Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery

Paliwal, Rishi; Rai, Shivani; Vaidya, Bhuvaneshwar; Khatri, Kapil; Goyal, Amit K.; Mishra, Neeraj; Mehta, Abhinav; Vyas, Sameer

doi:10.1016/j.nano.2008.08.003

Cited by 247 publications

(132 citation statements)

References 27 publications

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“…Usually, the enteric drug delivery vehicles show a CPDR of less than 10% in gastric pH (pH 1.2). [26] The release studies suggested that the release of C3 hydrogels was below 10% up to 180 min, which is much longer than the reported literature.…”

Section: Drug Release Studymentioning

confidence: 70%

Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

Shaw

Uvanesh

Gautham

et al. 2015

Designed Monomers and Polymers

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The purpose of this research was to synthesize and characterize gelatin and tamarind gum (TG)/carboxymethyl tamarind (CMT) gum-based phase-separated hydrogels. The hydrogels were thoroughly characterized using bright-field microscope, FTIR spectroscope, differential scanning calorimeter, mechanical tester, and impedance analyzer. The mucoadhesivity, biocompatibility, and swelling property of the hydrogels were also evaluated. The antimicrobial efficiency of ciprofloxacin (model antimicrobial drug) loaded hydrogels was studied against E. coli. The in vitro drug release was carried out in both gastric and intestinal pHs. Microstructural analysis suggested the formation of phase-separated hydrogels. FTIR studies suggested that CMT gum altered the secondary structure of the gelatin molecules. Presence of the polysaccharides within the hydrogels resulted in the increase in the enthalpy and entropy for evaporation of the moisture from the hydrogels. The mechanical studies indicated viscoelastic nature of the hydrogels. Electrical analysis suggested an increase in the impedance of the hydrogels in the presence of the TG. The presence of CMT gum resulted in the decrease in the impedance of the hydrogels. The hydrogels exhibited good mucoadhesivity, biocompatibility, and pH-dependent swelling behavior. The drug-loaded hydrogels showed good antimicrobial activity and the drug release from the hydrogels was pH dependent and diffusion mediated.

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Section: Drug Release Studymentioning

confidence: 70%

Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

Shaw

Uvanesh

Gautham

et al. 2015

Designed Monomers and Polymers

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“…SLN dispersion was centrifuged at 12000 rpm for 30 min so as to settle the SLN pellet. 1 ml of supernatant was dissolved in 10 ml of methanol, the solution was filtered and amount of free drug in the supernatant was determined by measuring absorbance at 270 nm in UV spectrophotometer (UV 1700, Shimadzu AS, Japan) [15]. %EE was calculated from the following equation:…”

Section: Determination Of Entrapment Efficiencymentioning

confidence: 99%

A Quality by Design Concept on Lipid Based Nanoformulation Containing Antipsychotic Drug: Screening Design and Optimization using Response Surface Methodology

Patel¹,

Sawant²

2017

J Nanomed Nanotechnol

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“…These mechanisms include the general adhesiveness of nanoparticles and the absorption-enhancing effect of lipids. 19 Paliwal et al reported that SLNs-based drug delivery showed a many-fold increase in methotrexate concentration in the lymphatic region compared with standard methotrexate solution administration, 20 which indicates improved intestinal lymphatic transportation of drugs incorporated into SLNs. The lectin in Pue-SLNs enhances lymph formation and thus increases the lymphatic flow rate.…”

Section: Introductionmentioning

confidence: 99%

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles

Luo¹,

Hou²,

Jun³

et al. 2013

IJN

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Puerarin has multiple pharmacological effects and is widely prescribed for patients with cardiovascular diseases including hypertension, cerebral ischemia, myocardial ischemia, diabetes mellitus, and arteriosclerosis. We have successfully prepared puerarin-loaded solid lipid nanoparticles (Pue-SLNs) for oral administration. Pue-SLNs are prepared using monostearin, soya lecithin, and poloxamer 188. SLNs may alter the course of puerarin absorption predominantly to and through lymphatic routes and regions, presumably following a transcellular path of lipid absorption, especially by enterocytes and polar epithelial cells of the intestine. The alteration of absorption might influence the metabolic profile of puerarin when incorporated into SLNs. In the present study, we investigated the metabolic profile of puerarin in rat plasma and urine using rapid resolution liquid chromatography-tandem mass spectrometry after a single-dose intragastric administration of Pue-SLNs in comparison with puerarin suspension. Two glucuronidated metabolites of puerarin, puerarin-4′-O-glucuronide and puerarin-7-Oglucuronide, were detected in rat plasma and urine after intragastric administration of Pue-SLNs, with the latter acting as the major metabolite. Similar results were found in rat plasma and urine after intragastric administration of puerarin suspension. The results suggest that incorporation of puerarin into SLNs does not change either the position of glucuronidation or the metabolic pathway of puerarin in rats.

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Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery

Cited by 247 publications

References 27 publications

Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

Development and characterization of gelatin-tamarind gum/carboxymethyl tamarind gum based phase-separated hydrogels: a comparative study

A Quality by Design Concept on Lipid Based Nanoformulation Containing Antipsychotic Drug: Screening Design and Optimization using Response Surface Methodology

Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles

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