Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity

Edible and medicinal fungi breeding techniques, a review: Current status and future prospects

“…Chemical mutagens are potent as effective radiations in bringing about genetic changes ( Hussain et al, 2020 ). Chemical mutagenesis generates a broad spectrum of mutant alleles ( Sarin, Prabhu, O'Meara, Pe'er, & Hobert, 2008 ), ( Haelterman et al, 2014 ) such as gain-of-function, temperature-sensitive, and null alleles ( Talih et al, 2020 ). Chemical agents could mainly cause cell damage, lethality, and genetic injury; different concentrations between the test agent in the medium and around the genome; complex induction or suppression by chemical agents in cellular repair systems, and the accessibility of different regions of the genome were different for the sequestration effects etc.…”