) is a lignin-rich fraction of brewer's spent grain (BSG) that also contains β-glucan and arabinoxylan, the major constituents of dietary fiber. We investigated the effects of INS in diet-induced obese mice in terms of lipid metabolism and metabolic diseases. Male mice (C57bl6) were fed a high-fat diet (HFD), a HFD + 20% INS, a HFD + 20% cellulose (CEL), a HFD with a combination of 20% INS−CEL (1:1), or a control diet for 14 weeks. Insulin and glucose tolerance tests were performed after 12 weeks. Fasting plasma lipids, bile acid, and fecal bile acid were measured after 14 weeks of feeding, and tissues were collected for gene expression analysis. Body weight gain was significantly reduced with all fibers, but only INS and INS−CEL decreased fasting plasma low-density lipoprotein cholesterol and total cholesterol compared to HFD. CEL and INS−CEL significantly improved insulin resistance. Fecal bile acids were significantly increased by all fibers, but there was no change in plasma bile acid. Clostridium leptum was increased with all fibers, but universal bacterial diversity was only with INS and INS−CEL. In addition, INS significantly increased the abundance of Bacteriodes, while CEL decreased Atopobium and Lactobacillus. INS feeding significantly upregulated various genes of cholesterol and bile acid metabolism, such as Srebp2, Hmgcr, Ldlr, Cyp7a1, Pparα, Fxr, and Pxr, in the liver. INS, INS−CEL, and CEL significantly attenuated liver steatosis. Our results suggest that INS from BSG induced beneficial systemic changes in mice via gut microbiota, bile acids, and gene expression in the liver.

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Section: ■ Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic Effect of the Lignin-Rich Insoluble Residue of Brewer’s Spent Grain in Mice Fed a High-Fat Diet

Raza

Maukonen

Mäkinen

et al. 2018

J. Agric. Food Chem.

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“…Overexpression of iNOS was detected in DB rats, results that agree with previous reports. 60,61 Interestingly, iNOS mRNA levels tended to decrease after RWPS intake, probably due to the antiinflammatory and antioxidant bioactivities of its polyphenols 62,63 and the anti-inflammatory response associated to increased dietary fiber intake and SCFA production. 43 With regard to eNOS, reduced activity and/or expression of this constitutive NO generating enzyme have been proposed among causes that potentiate the diabetes-impaired NO biavailability, 9,10 but its transcriptional and post-transcriptional modulation under hyperglycemia is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of oxidative stress in Type 1 diabetic rats supplemented with a seasoning obtained from winemaking by-products and its effect on endothelial function

et al. 2016

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Type 1 diabetes mellitus (DM) is characterized by hyperglycemia resulting from insulin deficiency. This is usually accompanied by a pro-oxidative environment, dyslipidemia and endothelial dysfunction, thus leading to several micro- and macro-vascular complications. This study investigated the potential benefits of a seasoning obtained from seedless red wine pomace (RWPS) in protecting against oxidative damage and preserving endothelial function in Type 1 DM, and the underlying mechanisms involved at the level of gene expression. The diet of streptozotocin (45 mg kg)-induced diabetic (DB) and control (CN) male Wistar rats (n = 5 rats per group) was supplemented with RWPS (300 mg per kg per day) or vehicle for 4 weeks. Characteristic indicators of DM such as increased food and water intakes and weight loss were significantly ameliorated in DB + RWPS rats, with a notable normalization in their fasting glycemic control and cholesterol profile. Plasma total antioxidant capacity (TAC) was substantially increased, and biomarkers of oxidative damage to lipids (F-isoprostanes, 24.9%; malondialdehyde, 28.4%) and proteins (carbonyl groups, 5.91%) were significantly decreased. Nitric oxide availability tended to improve in plasma of DB + RWPS compared with DB rats. Insulin levels were increased (1.51-fold) and aortic tissue antioxidant enzymes such as mitochondrial superoxide dismutase (SOD2, 1.93-fold) were up-regulated. Other important genes for endothelial function, including endothelial β-nicotinamide adenine dinucleotide phosphate oxidase (NOX4), endothelial and inducible nitric oxide synthases (eNOS, iNOS), and angiotensin-converting enzyme-I (ACE), were non-significantly modulated, although certain potentially positive trends were observed. These results indicate that RWPS supplementation might be a useful nutritional approach to manage Type 1 DM and ameliorate its vascular complications.

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“…LPs-containing diets were proved to be very helpful for lowering plasma triglyceride levels in rats fed a high-fat diet by potentially suppressing the expression of sterol regulatory element-binding protein (SREBP) and acetyl-CoA carboxylase (ACC) (Sato et al, 2012). Mukai et al (2011) also investigated the effects of lignin-derived LPs on diabetic rats, and their findings suggested that LPs alleviated vascular oxidative stress by inhibiting the expression of nicotinamide adenine dinucleotide (phosphate) (NAD(p)H) oxidase. Apart from the potential in diabetes control, Suzuki et al (1990) found that LPs extracted from Lentinus edodes (an edible mushroom) have potent antiviral activity against human immunodeficiency virus (HIV) on the basis of the assay for the proliferation of mouse bone marrow cells.…”

Section: Lignin-based Polymers/lignophenolsmentioning

confidence: 99%

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

et al. 2022

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Lignin is identified as a promising candidate in renewable energy and bioproduct manufacturing due to its high abundance, polymeric structure, and biochemical properties of monomers. Thus, emerging opportunities exist in generating high-value small molecules from lignin through depolymerization. This review aims at providing an overview of the major technologies of lignin depolymerization. The feasibility of large-scale implementation of these technologies, including thermal, biological, and chemical depolymerizations, are discussed in relation to potential industrial applications. Lignin as a renewable alternative to petroleum-based chemicals has been well documented. This review attempts to emphasize potential applications of lignin-derived monomers and their derivatives as bioactives in food, natural health product, and pharmaceutical sectors. The critical review of the prospects and challenges of lignin-derived bioproducts reveals that the advancement of research and development is required to explore the applications of depolymerization of lignins to their full potential.

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Effect of lignin-derived lignophenols on vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats

Cited by 19 publications

References 32 publications

Hypocholesterolemic Effect of the Lignin-Rich Insoluble Residue of Brewer’s Spent Grain in Mice Fed a High-Fat Diet

Hypocholesterolemic Effect of the Lignin-Rich Insoluble Residue of Brewer’s Spent Grain in Mice Fed a High-Fat Diet

Attenuation of oxidative stress in Type 1 diabetic rats supplemented with a seasoning obtained from winemaking by-products and its effect on endothelial function

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

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