The dipolar potentials of bilayer membranes are investigated as physical features which can be selectively altered by membrane chemical composition changes or membrane intrinsic receptor‐stimulant complexing interactions. The results imply that selective dipolar potential modification can lead to analytically useful signals in the form of transmembrane ion permeability changes. The dipolar potential and membrane molecular packing/fluidity apparently operate interdependently in a synergic manner which can chemically amplify analytical ion current signals.