Effect of Lipidic Excipients on the Particle Properties and Aerosol Performance of High Drug Load Spray Dried Particles for Inhalation

Shetty, Nivedita; Hou, Jonathan; Yanez, Evelyn; Shur, Jagdeep; Cheng, Joan; Sun, Changquan Calvin; Nagapudi, Karthik; Narang, Ajit S.

doi:10.1016/j.xphs.2021.09.004

Cited by 7 publications

(3 citation statements)

References 31 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, part of the MF must not have been loaded on the phospholipid microparticles, and the aerosol performance of free micronized MF might be different from that of the loaded MF. Previous studies on co-suspension have adsorbed multiple drugs on the surface of carrier microparticles simultaneously, which makes it difficult to show the difference in aerodynamic performance between the micronized drug and carrier microparticles and to evaluate the degree of drug-loading by the carrier ( Doty et al, 2017 ; Shetty et al, 2021 ). Therefore, in our co-suspension study, a low dosage of water-soluble FF was added with DSPC to prepare the carrier, namely lip/FF-microparticles.…”

Section: Discussionmentioning

confidence: 99%

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Miao

Cao

et al. 2023

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Miao

Cao

et al. 2023

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

“…This is because solid phase properties have substantial effects on the long-term stability of such powders and can also point to instability during storage (Edueng et al, 2019). The methodology most frequently used to assess these properties for spray-dried powders is powder X-ray diffraction (PXRD), which gives crystallinity information for the bulk powder (Bianco et al, 2012;Lu et al, 2019;Shetty et al, 2022). Microcrystals in the samples cause diffraction of an incident X-ray, translating into peaks in the obtained diffractograms that can be used to determine the crystal structure of the known material inside the powder (Brittain, 2003).…”

Section: Sem Him/fibmentioning

confidence: 99%

Mechanistic Formulation Design of Spray-Dried Powders

Ordoubadi

Wang

Vehring

2023

KONA

View full text Add to dashboard Cite

Spray drying is gaining traction in the pharmaceutical industry as one of the processing methods of choice for the manufacture of solid dosage forms intended for pulmonary, oral, and parenteral delivery. This process is particularly advantageous because of its ability to produce engineered particles with improved efficacy and stability by combining active pharmaceutical ingredients or biologics with appropriate excipients. Moreover, due to its high throughput, continuous operation, and ability to produce thermostable solid powders, spray drying can be a manufacturing method of choice in the production of drugs and other formulations, including vaccines, for global distribution. Formulation design based on a mechanistic understanding of the different phenomena that occur during the spray drying of powders is complicated and can therefore make the use of available particle formation models difficult for the practitioner. This review aims to provide step-by-step guidance accompanied by critical background information for the successful formulation design of spray-dried microparticles. These include discussion of the tools needed to estimate the surface concentration of each solute during droplet drying, their times and modes of solidification, and the amount of glass stabilizers and shell formers required to produce stable and dispersible powders.

show abstract

“…Spray drying of solutions of GDC-A dissolved in an 80/20 w/w mixture of dichloromethane and methanol with DSPC as a shellforming excipient (GDC-A/DSPC = 9/1 mol/mol) resulted in production of an amorphous solid (Shetty et al, 2021). When exposed to a temperature of 40 °C for a period of just 24 h, the amorphous solid partially recrystallized to Form E (16.3% w/w).…”

Section: Improved Physical and Chemical Stabilitymentioning

confidence: 99%

Formulation of Dry Powders for Inhalation Comprising High Doses of a Poorly Soluble Hydrophobic Drug

Tarara¹,

Miller²,

Weers³

et al. 2022

Front. Drug. Deliv.

View full text Add to dashboard Cite

Spray-dried formulations of a hydrophobic, crystalline drug, GDC-A, were prepared using the suspension-PulmoSphere™ technology. Increases in drug loading resulted in decreases in the primary particle size distribution and increases in tapped density. This enabled fine particle doses of up to 25 mg to be achieved with a portable dry powder inhaler from a size three capsule. The powders were physically and chemically stable, with no changes in physical form or degradants observed during processing or on storage in an open configuration at 40°C for 1 month. The potential benefits of the suspension-based spray drying process relative to solution-based spray drying in terms of stability, lung targeting, and safety/tolerability are discussed.

show abstract

Effect of Lipidic Excipients on the Particle Properties and Aerosol Performance of High Drug Load Spray Dried Particles for Inhalation

Cited by 7 publications

References 31 publications

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

Mechanistic Formulation Design of Spray-Dried Powders

Formulation of Dry Powders for Inhalation Comprising High Doses of a Poorly Soluble Hydrophobic Drug

Contact Info

Product

Resources

About